scholarly journals Effect of Salt-Bromide-Iodine Thermal Water Inhalation on Functional and Biochemical Lung Parameters

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Massimo Corradi ◽  
Giuseppina Folesani ◽  
Petra Gergelova ◽  
Matteo Goldoni ◽  
Silvana Pinelli ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Lung Diseases ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Toxic Heavy Metals ◽  
Flow Rates ◽  
Before And After ◽  
Breath Condensate ◽  
Biomarkers Of Effect

Background. Inhalation of thermal water has been used empirically in the treatment of chronic diseases of upper and lower respiratory tract. This study investigates biomarkers of effect in exhaled breath (nitric oxide (NO)) and in exhaled breath condensate (EBC) (hydrogen peroxide (H2O2), anions, toxic heavy metals of tobacco smoke) for patients with lung diseases inhaling salt-bromide-iodine thermal water. Methods. This study enrolled two groups of patients, twenty with alveolar pulmonary diseases—pneumoconiosis—twenty-two with bronchial diseases. Patients received 12 days inhalation treatment with thermal water in Terme of Monticelli (Parma), Italy. Results. No statistically significant differences were found for NO at different flow rates in both groups of patients before and after thermal water inhalation. Also in EBC no statistically significant differences were present for H2O2 concentrations, toxic heavy metals concentrations, and anion concentrations before and after treatment. Nitrates in EBC were found to be significantly higher in patients before inhalation than in controls as well as in patients after inhalation versus controls. Conclusions. This study contributes to better quantify functional and biochemical changes in airways before and after thermal water treatment.

scholarly journals Exhaled Breath Condensate: Pilot Study of the Method and Initial Experience in Healthy Subjects

2018 ◽  
Vol 61 (1) ◽  
pp. 8-16
Author(s):  
Eva Peterová ◽  
Jaroslav Chládek ◽  
Darina Kohoutová ◽  
Veronika Knoblochová ◽  
Paula Morávková ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Coefficient Of Variation ◽  
Healthy Subjects ◽  
Lung Diseases ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Initial Experience ◽  
Major Disadvantage ◽  
Breath Condensate

Analysis of Exhaled breath condensate (EBC) is a re-discovered approach to monitoring the course of the disease and reduce invasive methods of patient investigation. However, the major disadvantage and shortcoming of the EBC is lack of reliable and reproducible standardization of the method. Despite many articles published on EBC, until now there is no clear consensus on whether the analysis of EBC can provide a clue to diagnosis of the diseases. The purpose of this paper is to investigate our own method, to search for possible standardization and to obtain our own initial experience. Thirty healthy volunteers provided the EBC, in which we monitored the density, pH, protein, chloride and urea concentration. Our results show that EBC pH is influenced by smoking, and urea concentrations are affected by the gender of subjects. Age of subjects does not play a role. The smallest coefficient of variation between individual volunteers is for density determination. Current limitations of EBC measurements are the low concentration of many biomarkers. Standardization needs to be specific for each individual biomarker, with focusing on optimal condensate collection. EBC analysis has a potential become diagnostic test, not only for lung diseases.

scholarly journals Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yan Liang ◽  
Samantha M. Yeligar ◽  
Lou Ann S. Brown
Keyword(s):  
Lung Diseases ◽  
Exhaled Breath Condensate ◽  
Analytical Techniques ◽  
Exhaled Breath ◽  
Sample Collection ◽  
Low Concentrations ◽  
Reduced And Oxidized Glutathione ◽  
Promising Source ◽  
Breath Condensate ◽  
Arachidonic Acid Derivatives

Exhaled breath condensate (EBC) has been increasingly studied as a noninvasive research method for sampling the alveolar and airway space and is recognized as a promising source of biomarkers of lung diseases. Substances measured in EBC include oxidative stress and inflammatory mediators, such as arachidonic acid derivatives, reactive oxygen/nitrogen species, reduced and oxidized glutathione, and inflammatory cytokines. Although EBC has great potential as a source of biomarkers in many lung diseases, the low concentrations of compounds within the EBC present challenges in sample collection and analysis. Although EBC is viewed as a noninvasive method for sampling airway lining fluid (ALF), validation is necessary to confirm that EBC truly represents the ALF. Likewise, a dilution factor for the EBC is needed in order to compare across subjects and determine changes in the ALF. The aims of this paper are to address the characteristics of EBC; strategies to standardize EBC sample collection and review available analytical techniques for EBC analysis.

scholarly journals Effects of Inhalation of Thermal Water on Exhaled Breath Condensate in Chronic Obstructive Pulmonary Disease

