scholarly journals Effect of Birhi Vaiety of Date Palm Fruits, (Phoenix dactylifera L.) at the Tamr Stage on Serum Glucose Levels in Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 8 (1) ◽  
pp. 110
Author(s):  
Mohammed O. Ibrahim ◽  
Mousa N. Ahmad ◽  
Hani J. Hamad ◽  
Wasfy J. Hamad
Keyword(s):  
Blood Glucose ◽  
Date Palm ◽  
Phoenix Dactylifera ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Favourable Effect ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Phoenix Dactylifera L ◽  
Palm Fruits

<p>This study was carried out to investigate the effect of a dietary preparation of Birhi tamr (<em>Phoenix dactylifera</em> L.) on serum glucose levels and body weight in normal, diabetic insulin-treated and diabetic insulin-untreated rats. Diabetes was partially induced by intraperitoneal injection of streptozotocin (32.25 mg/kg). Thirty six male Sprague-Dawley rats (239 ± 8.4 g) were divided into two normal, two diabetic insulin-treated and two diabetic insulin-untreated groups. Each group was fed a diet containing either 0% or 10% tamr for six weeks. Fasting serum glucose levels were determined by enzymatic-calorimetric method using a standard kit procedure.Feeding 10% tamr did not show significant differences (P &gt; 0.05) in serum glucose levels in any of the normal and insulin-treated diabetic rats. Insulin-untreated diabetic rats fed 0% tamr or 10% tamr exhibited significantly (P &lt; 0.05) higher serum glucose levels (496 ± 81.6, 315 ± 61.1 mg/dl respectively) compared to normal (147 ± 5.3, 156 ± 7.6 mg/dl respectively) and insulin-treated diabetic rats (227 ± 17.6, 268± 18.9 mg/dl respectively). Feeding 10% tamr to insulin-untreated rats induced significant (P &lt; 0.05) reduction in this variable. The findings of the present study may provide support for the favourable effect of date palm fruits as tamr, on blood glucose in streptozotocin-diabetic rats. This effect cannot be simply explained on the basis of the macro-nutrient composition of tamr. However, due to the apparent effects of tamr on blood glucose in normal and insulin-treated and insulin-untreated diabetic rats, the possible presence of insulin-like substance in tamr may not be excluded. The mechanism of action of the blood glucose-lowering effect of tamr awaits further investigation.</p>

scholarly journals Antecedent glycemic control reduces severe hypoglycemia-induced neuronal damage in diabetic rats

2013 ◽  
Vol 304 (12) ◽  
pp. E1331-E1337 ◽  
Author(s):  
Candace M. Reno ◽  
Tariq Tanoli ◽  
Adam Bree ◽  
Dorit Daphna-Iken ◽  
Chen Cui ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Brain Damage ◽  
Insulin Treatment ◽  
Neuronal Damage ◽  
Blood Glucose Control ◽  
Severe Hypoglycemia ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Sprague Dawley Rats

Brain damage due to severe hypoglycemia occurs in insulin-treated people with diabetes. This study tests the hypothesis that chronic insulin therapy that normalizes elevated blood glucose in diabetic rats would be neuroprotective against brain damage induced by an acute episode of severe hypoglycemia. Male Sprague-Dawley rats were split into three groups: 1) control, non-diabetic; 2) STZ-diabetic; and 3) insulin-treated STZ-diabetic. After 3 wk of chronic treatment, unrestrained awake rats underwent acute hyperinsulinemic severe hypoglycemic (10–15 mg/dl) clamps for 1 h. Rats were subsequently analyzed for brain damage and cognitive function. Severe hypoglycemia induced 15-fold more neuronal damage in STZ-diabetic rats compared with nondiabetic rats. Chronic insulin treatment of diabetic rats, which nearly normalized glucose levels, markedly reduced neuronal damage induced by severe hypoglycemia. Fortunately, no cognitive defects associated with the hypoglycemia-induced brain damage were observed in any group. In conclusion, antecedent blood glucose control represents a major modifiable therapeutic intervention that can afford diabetic subjects neuroprotection against severe hypoglycemia-induced brain damage.

