scholarly journals Reducing Agents Decrease the Oxidative Burst and Improve Clinical Outcomes in COPD Patients: A Randomised Controlled Trial on the Effects of Sulphurous Thermal Water Inhalation

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Contoli ◽  
Giulia Gnesini ◽  
Giacomo Forini ◽  
Brunilda Marku ◽  
Alessia Pauletti ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Oxidant Stress ◽  
Antioxidant Properties ◽  
Isotonic Saline ◽  
Reducing Agents ◽  
Exhaled Breath ◽  
Copd Patients ◽  
Breath Condensate

Background. Inhalation of thermal water with antioxidant properties is empirically used for COPD.Aims. To evaluate the effects of sulphurous thermal water (reducing agents) on airway oxidant stress and clinical outcomes in COPD.Methods. Forty moderate-to-severe COPD patients were randomly assigned to receive 12-day inhalation with sulphurous thermal water or isotonic saline. Patients were assessed for superoxide anion (O2-) production in the exhaled breath condensate and clinical outcomes at recruitment, the day after the conclusion of the 12-day inhalation treatment, and one month after the end of the inhalation treatment.Results. Inhalation of reducing agents resulted in a significant reduction ofO2-production in exhaled breath condensate of COPD patients at the end of the inhalatory treatment and at followup compared to baseline. A significant improvement in the COPD assessment test (CAT) questionnaire was shown one month after the end of the inhalatory treatment only in patients receiving sulphurous water.Conclusion. Thermal water inhalation produced anin vivoantioxidant effect and improvement in health status in COPD patients. Larger studies are required in order to evaluate whether inhalation of thermal water is able to modify relevant clinical outcomes of the disease (the study was registered at clinicaltrial.gov—identifier:NCT01664767).

EXHALED BREATH CONDENSATE MARKERS OF OXIDANT STRESS IN PATIENTS WITH PNEUMOCONIOSES

CHEST Journal ◽  
2008 ◽  
Vol 134 (4) ◽  
pp. 6S
Author(s):  
Daniela Pelclova ◽  
Zdenka Fenclova ◽  
Monika Krmencikova ◽  
Tomas Navratil ◽  
Marek Kuzma ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Oxidant Stress ◽  
Exhaled Breath ◽  
Breath Condensate

scholarly journals Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients

2009 ◽  
Vol 10 (1) ◽  
Author(s):  
Rembert Koczulla ◽  
Silvano Dragonieri ◽  
Robert Schot ◽  
Robert Bals ◽  
Stefanie A Gauw ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Healthy Controls ◽  
Copd Patients ◽  
Breath Condensate

scholarly journals Effects of Inhalation of Thermal Water on Exhaled Breath Condensate in Chronic Obstructive Pulmonary Disease

Respiration ◽  
2010 ◽  
Vol 79 (3) ◽  
pp. 216-221 ◽  
Author(s):  
Gabriella Guarnieri ◽  
Silvia Ferrazzoni ◽  
Maria Cristina Scarpa ◽  
Alberto Lalli ◽  
Piero Maestrelli
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Obstructive Pulmonary Disease ◽  
Breath Condensate

The impact of acute smoke exposure on selected biomarkers in exhaled breath condensate in COPD patients and healthy smokers

2016 ◽  
Author(s):  
Marta Maskey-Warzechowska ◽  
Patrycja Nejman-Gryz ◽  
Katarzyna Osinka ◽  
Paulina Lis ◽  
Kamila Malesa ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Smoke Exposure ◽  
Exhaled Breath ◽  
Copd Patients ◽  
The Impact ◽  
Breath Condensate

INHALED CORTICOSTEROIDS PREVENT EXHALED BREATH CONDENSATE ACIDIFICATION IN MECHANICALLY VENTILATED COPD PATIENTS

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 209S
Author(s):  
Aliaksandr Y. Skrahin ◽  
Aliaksandr S. Smirnou ◽  
Anatoli D. Tahanovich ◽  
Alena M. Skrahina ◽  
Andrei P. Astrauko
Keyword(s):  
Inhaled Corticosteroids ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Mechanically Ventilated ◽  
Copd Patients ◽  
Breath Condensate

Inflammatory mediators in exhaled breath condensate of healthy donors and exacerbated COPD patients

Cytokine ◽  
2012 ◽  
Vol 58 (3) ◽  
pp. 361-367 ◽  
Author(s):  
Nancy L. Tateosian ◽  
María J. Costa ◽  
Diego Guerrieri ◽  
Analía Barro ◽  
Juan A. Mazzei ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Copd Patients ◽  
Healthy Donors ◽  
Breath Condensate

scholarly journals Iron concentration in exhaled breath condensate decreases in ever-smokers and COPD patients

2018 ◽  
Vol 12 (4) ◽  
pp. 046009
Author(s):  
Andrew J Ghio ◽  
Joleen M Soukup ◽  
John McGee ◽  
Michael C Madden ◽  
Charles R Esther
Keyword(s):  
Exhaled Breath Condensate ◽  
Iron Concentration ◽  
Exhaled Breath ◽  
Copd Patients ◽  
Breath Condensate

scholarly journals Effect of Salt-Bromide-Iodine Thermal Water Inhalation on Functional and Biochemical Lung Parameters

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Massimo Corradi ◽  
Giuseppina Folesani ◽  
Petra Gergelova ◽  
Matteo Goldoni ◽  
Silvana Pinelli ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Lung Diseases ◽  
Thermal Water ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Toxic Heavy Metals ◽  
Flow Rates ◽  
Before And After ◽  
Breath Condensate ◽  
Biomarkers Of Effect

Background. Inhalation of thermal water has been used empirically in the treatment of chronic diseases of upper and lower respiratory tract. This study investigates biomarkers of effect in exhaled breath (nitric oxide (NO)) and in exhaled breath condensate (EBC) (hydrogen peroxide (H2O2), anions, toxic heavy metals of tobacco smoke) for patients with lung diseases inhaling salt-bromide-iodine thermal water. Methods. This study enrolled two groups of patients, twenty with alveolar pulmonary diseases—pneumoconiosis—twenty-two with bronchial diseases. Patients received 12 days inhalation treatment with thermal water in Terme of Monticelli (Parma), Italy. Results. No statistically significant differences were found for NO at different flow rates in both groups of patients before and after thermal water inhalation. Also in EBC no statistically significant differences were present for H2O2 concentrations, toxic heavy metals concentrations, and anion concentrations before and after treatment. Nitrates in EBC were found to be significantly higher in patients before inhalation than in controls as well as in patients after inhalation versus controls. Conclusions. This study contributes to better quantify functional and biochemical changes in airways before and after thermal water treatment.

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