scholarly journals Peripheral Tissue Oxygenation During Standard and Miniaturized Cardiopulmonary Bypass (Direct Oxymetric Tissue Perfusion Monitoring Study)

Artery Bypass ◽  
10.5772/54300 ◽  
2013 ◽  
Author(s):  
Jiri Mandak
Keyword(s):  
Cardiopulmonary Bypass ◽  
Tissue Oxygenation ◽  
Tissue Perfusion ◽  
Peripheral Tissue ◽  
Monitoring Study

scholarly journals Peripheral tissue oxygenation during standard CPB and miniaturized CPB (direct oxymetric tissue perfusion monitoring study)

2013 ◽  
Vol 157 (1) ◽  
pp. 81-89
Author(s):  
Jiri Mandak ◽  
Vladimir Brzek ◽  
Vladimir Svitek ◽  
Martin Dergel ◽  
James Lago Chek ◽  
...  
Keyword(s):  
Tissue Oxygenation ◽  
Tissue Perfusion ◽  
Peripheral Tissue ◽  
Monitoring Study

Peripheral Tissue Oxygenation and the Number of Organs Transplanted per Donor

2018 ◽  
Vol 46 (6) ◽  
pp. 601-607
Author(s):  
S. E. Perez-Protto ◽  
J. D. Reynolds ◽  
R. Nazemian ◽  
J. You ◽  
J. S. Hata ◽  
...  
Keyword(s):  
Management Practices ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Tissue Injury ◽  
Weighted Average ◽  
Tissue Perfusion ◽  
Preclinical Study ◽  
Blood Oxygenation ◽  
Peripheral Tissue ◽  
Arterial Blood

Current donor management practices target macrohaemodynamic parameters, but it is unclear if this leads to improvements in microvascular perfusion and tissue oxygenation; the latter may have more impact on organ status. In a recent preclinical study we determined that brain death impaired tissue perfusion and oxygen utilisation in swine while pharmacologic correction of these deficits improved organ function and reduced markers of tissue injury. As a first step in translating the preclinical findings, we conducted a prospective observational study to determine if there was an association between peripheral tissue oxygenation (measured by near-infrared spectroscopy) in deceased by neurological criteria human donors and the number of organs transplanted. In 60 donors, the mean time-weighted average of tissue oxygenation was 87.5% (standard deviation, SD, 5.2%) and the average number of organs transplanted was 3.5 (SD 2); there was a positive linear relationship between these two parameters. A 5% rise in tissue oxygenation was associated with an increase of 0.47 organs transplanted (95% confidence intervals 0.16 to 0.78) after adjusting for age (P=0.004). No such correlations were observed for the macrohaemodynamic or macro-oxygenation parameters (including arterial blood oxygenation). The results of this clinical trial are consistent with our preclinical work and support the postulate that targeting the microvasculature to improve tissue perfusion and tissue oxygen delivery in human donors has the potential to increase the quantity of organs suitable for transplant.

scholarly journals NIRS Measurement of Peripheral Fractional Oxygen Extraction (FOE) after Cardiopulmonary Bypass

2002 ◽  
Vol 16 (3-4) ◽  
pp. 191-197 ◽  
Author(s):  
Charles William Yoxall ◽  
Kusum Menon ◽  
Andrew John Macnab ◽  
Roy Everett Gagnon ◽  
Jacques Gerard LeBlanc
Keyword(s):  
Cardiopulmonary Bypass ◽  
Near Infrared ◽  
Tissue Perfusion ◽  
Venous Occlusion ◽  
Repeated Measurements ◽  
Oxygen Extraction ◽  
Critically Ill Children ◽  
Large Teaching Hospital ◽  
Pulmonary Artery Catheters ◽  
Oxyhaemoglobin Saturation

Objectives:To compare peripheral fractional oxygen extraction (FOE), as measured by near infrared spectroscopy (NIRS), with conventional indicators of tissue perfusion in haemodynamically stable and unstable children after cardiopulmonary bypass.Design:Observational study.Setting:Paediatric Intensive Care Unit of a large teaching hospital.Patients:17 children immediately after cardiopulmonary bypass. Male : female = 9 : 8, median age 7 months (range, newborn to 16 years).Methods:On admission, children were classified as “stable” or “unstable” based on the haemodynamic support they needed. Peripheral venous oxyhaemoglobin saturation (SvO2) was measured non-invasively using NIRS with venous occlusion. FOE was calculated from SvO2and arterial saturation measured by pulse oximetry. Repeated measurements of peripheral SvO2were made for up to 8 hours. In 5 children who had pulmonary artery catheters, simultaneous mixed SvO2measurements were recorded.Results:Median FOE was 7.9% higher in the unstable group than in the stable group (p= 0.013). Peripheral SvO2and mixed SvO2were correlated (R2= 0.65,p< 0.0001).Conclusions:Peripheral FOE is higher in unstable children. Changes in peripheral SvO2are related to changes in mixed SvO2. These measurements may provide useful information about haemodynamic status in critically ill children. Further evaluation of the technique is warranted.

