scholarly journals Safety Concern Following Sub-acute Exposure to the Popular Food Additives, Sorghum bicolor and Saltpetre, Either Separately or in Combination in Sprague-Dawley Rats

Pharmacologia ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 95-104
Author(s):  
Martins Ekor ◽  
Daniels Konja ◽  
Isaac Tabiri Hen ◽  
Samuel Badu-Nyark ◽  
Samuel Addo Akwet ◽  
...  
Keyword(s):  
Sorghum Bicolor ◽  
Safety Concern ◽  
Food Additives ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in Sprague Dawley rats

2018 ◽  
Vol 88 (3-4) ◽  
pp. 199-208
Author(s):  
Elham Nikbakht ◽  
Rosita Jamaluddin ◽  
S. Mohd Redzwan ◽  
Saman Khalesi
Keyword(s):  
Adverse Effect ◽  
Lactobacillus Casei ◽  
Health Effect ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Treatment ◽  
Significant Difference ◽  
Aflatoxin B

Abstract. Aflatoxin B1 (AFB1) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB1 in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB1 only (n = 9); AFB1 treated with LcS (n = 9); and control (no AFB1 exposure) (n = 6) groups. The blood AFB1 level of rats treated with LcS was slightly lower than the untreated AFB1 induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g–1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB1 induced rats. However, a trend for a significant difference was only observed in ALT of AFB1 induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats’ body weight decreased in all animals force-fed with AFB1 with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB1 in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings.

Immunosuppression in weanling and adult Sprague-Dawley rats induced by acute exposure to 3,3′,4,4′-tetrachloroazoxybenzene

Toxicology ◽  
1984 ◽  
Vol 32 (4) ◽  
pp. 287-296 ◽  
Author(s):  
Leon John Olson ◽  
M.T.Stephen Hsia ◽  
Bill L. Kreamer ◽  
Ronald D. Hinsdill
Keyword(s):  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

A histopathology and behavioural study on the Sub-Acute exposure of traditional Anti-Diarrheal medicine on sprague dawley rats

2018 ◽  
Vol 21 (3and4) ◽  
pp. 27
Author(s):  
MM. Nogga Mudaliyar ◽  
M Muhamad Firdaus ◽  
NAS. Nik Nur Dayana ◽  
AK. Sairah ◽  
A Noor Azimah ◽  
...  
Keyword(s):  
Acute Exposure ◽  
Sprague Dawley ◽  
Behavioural Study ◽  
Sprague Dawley Rats

Effect of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley rats

2019 ◽  
Vol 367 ◽  
pp. 82-90 ◽  
Author(s):  
Minxia Zhu ◽  
Mengkang Xu ◽  
Kexin Zhang ◽  
Juanni Li ◽  
Hua Ma ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Hypobaric Hypoxia ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

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