Cross sectional study of 39 Cases of Tuberculous Meningitis in North Bihar

Author(s):  
Munish Kumar ◽  
Avinash Goswami ◽  
Jayant Singh ◽  
Manoj Rastogi ◽  
Kamlesh Tewary
2013 ◽  
Vol 10 (1) ◽  
pp. 16 ◽  
Author(s):  
Henry Luma ◽  
Benjamin Clet Tchaleu ◽  
Bertrand Hugo Ngahane ◽  
Elvis Temfack ◽  
Marie Doualla ◽  
...  

Author(s):  
Munish Kumar ◽  
Avinash Goswami ◽  
Jayant Singh ◽  
Manoj Rastogi ◽  
Kamlesh Tewary

Author(s):  
Livia Noviani ◽  
Ida Parwati ◽  
Ganiem AR ◽  
Turbawati DK

The early diagnosis of definite tuberculous meningitis (TBM) is very important in reducing its mortality. The current gold standard ofTBM relies on the isolation of M. tuberculosis from cerebrospinal fluid (CSF) either with direct staining or M. tuberculosis culture, but theseexamination have a low sensitivity due to the pausibasilary condition. Recently there is an assay using rapid Immunochromatography(ICT) cocktail antigen TB in CSF to diagnose TBM. This method can detect ESAT-6, CFP-10 and MPT-64 antigen as an important virulencefactor for the spreading of bacteria to extra pulmonary which is secreted by M. tuberculosis in CSF from TBM patient. The aim of thisstudy was to know the validity of rapid ICT cocktail antigen TB using CSF against MODS culture and acid-fast bacili as a gold standardto diagnose TBM by analyzing. This study iscarried out by a descriptive observational study using cross sectional study design. Thesubjects are patients who were diagnosed as suspected TBM based on Marais criteria and were obtained from the Department of NeurologyHospital Dr. Hasan Sadikin. The examination was done at the Clinical Microbiology Department of Clinical Pathology Dr. Hasan Sadikinhospital since January 2014 until May 2014. A total of 41 subjects which consisted of six (6) subjects with a definite diagnosis of TBM,26 with probable TBM and nine (9) with possible TBM were enrolled in this study. The result of this assay againts acid-fast bacili has the100% sensitivity, 64.1% specificity, 12.5% PPV, 100% NPV, LR(+) 2.78, LR(–)0 and 65.8% accuracy. The result of this assay againtsM. tuberculosis culture has the 83.3% sensitivity, 68.5% specificity, PPV 31.2%, NPV 96%, LR(+) 2.65, LR(–)0.24, accuracy 70.7% andprevalence ratio 7.8. Based on this study, it can be concluded that the validity of this assay againts acid-fast bacili has a high sensitivity,moderate specificity, low PPV, high NPV and moderate accuracy. The result of this assay againts M. tuberculosis culture has a moderatesensitivity and specificity, low PPV, high NPV and moderate accuracy.


2021 ◽  
Vol 15 (9) ◽  
pp. 2278-2279
Author(s):  
Said Ayaz ◽  
Syed Sajid Munir ◽  
Sami ullah ◽  
Maimoona Saeed

Aim: To determine the frequency of common CT scan findings in children with Tuberculous meningitis Setting: Department of Pediatrics, Khyber Teaching Hospital, Peshawar. Study design: descriptive cross-sectional study. Duration: 6 months (3/7/2015 to 3/1/2016) Methodology: In this study, 178 patients were selected. Non probability sampling technique was used for sample collection. Results: In this study, mean age was 9 years with SD ± 2.54. 55% patients were male and 45% patients were female. Common CT scan findings among 178 patients were analyzed. 40% patients had hydrocephalous, 72% patients had meningeal enhancement, 3% patients had infraction, 5% patients had tuberculoma. Conclusion: Most common CT scan findings of Tuberculosis meningitis in children were meningeal enhancement 72% followed by hydrocephalous 40%. Keywords: hyponatremia, tuberculous meningitis


Author(s):  
Jaime Soria ◽  
Alfredo Chiappe ◽  
Jorge Gallardo ◽  
Joseph R Zunt ◽  
Andres G Lescano

Abstract We conducted a retrospective cross-sectional study of adult hospitalized patients with confirmed tuberculous meningitis to determine the impact of the timing of treatment initiation upon mortality. Mortality of tuberculous meningitis was high and associated with delay in initiation of treatment, older age, HIV infection, and higher disease severity at admission.


2010 ◽  
Vol 20 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Evelyn R. Klein ◽  
Barbara J. Amster

Abstract A study by Yaruss and Quesal (2002), based on responses from 134 of 239 ASHA accredited graduate programs, indicated that approximately 25% of graduate programs in the United States allow students to earn their degree without having coursework in fluency disorders and 66% of programs allow students to graduate without clinical experience treating people who stutter (PWS). It is not surprising that many clinicians report discomfort in treating PWS. This cross-sectional study compares differences in beliefs about the cause of stuttering between freshman undergraduate students enrolled in an introductory course in communicative disorders and graduate students enrolled and in the final weeks of a graduate course in fluency disorders.


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