Respiration ◽  
2010 ◽  
Vol 79 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Gabriella Guarnieri ◽  
Silvia Ferrazzoni ◽  
Maria Cristina Scarpa ◽  
Alberto Lalli ◽  
Piero Maestrelli
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Obstructive Pulmonary Disease ◽  
Breath Condensate

scholarly journals Metallic elements in exhaled breath condensate of patients with interstitial lung diseases

2009 ◽  
Vol 3 (4) ◽  
pp. 046003 ◽  
Author(s):  
Massimo Corradi ◽  
Olga Acampa ◽  
Matteo Goldoni ◽  
Elena Adami ◽  
Pietro Apostoli ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Exhaled Breath Condensate ◽  
Interstitial Lung Diseases ◽  
Exhaled Breath ◽  
Metallic Elements ◽  
Breath Condensate

scholarly journals Investigation of pH of the exhaled breath condensate in inflammatory lung diseases

2005 ◽  
pp. 75-79
Author(s):  
E. Kh. Anaev ◽  
S. N. Avdeev ◽  
A. G. Chuchalin
Keyword(s):  
Cystic Fibrosis ◽  
Healthy Volunteers ◽  
Lung Diseases ◽  
Ph Monitoring ◽  
Exhaled Breath Condensate ◽  
Stable Condition ◽  
Exhaled Breath ◽  
Lung Pathology ◽  
Evaluation And Monitoring ◽  
Breath Condensate

Investigation of inflammatory markers in the exhaled breath condensate (EBC) is a non-invasive method for evaluation and monitoring of bronchopulmonary inflammation. Endogenous oxidative processes in the airways can be evaluated by pH measurement in the EBC. We examined 153 healthy volunteers (of them, 51 smokers) and 615 patients with lung pathology (of them, 131 asthma (BA) patients, 205 COPD patients, 43 patients with bronchiectasis, 72 patients with idiopathic lung fibrosis (ILF), 142 pneumonia patients, and 42 cystic fibrosis patients). EBC was collected with ECoScreen equipment (Erich Jaeger, Germany) using a standardized method. The EBC pH was measured using the f32 PH-meter (Beckman, USA) with a glass microelectrode. The average ECB pH was 6.16 ± 0.52 in BA, 6.35 ± 0.56 in COPD, 6.13 ± 0.46 in bronchiectasis, 5.98 ± 0.30 in ILF, 5.96 ± 0.37 in pneumonia, and 6.35 ± 0.23 in cystic fibrosis. It was significantly lower than in the healthy volunteers (6.97 ± 0.31, р < 0.0001). In patients with exacerbation of BA and COPD ECB pH was considerably lower compared with those in stable condition. A reliable growth of pH was noted in pneumonia patients after treatment of the disease. There was a correlation between ECB pH and severity of fibrotic and inflammatory disorders of lung tissue according to HRCT (r = –0.62, p = 0.01), lung diffusing capacity (r = 0.51, p = 0.01), Tiffeneau index (r = 0.68, p = 0.004) in ILF. Therefore, the ECB pH is a distinct marker of the airway inflammatory severity in lung pathology. The ECB pH monitoring can assess the inflammatory activity and efficacy of anti-inflammatory therapy in lung diseases.

scholarly journals Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Contoli ◽  
Giulia Gnesini ◽  
Giacomo Forini ◽  
Brunilda Marku ◽  
Alessia Pauletti ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Oxidant Stress ◽  
Antioxidant Properties ◽  
Isotonic Saline ◽  
Reducing Agents ◽  
Exhaled Breath ◽  
Copd Patients ◽  
Breath Condensate

Background. Inhalation of thermal water with antioxidant properties is empirically used for COPD.Aims. To evaluate the effects of sulphurous thermal water (reducing agents) on airway oxidant stress and clinical outcomes in COPD.Methods. Forty moderate-to-severe COPD patients were randomly assigned to receive 12-day inhalation with sulphurous thermal water or isotonic saline. Patients were assessed for superoxide anion (O2-) production in the exhaled breath condensate and clinical outcomes at recruitment, the day after the conclusion of the 12-day inhalation treatment, and one month after the end of the inhalation treatment.Results. Inhalation of reducing agents resulted in a significant reduction ofO2-production in exhaled breath condensate of COPD patients at the end of the inhalatory treatment and at followup compared to baseline. A significant improvement in the COPD assessment test (CAT) questionnaire was shown one month after the end of the inhalatory treatment only in patients receiving sulphurous water.Conclusion. Thermal water inhalation produced anin vivoantioxidant effect and improvement in health status in COPD patients. Larger studies are required in order to evaluate whether inhalation of thermal water is able to modify relevant clinical outcomes of the disease (the study was registered at clinicaltrial.gov—identifier:NCT01664767).

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