scholarly journals Acute anti-inflammatory activity of ethanolic extract of leaves of Leucas indica by carrageenan induced paw oedema in wistar albino rats

2013 ◽  
Vol 2 (3) ◽  
pp. 302 ◽  
Author(s):  
Chandrashekar R ◽  
S Rao
Keyword(s):  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

scholarly journals Antibacterial, Antioxidant and Anti-Inflammatory Potential of the Different Extracts of Holoptelia Integrifolia

2019 ◽  
Vol 9 (2) ◽  
pp. 5234-5240
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Albino Rats ◽  
Nitric Oxide Radical ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Medicinal plants are play significant impact in the personal medicine for most of the people all over the world as an alternative live saving medicines and most of their medicinal properties are well known for anticancer activity. The different extracts of Holoptelea integrifolia (H.integrifolia) leaves, stem bark and fruits were studied as a potent natural source of antimicrobial, antioxidant and wound healing potential. This work was carried out to evaluate antimicrobial, antioxidant and anti-inflammatory activity of different extracts of H.integrifolia. The antimicrobial activity of the H.integrifolia ethanolic extract was studied against five fungal and bacterial strains by utilizing the agar well diffusion method and MIC. Among several strain, the ethanolic extract of fruit has shown higher antimicrobial inhibition zone as 9.25-16 mm compare to other two extracts of stem and leaves as 10- 13.25 mm and 6-10.2 mm respectively. The antioxidant activities for different extract were also determined by DPPH free radical assay, Hydroxyl Radical Scavenging and Nitric Oxide Radical Scavenging Activity method. The anti-inflammatory activity also estimated basedon formalin induced paw edema method on Wistar albino rats. The different extracts of leaves, stem bark and fruit parts of Holoptelea integrifolia were estimated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. The results of anti-inflammatory activity revealed that the Ethanol extracts showed vital and dose-dependent anti-inflammatory effects. Our findings revealed that aerial parts of H.integrifolia contais potential antimicrobial, antioxidant and anti-inflammatory compounds, which expose the medicinal potential of the selected plant could be a significant drug candidates against microbial, oxidative and inflammation-related pathological processes as a future alternative medicine.

scholarly journals Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

2019 ◽  
Vol 66 (2) ◽  
pp. 26-31
Author(s):  
H. Sunaryo ◽  
S. Siska ◽  
E. Hanani ◽  
RS. Anindita ◽  
N. Yanti ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Experimental Models ◽  
Albino Rats ◽  
Clinical Settings ◽  
Dependent Manner ◽  
Analgesic Effects ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Abstract Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.

scholarly journals Analgesic and Anti-Inflammatory Activity ofPinus roxburghiiSarg.

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Dhirender Kaushik ◽  
Ajay Kumar ◽  
Pawan Kaushik ◽  
A. C. Rana
Keyword(s):  
Diclofenac Sodium ◽  
Inflammatory Activity ◽  
Bark Extract ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Pinus Roxburghii ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Wistar Albino Rats ◽  
Chir Pine

The Chir Pine,Pinus roxburghii, named after William Roxburgh, is a pine native to the Himalaya.Pinus roxburghiiSarg. (Pinaceae) is traditionally used for several medicinal purposes in India. As the oil of the plant is extensively used in number of herbal preparation for curing inflammatory disorders, the present study was undertaken to assess analgesic and anti-inflammatory activities of its bark extract. Dried and crushed leaves ofPinus roxburghiiSarg. were defatted with petroleum ether and then extracted with alcohol. The alcoholic extract at the doses of 100 mg/kg, 300 mg/kg, and 500 mg/kg body weight was subjected to evaluation of analgesic and anti-inflammatory activities in experimental animal models. Analgesic activity was evaluated by acetic acid-induced writhing and tail immersion tests in Swiss albino mice; acute and chronic anti-inflammatory activity was evaluated by carrageenan-induced paw oedema and cotton pellet granuloma in Wistar albino rats. Diclofenac sodium and indomethacin were employed as reference drugs for analgesic and anti-inflammatory studies, respectively. In the present study, the alcoholic bark extract ofPinus roxburghiiSarg. demonstrated significant analgesic and anti-inflammatory activities in the tested models.

Antibacterial, Antioxidant and Anti-Inflammatory Potential of the Different Extracts of Holoptelia Integrifolia

2019 ◽  
Vol 9 (2) ◽  
pp. 5234-5240
Author(s):  
Dr.T.Mohammad Munawar ◽  
◽  
Dr.D.Muralidhara Rao ◽  
Dr. P. Subramanyam ◽  
◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Diffusion Method ◽  
Albino Rats ◽  
Nitric Oxide Radical ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Medicinal plants are play significant impact in the personal medicine for most of the people all over the world as an alternative live saving medicines and most of their medicinal properties are well known for anticancer activity. The different extracts of Holoptelea integrifolia (H.integrifolia) leaves, stem bark and fruits were studied as a potent natural source of antimicrobial, antioxidant and wound healing potential. This work was carried out to evaluate antimicrobial, antioxidant and anti-inflammatory activity of different extracts of H.integrifolia. The antimicrobial activity of the H.integrifolia ethanolic extract was studied against five fungal and bacterial strains by utilizing the agar well diffusion method and MIC. Among several strain, the ethanolic extract of fruit has shown higher antimicrobial inhibition zone as 9.25-16 mm compare to other two extracts of stem and leaves as 10- 13.25 mm and 6-10.2 mm respectively. The antioxidant activities for different extract were also determined by DPPH free radical assay, Hydroxyl Radical Scavenging and Nitric Oxide Radical Scavenging Activity method. The anti-inflammatory activity also estimated basedon formalin induced paw edema method on Wistar albino rats. The different extracts of leaves, stem bark and fruit parts of Holoptelea integrifolia were estimated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. The results of anti-inflammatory activity revealed that the Ethanol extracts showed vital and dose-dependent anti-inflammatory effects. Our findings revealed that aerial parts of H.integrifolia contais potential antimicrobial, antioxidant and anti-inflammatory compounds, which expose the medicinal potential of the selected plant could be a significant drug candidates against microbial, oxidative and inflammation-related pathological processes as a future alternative medicine.

