Chemical Profile and Biological Activities of Essential oil of Aerial parts of Artemisia monosperma Del. Growing in Libya

Lippia sidoides Cham. is a plant that belongs to the family Verbenaceae and is commonly known as “alecrim-pimenta”. It was first found in northeastern Brazil, where it is extensively used in traditional medicine. Many studies have been made with the essential oil of L. sidoides, which has a high content of the isomeric compounds thymol and carvacrol. L. sidoides extracts, and particularly the essential oil extracted from its aerial parts, have shown many biological activities such as antifungal, antibacterial, and insecticidal. Given the great biological potentialities of L. sidoides and the amount of recent studies about this plant, the present study aimed to make a survey of its general attributes, cultivation methods, chemical characterization of its extracts and essential oil, as well as its different biological activities.

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Chemical Profile and Anticancer Activity of Polyscias guilfoylei Leaf Essential Oil

The Natural Products Journal ◽

10.2174/2210315509666190624103355 ◽

2020 ◽

Vol 10 (4) ◽

pp. 372-383

Author(s):

Rajani Kurup ◽

Ajikumaran Nair Sadasivan ◽

Uthayakumari Kalavathy ◽

Sabulal Baby

Keyword(s):

Flow Cytometry ◽

Essential Oil ◽

Anticancer Activity ◽

Biological Activities ◽

Chemical Profile ◽

Dna Ladder ◽

In Vivo Assays ◽

Leaf Oil ◽

Leaf Essential Oil

Background: Polyscias guilfoylei, commonly called ‘geranium aralia’, is an erect shrub with dark green leaves. P. guilfoylei has been introduced to tropical countries and is generally cultivated in gardens for ornamental purposes. There are no previous studies on the essential oil of P. guilfoylei and its biological activities. Objective: In this study, we report the chemical profile of P. guilfoylei leaf essential oil and its anticancer activity tested by various in vitro and in vivo assays. Methods: The chemical profile of P. guilfoylei leaf oil was elucidated by Gas Chromatographic analyses (GC-FID, GC-MS). Anticancer activity of P. guilfoylei leaf oil was tested by MTT, morphological observations, DNA ladder, comet, caspase, flow cytometry and in vivo assays. Results: Gas chromatographic profiling of P. guilfoylei leaf oil identified 50 constituents (β-selinene 49.59%, α-selinene 21.68%, (Z)-falcarinol 11.65%). In MTT assay, P. guilfoylei leaf oil at 50, 25, 10, 5 and 1 μg/ml showed 98.6 ± 1.2, 95.3 ± 0.78, 76.8 ± 1.59, 43.6 ± 0.99 and 39.8 ± 1.17% DLA cell death, respectively (CD50 5.96 μg/ml). In flow cytometry, the majority of P. guilfoylei leaf oil (25 μg/ml) treated DLA cells showed an accumulation/cell arrest in G2M phase (61.7 ± 2.6%). In P. guilfoylei leaf oil treated mice (40 days), 5 animals (83.3%, each) were protected in 25, 50 mg/kg groups. Conclusion: P. guilfoylei leaf oil, with minimal toxicity to normal cells, exhibited significant anticancer activity against lymphoma cells enhancing its potential as an anticancer agent.

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Chemical profile and biological activities of the aerial parts of Senecio acaulis (L.f.) Sch.Bip

Pharmacognosy Research ◽

10.4103/pr.pr_149_17 ◽

2018 ◽

Vol 10 (2) ◽

pp. 130

Author(s):

RehabM S. Ashour ◽

AbeerM El Sayed ◽

MohamedF Elyamany ◽

DinaR Abou-Hussein

Keyword(s):

Biological Activities ◽

Chemical Profile ◽

Aerial Parts

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Chemical Composition and Biological Activities of Essential Oil and Hydrosol Extract from Aerial Parts of Cynoglossum cheirifolium L. from Algeria

Journal of Essential Oil Bearing Plants ◽

10.1080/0972060x.2020.1729249 ◽

2020 ◽

Vol 23 (1) ◽

pp. 97-104 ◽

Cited By ~ 1

Author(s):

Nouria Merad Boussalah

Keyword(s):

Chemical Composition ◽

Essential Oil ◽

Biological Activities ◽

Aerial Parts

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A Novel Chemical Profile of a Selective In Vitro Cholinergic Essential Oil from Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), a Native Andean Species of Ecuador

Molecules ◽

10.3390/molecules26010045 ◽

2020 ◽

Vol 26 (1) ◽

pp. 45

Author(s):

Sandra Espinosa ◽

Nicole Bec ◽

Christian Larroque ◽

Jorge Ramírez ◽

Barbara Sgorbini ◽

...

Keyword(s):

Gas Chromatography ◽

Essential Oil ◽

Positive Control ◽

Gas Chromatography Mass Spectrometry ◽

Chemical Profile ◽

Flame Ionization ◽

Aerial Parts ◽

Germacrene D ◽

Enantioselective Gc

A novel chemical profile essential oil, distilled from the aerial parts of Clinopodium taxifolium (Kunth) Govaerts (Lamiaceae), was analysed by Gas Chromatography-Mass Spectrometry (GC-MS, qualitative analysis) and Gas Chromatography with Flame Ionization Detector (GC-FID, quantitative analysis), with both polar and non-polar stationary phase columns. The chemical composition mostly consisted of sesquiterpenes and sesquiterpenoids (>70%), the main ones being (E)-β-caryophyllene (17.8%), α-copaene (10.5%), β-bourbonene (9.9%), δ-cadinene (6.6%), cis-cadina-1(6),4-diene (6.4%) and germacrene D (4.9%), with the non-polar column. The essential oil was then submitted to enantioselective GC analysis, with a diethyl-tert-butyldimethylsilyl-β-cyclodextrin diluted in PS-086 chiral selector, resulting in the following enantiomeric excesses for the chiral components: (1R,5S)-(−)-α-thujene (67.8%), (1R,5R)-(+)-α-pinene (85.5%), (1S,5S)-(−)-β-pinene (90.0%), (1S,5S)-(−)-sabinene (12.3%), (S)-(−)-limonene (88.1%), (S)-(+)-linalool (32.7%), (R)-(−)-terpinen-4-ol (9.3%), (S)-(−)-α-terpineol (71.2%) and (S)-(−)-germacrene D (89.0%). The inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of C. taxifolium essential oil was then tested, resulting in selective activity against BChE with an IC50 value of 31.3 ± 3.0 μg/mL (positive control: donepezil, IC50 = 3.6 μg/mL).

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