DATE PALM AND DATE PALM INFLORESCENCES IN THE LATE URUK PERIOD (C. 3300 B.C.): BOTANY AND ARCHAIC SCRIPT

Iraq ◽  
2019 ◽  
Vol 81 ◽  
pp. 221-239
Author(s):  
Marcin Z. Paszke
Keyword(s):  
Date Palm ◽  
Root Zone ◽  
Phoenix Dactylifera ◽  
Scientific Data ◽  
Phenotypic Traits ◽  
Palm Tree ◽  
Archaeological Data ◽  
Phoenix Dactylifera L ◽  
Artificial Fertilization ◽  
Palm Fruits

The earliest evidence suggesting the human utilisation of wild date palm fruits in the Near East is dated to the sixth and fifth millennia B.C. Despite the lack of archaeological data, it is commonly believed that at the end of the Late Uruk period (c. 3300–3100 B.C.) the Sumerians established the first date palm plantations. Nevertheless, this belief has never been well-proven by any scientific data, which makes this issue open to debate. This article points to the images of the date palm known from the pictographic script from Uruk as an important source of botanical data—a concept which has never been discussed in the literature—and elaborates on the phenotypic traits of the Phoenix dactylifera L. discernible there. It aims to establish the level and condition of horticultural knowledge of the cultivators of the date palm tree in the late fourth millennium B.C.Many of the botanical traits found on the date palm pictographs are noteworthy, especially where the morphology of the crown, trunk, and root zone are concerned. Most importantly, the identification of pictographs representing date palm inflorescences prompts us to the conclusion that the Sumerians discovered the dioecious nature of the Phoenix dactylifera L., selecting the staminate inflorescences to pollinate female trees by at least c. 3300 B.C. The discovery of this method of artificial fertilization was a turning point in Mesopotamian agriculture since it enabled farmers to obtain a better crop while economizing on space and labour, constituting the beginning of the date palm plantations that are still such a feature of present-day Iraq.

scholarly journals Studies on the Antidiabetic Activities ofCordyceps militarisExtract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan Dong ◽  
Tianjiao Jing ◽  
Qingfan Meng ◽  
Chungang Liu ◽  
Shuang Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Water Extract ◽  
Diabetic Rats ◽  
Cordyceps Militaris ◽  
Sprague Dawley ◽  
Alcohol Extract ◽  
Glucose Levels ◽  
Liver And Kidney ◽  
Antioxidative Effects

Due to substantial morbidity and high complications, diabetes mellitus is considered as the third “killer” in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities ofCordyceps militarison diet-streptozotocin-induced type 2 diabetes mellitus in rats. Diabetic rats were orally administered with water extract or alcohol extract at 0.05 g/kg and 2 g/kg for 3 weeks, and then, the factors levels related to blood glucose, lipid, free radicals, and even nephropathy were determined. Pathological alterations on liver and kidney were examined. Data showed that, similar to metformin,Cordyceps militarisextracts displayed a significant reduction in blood glucose levels by promoting glucose metabolism and strongly suppressed total cholesterol and triglycerides concentration in serum.Cordyceps militarisextracts exhibit antioxidative effects indicated by normalized superoxide dismutase and glutathione peroxidase levels. The inhibitory effects on blood urea nitrogen, creatinine, uric acid, and protein revealed the protection ofCordyceps militarisextracts against diabetic nephropathy, which was confirmed by pathological morphology reversion. Collectively,Cordyceps militarisextract, a safe pharmaceutical agent, presents excellent antidiabetic and antinephropathic activities and thus has great potential as a new source for diabetes treatment.

scholarly journals Effect of the seedling age and Compost to the growth of Palm Date Lulu (Phoenix Dactylifera L.) Nursery and Investigation of Female Seedling on Soil of Sub-Optimal Land

