Left ventricular remodeling impacts coronary flow reserve in diabetic patients: what is the mechanism?

2015 ◽  
Vol 43 (1) ◽  
pp. 58-59 ◽  
Author(s):  
Bahar Pirat
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Flow Reserve

Left ventricular remodeling impairs coronary flow reserve in hypertensive patients

2002 ◽  
Vol 20 (7) ◽  
pp. 1431-1437 ◽  
Author(s):  
Stefan Schäfer ◽  
Malte Kelm ◽  
Stefan Mingers ◽  
Bodo E. Strauer
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Flow Reserve

scholarly journals THE EFFECT OF CORONARY FLOW RESERVE AFTER REPERFUSION OF ACUTE MYOCARDIAL INFARCTION ON LEFT VENTRICULAR REMODELING AND FUNCTION

2012 ◽  
Vol 59 (13) ◽  
pp. E366
Author(s):  
Yuichi Ninomiya ◽  
Masanori Tsurugida ◽  
Kazuhiro Anzaki ◽  
Koichi Kihara ◽  
Shuichi Hamasaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Flow Reserve ◽  
And Function

scholarly journals Coronary Flow Reserve in the Remote Myocardium Predicts Left Ventricular Remodeling Following Acute Myocardial Infarction

2014 ◽  
Vol 55 (4) ◽  
pp. 904 ◽  
Author(s):  
Rongchao Cheng ◽  
Guoqian Wei ◽  
Longhao Yu ◽  
Zhendong Su ◽  
Li Wei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Remote Myocardium ◽  
Flow Reserve

The relationship between early left ventricular myocardial alterations and reduced coronary flow reserve in non-insulin-dependent diabetic patients with microvascular angina

2012 ◽  
Vol 154 (3) ◽  
pp. 250-255 ◽  
Author(s):  
Antonello D'Andrea ◽  
Stefano Nistri ◽  
Francesca Castaldo ◽  
Maurizio Galderisi ◽  
Donato Mele ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Microvascular Angina ◽  
Flow Reserve ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
The Relationship

scholarly journals Insulin resistance is associated with similarly impaired LV myocardial deformation, untwisting and coronary flow reserve in first degree relatives and diabetic patients

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4286-P4286
Author(s):  
I. Ikonomidis ◽  
V. Lambadiari ◽  
G. Pavlidis ◽  
C. Koukoulis ◽  
F. Kousathana ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Myocardial Deformation ◽  
Diabetic Patients ◽  
First Degree Relatives ◽  
Flow Reserve

Impairment of coronary flow reserve in aortic stenosis

2009 ◽  
Vol 106 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Damien Garcia ◽  
Paolo G. Camici ◽  
Louis-Gilles Durand ◽  
Kim Rajappan ◽  
Emmanuel Gaillard ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Left Ventricular ◽  
Adverse Outcomes ◽  
Lumped Parameter Model ◽  
Effective Orifice Area ◽  
Sensitivity Index ◽  
Coronary Perfusion ◽  
Flow Reserve ◽  
Wide Range

Coronary flow reserve (CFR) is markedly reduced in patients with severe aortic valve stenosis (AS), but the exact mechanisms underlying this impairment of CFR in AS remain unclear. Reduced CFR is the key mechanism leading to myocardial ischemia symptoms and adverse outcomes in AS patients. The objective of this study was to develop an explicit mathematical model formulated with a limited number of parameters that describes the effect of AS on left coronary inflow patterns and CFR. We combined the mathematical V3 (ventricular-valvular-vascular) model with a new lumped-parameter model of coronary inflow. One thousand Monte-Carlo computational simulations with AS graded from mild up to very severe were performed within a wide range of physiological conditions. There was a good agreement between the CFR values computed with this new model and those measured in 24 patients with isolated AS ( r = 0.77, P < 10−4). A global sensitivity analysis showed that the valve effective orifice area (EOA) was the major physiological determinant of CFR (total sensitivity index = 0.87). CFR was markedly reduced when AS became severe, i.e., when EOA was <1.0 cm2, and was generally exhausted when the EOA was <0.5–0.6 cm2. The reduction of CFR that is associated with AS can be explained by the concomitance of 1) reduced myocardial supply as a result of decreased coronary perfusion pressure, and 2) increased myocardial metabolic demand as a result of increased left ventricular workload.

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