scholarly journals Comparative anti-inflammatory activity of Clerodendrum serratum (Linn) Moon and Solanum xanthocarpum Schrad and Wendl in wistar ablino rats

2016 ◽  
Vol 5 (2) ◽  
pp. 38-44
Author(s):  
Poornima Solapure ◽  
◽  
Pradeep ◽  
Ravi Mundugaru ◽  
Prakash L Hegde ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Albino Rats ◽  
White Pulp ◽  
Tissue Formation ◽  
Paw Oedema ◽  
Anti Inflammatory ◽  
Folk Remedies ◽  
Wistar Albino Rats ◽  
Solanum Xanthocarpum ◽  
Granuloma Tissue

C. serratum and S. xanthocarpum plants are used as folk remedies for inflammations, arthritis, cough, asthma and bronchitis. The present investigation aimed to evaluate the comparative anti-inflammatory activity in Wistar albino rats. The group specific rats were treated for seven consecutive days and subjected to carrageenan induced paw oedema and cotton pellet implanted granuloma tissue formation tests at a dose of 8.64ml/kg (p.o). Both the test drugs have shown reduced paw volume during third and sixth hour readings and a moderate decrease in the granuloma tissue formation. CRP enzyme was found to be reduced significantly and a moderate elevation in white pulp of spleen from both the test groups were observed. The present findings suggest that both the drugs have moderate anti-inflammatory activity as ascertained by the comparative decrease in carrageenan induced paw volume, decreased granuloma tissue formation and normal histological profile of important organs.

scholarly journals Analgesic and anti-Inflammatory activity of Tradescantia fluminensis leaves extract

2017 ◽  
Vol 6 (1) ◽  
pp. 34-37
Author(s):  
Wilson Rwai Waweru ◽  
◽  
Lawrence Obado Osuwat ◽  
Connie Wambui Mureithi ◽  
◽  
...  
Keyword(s):  
Leaf Extract ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Control Group ◽  
Albino Rats ◽  
Crude Leaf Extract ◽  
Tradescantia Fluminensis ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
Wistar Albino Rats

Objective: The present study sought to evaluate the anti-inflammatory and analgesic activities of ethanolic extract from Tradescantia fluminensis leaves. Methods: The crude leaf extract of T. fluminensis was investigated for anti-inflammatory and analgesic activities in Wistar Albino rats and mice respectively. The anti-inflammatory activity was investigated using egg albumin induced oedema model while acetic acid and formalin-induced paw licking models were used to evaluate the analgesic activity. Results: The extract showed a significant (P<0.05) dose-dependent inhibition of inflammation and pain compared to the control group. Conclusion: The leaf extract possesses anti-inflammatory and analgesic activities. The activities could be attributed to phytochemicals present in the plant.

scholarly journals Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

2019 ◽  
Vol 10 (03) ◽  
pp. 259-271
Author(s):  
Loyce Nakalembe ◽  
Josephine N. Kasolo ◽  
Edward Nyatia ◽  
Aloysius Lubega ◽  
Godfrey S. Bbosa
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Phytolacca Dodecandra ◽  
Crude Leaf Extract ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Pharmacological Evaluation of Antipyretic, Analgesic and Anti-inflammatory Activities of Ethanolic Extract of Cassia fistula

2021 ◽  
Author(s):  
D.K. Sharma ◽  
S.K. Sharma ◽  
M.K. Lonare ◽  
Rajdeep Kaur ◽  
V.K. Dumka
Keyword(s):  
Analgesic Activity ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Bark Extract ◽  
Control Group ◽  
Albino Rats ◽  
Hot Plate ◽  
Antipyretic Activity ◽  
Tail Immersion ◽  
Anti Inflammatory

Background: The antipyretic, analgesic and anti-inflammatory activities of two concentrations (100 and 200 mg/kg) of ethanolic extract of leaf, bark, flower and fruit pulp of C. fistula were determined in male wistar albino rats. Methods: Antipyretic activity was assessed by E. coli endotoxin induced pyrexia. Analgesic activity was assessed by hot plate, tail immersion and acetic acid induced writhing test. Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema assay. Result: Significant (p less than 0.05) antipyretic activity was exhibited from 2h onwards by bark extract @ 200 mg/kg and from 3h onwards by bark extract @100 mg/kg and leaves extract @ 200mg/kg as compared to control group. Significant (p less than 0.05) analgesic activity was shown by extract of bark @ 200 mg/kg as it is evident by increase in reflex time in hot plate (90,120,180 min), tail immersion test (120,180 min) and inhibition of writhing (32.12%). Significant (p less than 0.05) anti-inflammatory activity was exhibited from 3h post administration by bark @ 200 and leaves @ 100 and 200 mg/kg.

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