The effects of hyperoxaemia on tissue oxygenation in patients with a nadir haematocrit lower than 20% during cardiopulmonary bypass

Perfusion ◽  
2015 ◽  
Vol 31 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Utkan Sevuk ◽  
Rojhat Altindag ◽  
Erkan Baysal ◽  
Baris Yaylak ◽  
Mehmet Sahin Adiyaman ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Tissue Oxygenation

scholarly journals Quantitative Analysis of Peripheral Tissue Perfusion Using Spatiotemporal Molecular Dynamics

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. e4275 ◽  
Author(s):  
Yujung Kang ◽  
Myunghwan Choi ◽  
Jungsul Lee ◽  
Gou Young Koh ◽  
Kihwan Kwon ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Quantitative Analysis ◽  
Tissue Perfusion ◽  
Peripheral Tissue

Tissue Heat Content and Distribution during and after Cardiopulmonary Bypass at 31 [degree sign]C and 27 [degree sign]C 

1998 ◽  
Vol 88 (6) ◽  
pp. 1511-1518 ◽  
Author(s):  
Angela Rajek ◽  
Rainer Lenhardt ◽  
Daniel I. Sessler ◽  
Andrea Kurz ◽  
Gunther Laufer ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Temperature Gradient ◽  
Heat Content ◽  
Peripheral Tissue ◽  
Tissue Temperature ◽  
Peripheral Compartment ◽  
Peripheral Tissues ◽  
The Core ◽  
Total Body ◽  
Body Heat

Background Afterdrop following cardiopulmonary bypass results from redistribution of body heat to inadequately warmed peripheral tissues. However, the distribution of heat between the thermal compartments and the extent to which core-to-peripheral redistribution contributes to post-bypass hypothermia remains unknown. Methods Patients were cooled during cardiopulmonary bypass to nasopharyngeal temperatures near 31 degrees C (n=8) or 27 degrees C (n=8) and subsequently rewarmed by the bypass heat exchanger to approximately 37.5 degrees C. A nasopharyngeal probe evaluated core (trunk and head) temperature and heat content. Peripheral compartment (arm and leg) temperature and heat content were estimated using fourth-order regressions and integration over volume from 19 intramuscular needle thermocouples, 10 skin temperatures, and "deep" foot temperature. Results In the 31 degrees C group, the average peripheral tissue temperature decreased to 31.9+/-1.4 degrees C (means+/-SD) and subsequently increased to 34+/-1.4 degrees C at the end of bypass. The core-to-peripheral tissue temperature gradient was 3.5+/-1.8 degrees C at the end of rewarming, and the afterdrop was 1.5+/-0.4 degrees C. Total body heat content decreased 231+/-93 kcal. During pump rewarming, the peripheral heat content increased to 7+/-27 kcal below precooling values, whereas the core heat content increased to 94+/-33 kcal above precooling values. Body heat content at the end of rewarming was thus 87+/-42 kcal more than at the onset of cooling. In the 27 degrees C group, the average peripheral tissue temperature decreased to a minimum of 29.8 +/-1.7 degrees C and subsequently increased to 32.8+/-2.1 degrees C at the end of bypass. The core-to-peripheral tissue temperature gradient was 4.6+/-1.9 degrees C at the end of rewarming, and the afterdrop was 2.3+/-0.9 degrees C. Total body heat content decreased 419+/-49 kcal. During pump rewarming, core heat content increased to 66+/-23 kcal above precooling values, whereas peripheral heat content remained 70+/-42 kcal below precooling values. Body heat content at the end of rewarming was thus 4+/-52 kcal less than at the onset of cooling. Conclusions Peripheral tissues failed to fully rewarm by the end of bypass in the patients in the 27 degrees C group, and the afterdrop was 2.3+/-0.9 degrees C. Peripheral tissues rewarmed better in the patients in the 31 degrees C group, and the afterdrop was only 1.5+/-0.4 degrees C.

Application of novel dynamic optical imaging for evaluation of peripheral tissue perfusion

2010 ◽  
Vol 145 (3) ◽  
pp. e99-e101 ◽  
Author(s):  
Yujung Kang ◽  
Jungsul Lee ◽  
Kihwan Kwon ◽  
Chulhee Choi
Keyword(s):  
Optical Imaging ◽  
Tissue Perfusion ◽  
Peripheral Tissue
Sign in / Sign up

Export Citation Format

Share Document