A randomized comparative study between low-dose magnesium sulphate and standard dose regimen for management of eclampsia

ABSTRACT Introduction Since menopause was related to variety of genitourinary, vasomotor, psychological and musculoskeletal changes, conjugated equine estrogen (CEE) was introduced for all menopause-related symptoms in various doses. Materials and methods It is a comparative study in which 100 postmenopausal women were selected (natural or surgical menopause) with one or more menopausal symptoms. All patients were randomly divided in two groups. Group A received 0.3 mg CEE and group B received 0.625 mg CEE, and both groups were compared with each other in various aspects. Results Both the groups were comparable to each other with respect to mean age, residence, type of menopause, total duration of menopause. Both the groups show comparable improvement in vasomotor, genitourinary and psychological symptoms and p > 0.05 which is not significant. On evaluation of bone mineral density (BMD), the group B showed significant improvement than group A (p < 0.001). Effect on endometrium was not significant. Conclusion Because of the complications of estrogen ± progestin, it should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risk for individual women. How to cite this article Yadav P, Singh R, Kaur H, Gupta M, Kumar S. Comparative Study of Low Dose Conjugate Equine Estrogen 0.3 mg vs Standard Dose Conjugate Equine Estrogen 0.625 mg as Hormone Replacement Therapy. J South Asian Feder Menopause Soc 2013;1(2):45-49.

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A comparative study of low dose magnesium sulphate therapy with standard pritchard's regime in the management of eclampsia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20162894 ◽

2016 ◽

pp. 2939-2943

Author(s):

Swarnalatha Mohanapu ◽

Sajeethakumari Raveendran ◽

Yogashalini Murugaiah ◽

Maitrayee Sen

Keyword(s):

Comparative Study ◽

Magnesium Sulphate ◽

Low Dose

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Comparison and Efficacy of Low-Dose and Standard-Dose Tamsulosin and Alfuzosin in Medical Expulsive Therapy for Lower Ureteral Calculi: Prospective, Randomized, Comparative Study

Korean Journal of Urology ◽

10.4111/kju.2012.53.5.349 ◽

2012 ◽

Vol 53 (5) ◽

pp. 349 ◽

Cited By ~ 15

Author(s):

Woo Heon Cha ◽

Jae Duck Choi ◽

Ki Ho Kim ◽

Young Jin Seo ◽

Kyungseop Lee

Keyword(s):

Comparative Study ◽

Low Dose ◽

Standard Dose ◽

Ureteral Calculi ◽

Medical Expulsive Therapy

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Comparative efficacy between rituximab versus conventional therapy and different dosage of rituximab in idiopathic membranous nephropathy

10.22541/au.161589993.31384782/v1 ◽

2021 ◽

Author(s):

Miaomiao Chen ◽

Gaosi Xu ◽

Xuexin Chen

Keyword(s):

Serum Albumin ◽

Membranous Nephropathy ◽

Dose Regimen ◽

Conventional Therapy ◽

Low Dose ◽

Standard Dose ◽

Cochrane Collaboration ◽

Idiopathic Membranous Nephropathy ◽

Moderate Risk ◽

Significant Difference

Abstract Objective: This study was to evaluate the efficacy of rituximab (RTX) versus conventional agents and different RTX dose regimens in the treatment of idiopathic membranous nephropathy (IMN). Methods: After systematically searched associated studies up to 1st December 2020, we performed a fixed and random-effects meta-analysis using the Stata software and evaluated the quality of included studies by the risk of bias scale of the Cochrane collaboration tool. Results: RTX had a higher total remission (TR) (OR = 2.663, 95% CI 1.361 to 5.210, P = 0.004) than conventional therapy for patients at moderate risk for lose of kidney function (pre-study proteinuria < 8 g/d), however, for patients at severe risk (pre-study proteinuria > 8 g/d), there was no significant difference in TR (OR = 0.691, 95% CI 0.064 to 7.423, P = 0.761). In RTX dose studies, standard dose regimen had a better effect of reducing proteinuria than low-dose regimen (Low dose MD = -3.999, 95% CI -6.177 to -1.820; standard dose MD = -5.220, 95% CI -7.160 to -3.279, P < 0.0001). Significant improvement in serum albumin was seen in patients treated with standard dose than low dose regimen (Low dose MD = 0.601, 95% CI 0.052 to 1.150, P = 0.032; standard dose MD = 0.963, 95% CI 0.740 to 1.185, P < 0.0001). Conclusion: For patients with moderate risk IMN, RTX treatment has a higher TR than conventional therapy. Standard dose RTX is more effective than low dose in reducing proteinuria and recovering serum albumin levels.

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