To reduce the spread of COVID-19 transmission, government agencies in the United States (US) have recommended COVID prevention guidelines, including wearing masks and social distancing. However, compliance with these guidelines have been inconsistent. This study examined whether individual differences in decision-making and motivational propensities predicted compliance with COVID-19 preventative behaviors in a representative sample of US adults (N=225). Participants completed an online study in September 2020 that included a risky choice decision-making task, temporal discounting task, and measures of appropriate mask wearing, social distancing, and perceived risk of engaging in public activities. Linear regression results indicated that greater risky decision-making behavior and temporal discounting were associated with less appropriate mask-wearing behavior and social distancing. Additionally, demographic factors, including political affiliation and income level, were also associated with differences in COVID-19 preventative behaviors. Path analysis results showed that risky decision-making behavior, temporal discounting, and risk perception collectively predicted 61% of the variance in appropriate mask-wearing behavior. Individual differences in general decision-making patterns are therefore highly predictive of who complies with COVID-19 prevention guidelines.