2020 ◽  
Vol 9 (2) ◽  
pp. 199-207
Author(s):  
Siti Masreah Bernas ◽  
Maria Fitriana ◽  
Andi Wijaya ◽  
Siti Nurul Aidil Fitri
Keyword(s):  
Seedling Growth ◽  
Date Palm ◽  
Phoenix Dactylifera ◽  
Second Step ◽  
Dioecious Plant ◽  
Seedling Age ◽  
Phoenix Dactylifera L ◽  
Palm Fruits ◽  
Very High ◽  
Growth Ability

Bernas SM, Fitriana M, Wijaya A, Fitri SNA. 2020. Effect of the seedling age and compost to the growth of palm date lulu (Phoenix Dactylifera L.) nursery and investigation of female seedling. Jurnal Lahan Suboptimal : Journal of Suboptimal Lands 9(2): 199-207.Indonesia imported very high amount of date palm fruits about 9.99 million kg or US$ 13.18 M, because of that it is necessary to develop a research about date palm seedling nursery and investigation of female date, since this is a dioecious plant. The aim of this investigation was to find out characteristics of female date seedling and the effects of seedling age and compost on seedling growth. There were 2 steps in this research: the first was application of compost on seedling (without and plus compost treatments) and the age of seedling (15 and 30 days old) for transplanting into polybag, the growth ability of plant was monitored. The second step was transplanting seedling at 30 days old into pan for investigation female date, which 20 seedlings were planted in one pan and replicated 3 times.  Results showed that compost increased roots and leaves growth on seedling.  Transplanted at 30 days old seedling had the ability to grow about 95% compared to 15 days old was only 45%. It was found that female seedling was about 25% and the rest (75%) was male or sterile. It is needed further investigation on growing female seedling in the field and can it produce fruit.

NEUROPROTECTIVE POTENTIAL OF AZADIRACHTA INDICA LEAVES IN DIABETIC RATS

2017 ◽  
Vol 10 (4) ◽  
pp. 243
Author(s):  
Nidhi Srivastva ◽  
Naveen Kumar Gupta ◽  
Sanjeev Puri ◽  
Veena Puri
Keyword(s):  
Blood Glucose ◽  
Azadirachta Indica ◽  
Leaf Extract ◽  
Microscopic Analysis ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sprague Dawley Rats ◽  
Neuro Protection

Objective: Azadirachta indica is a treasure of multiple pharmacological properties and presently leaves of this plant have been explored to evaluate the neuroprotective potential in diabetic rats.Methods: Male Sprague-Dawley rats were injected with single intra peritoneal dose of streptozotocin (60mg/ Kg body weight (BW.) to develop animal model of diabetes. Post twenty one days of streptozotocin induction, animals were treated with aqueous Azadirachta indica Leaf Extract (ALE, 600mg/Kg BW.) for seven consecutive days. Followed this, all animals were evaluated for the levels of blood glucose, lipid peroxidation (LPO), C Reactive Proteins (CRP), pro oxidant biomarkers and histological changes.Results: Streptozotocin treated rats exhibited elevated levels of blood glucose, LPO, CRP and altered pro oxidant biomarkers in comparison to control rats. Additionally, histological alterations/damage was evidenced as fragmentation, vacuolization, inflammation etc. However, ALE treatment to these rats significantly decreased blood glucose levels, LPO, CRP levels and restored pro-oxidants status. Light microscopic and ultra microscopic analysis also indicated less damage, tissue architectural changes in comparison to untreated diabetic rats. Further decrease in hyperalgesia and inflammation levels; along with protective and restorative changes following ALE treatment suggested the neuroprotective potential of Azadirachta indica leaves in diabetic rats.Conclusion: The oral administration of ALE to streptozotocin induced diabetic animals resulted in neuro-protection against degenerative oxidative stress associated with metabolic and histopathological damage in the brain.Key words:  Azadirachta indica, Antioxidants, Hyperalgesia, Neuroprotection  

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