scholarly journals Peripheral tissue oxygenation during standard CPB and miniaturized CPB (direct oxymetric tissue perfusion monitoring study)

2013 ◽  
Vol 157 (1) ◽  
pp. 81-89
Author(s):  
Jiri Mandak ◽  
Vladimir Brzek ◽  
Vladimir Svitek ◽  
Martin Dergel ◽  
James Lago Chek ◽  
...  

2018 ◽  
Vol 46 (6) ◽  
pp. 601-607
Author(s):  
S. E. Perez-Protto ◽  
J. D. Reynolds ◽  
R. Nazemian ◽  
J. You ◽  
J. S. Hata ◽  
...  

Current donor management practices target macrohaemodynamic parameters, but it is unclear if this leads to improvements in microvascular perfusion and tissue oxygenation; the latter may have more impact on organ status. In a recent preclinical study we determined that brain death impaired tissue perfusion and oxygen utilisation in swine while pharmacologic correction of these deficits improved organ function and reduced markers of tissue injury. As a first step in translating the preclinical findings, we conducted a prospective observational study to determine if there was an association between peripheral tissue oxygenation (measured by near-infrared spectroscopy) in deceased by neurological criteria human donors and the number of organs transplanted. In 60 donors, the mean time-weighted average of tissue oxygenation was 87.5% (standard deviation, SD, 5.2%) and the average number of organs transplanted was 3.5 (SD 2); there was a positive linear relationship between these two parameters. A 5% rise in tissue oxygenation was associated with an increase of 0.47 organs transplanted (95% confidence intervals 0.16 to 0.78) after adjusting for age (P=0.004). No such correlations were observed for the macrohaemodynamic or macro-oxygenation parameters (including arterial blood oxygenation). The results of this clinical trial are consistent with our preclinical work and support the postulate that targeting the microvasculature to improve tissue perfusion and tissue oxygen delivery in human donors has the potential to increase the quantity of organs suitable for transplant.



PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. e4275 ◽  
Author(s):  
Yujung Kang ◽  
Myunghwan Choi ◽  
Jungsul Lee ◽  
Gou Young Koh ◽  
Kihwan Kwon ◽  
...  


2010 ◽  
Vol 145 (3) ◽  
pp. e99-e101 ◽  
Author(s):  
Yujung Kang ◽  
Jungsul Lee ◽  
Kihwan Kwon ◽  
Chulhee Choi


2021 ◽  
Vol 3 (2) ◽  
pp. 41
Author(s):  
Anggi Agustina ◽  
Mukhamad Musta'in ◽  
Maksum Maksum

Fracture is the broken continuity of the bone. Based on type and size of the bone, bone can break when it is not strong enough to withstand the pressure applied to the bone. The purpose of this research was to determine the management of the ineffectiveness of peripheral tissue perfusion in Mrs.S suffering from third-day post ORIF with the indication of femur 1/3 distal dextra fracture in Cempaka room, Ungaran Regional Hospital. Management results obtained swollen femur on the third-day post ORIF. It can cause complications due to the ineffectiveness of peripheral tissue perfusion in the patient. A suggestion for nurses in the hospital is to be able to carry out routine observations in post-operative ORIF patients that might experience changing condition. Key words:ROM Exercise, Ineffective Peripheral Tissue Perfusion, Post ORIF



2012 ◽  
Vol 130 (5) ◽  
pp. 757e-758e ◽  
Author(s):  
Jian-Wei Wei ◽  
Jiang-Dong Ni ◽  
Zhong-Gen Dong ◽  
Li-Hong Liu ◽  
Zhao-Biao Luo ◽  
...  


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