scholarly journals Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines and determination of TRAIL sensitivity

2013 ◽  
Vol 3 (6) ◽  
Author(s):  
Elenia Riddick ◽  
Shavonda Evans ◽  
Jeffrey Rousch ◽  
Ephraim Gwebu ◽  
Hirendra Nath Banerjee
Keyword(s):  
Cell Lines ◽  
Death Receptors ◽  
Astrocytoma Cell ◽  
Trail Sensitivity

Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

2020 ◽  
Vol 17 (3) ◽  
pp. 206-210
Author(s):  
Ty Viet Pham ◽  
Thang Quoc Le ◽  
Anh Tuan Le ◽  
Hung Quoc Vo ◽  
Duc Viet Ho
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Structural Determination ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
Phytochemical Constituents ◽  
First Time ◽  
Annona Reticulata

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

scholarly journals Apolipoprotein B mRNA editing. Direct determination of the edited base and occurrence in non-apolipoprotein B-producing cell lines.

1990 ◽  
Vol 265 (36) ◽  
pp. 22446-22452 ◽  
Author(s):  
K Boström ◽  
Z Garcia ◽  
K S Poksay ◽  
D F Johnson ◽  
A J Lusis ◽  
...  
Keyword(s):  
Cell Lines ◽  
Apolipoprotein B ◽  
Direct Determination ◽  
Mrna Editing

scholarly journals An Unprecedented High Content of the Bioactive Flavone Tricin in Huperzia Medicinal Species Used by the Saraguro in Ecuador

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100
Author(s):  
Chabaco Armijos ◽  
Jorge Ponce ◽  
Jorge Ramírez ◽  
Davide Gozzini ◽  
Paola Vita Finzi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Traditional Medicine ◽  
Cell Lines ◽  
Cancer Cell ◽  
Potent Inhibitor ◽  
Community Living ◽  
Medicinal Species ◽  
Chemopreventive Agent ◽  
Southern Ecuador

The flavone tricin (5,7,4′-trihydroxy-3′,5′-dimethoxyflavone) is considered to be a selective potent inhibitor of different cancer cell lines and a potential colorectal cancer chemopreventive agent. In this paper we describe a reliable UHPLC-UV-ESIMS method for the determination of tricin in Huperzia plants used in the traditional medicine of the Saraguro community living in Southern Ecuador. An unusually high amount of tricin was found in H. brevifolia and H. compacta, which exceeded the content of this flavone determined so far in other plants.

Toxoplasma gondii invasion and replication in astrocyte primary cultures and astrocytoma cell lines: systematic review of the literature

2012 ◽  
Vol 110 (6) ◽  
pp. 2089-2094 ◽  
Author(s):  
Carla O. Contreras-Ochoa ◽  
Alfredo Lagunas-Martínez ◽  
Jaime Belkind-Gerson ◽  
Dolores Correa
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Cell Lines ◽  
Primary Cultures ◽  
Review Of The Literature ◽  
Astrocytoma Cell

scholarly journals New rat astrocytoma cell lines induced in vitro by chemical adhesive of epoxy resin-polyamine composition.

1986 ◽  
Vol 62 (3) ◽  
pp. 109-112 ◽  
Author(s):  
Kyoko KANO-TANAKA ◽  
Taiji KATO ◽  
Jin-ichi ITO ◽  
Ryo TANAKA ◽  
Hiroko FUKAMI ◽  
...  
Keyword(s):  
Epoxy Resin ◽  
Cell Lines ◽  
Astrocytoma Cell

scholarly journals Synthesis of Lapachol-Based Glycosides and Glycosyl Triazoles with Antiproliferative Activity Against Several Cancer Cell Lines

2021 ◽  
Author(s):  
Flaviano Melo Ottoni ◽  
Lucas Bonfim Marques ◽  
Juliana Martins Ribeiro ◽  
Lucas Lopardi Franco ◽  
José Dias Souza Filho ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Adverse Effects ◽  
Dna Fragmentation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Biological Activities ◽  
Cancer Cell Lines ◽  
Tumor Cell Lines

Abstract Lapachol (1), a natural naphthoquinone, presents several biological activities including antitumor activity, used as anticancer coadjuvant whose use was abandoned because of adverse effects. Herein, we reported the synthesis and cytotoxicity evaluation against cancer cell lines of a series of Oglycosides and glycosyl triazoles derived from lapachol. In addition to the determination of IC50, the DNA fragmentation and clonogenicity were also evaluated. The glycoside derived from D-glucose (5) was far more active than lapachol (1) and more active in tumor cell lines HL60, Jurkat, THP-1 and MDA-MB-231 than to the non-tumoral PBMC cell line, indicating an improvement in activity and selectivity as compared with lapachol (1). Compound 5 and the glycosides derived from D-galactose (14), D-N-acetylglucosamine (15) and L-fucose (16) showed good results in the DNA fragmentation and clonogenicity assays in the studies of subdiploid DNA content, indicating a pro-apoptotic potential and a good antiproliferative activity of these glycosides.

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