Microscale Technologies For Tooth Tissue Engineering And Regenerative Endodontics

10.5580/17ea ◽  
2011 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Endodontics ◽  
Tooth Tissue

scholarly journals Review on regenerative endodontics: Past concepts, current protocols and future strategies

2021 ◽  
Vol 6 (4) ◽  
pp. 205-211
Author(s):  
Pranjali Naresh Patil ◽  
M Robert Justin ◽  
Aditi Subhashchandra Sarda ◽  
Lalit Dattu Darade ◽  
Supriya Ramchandra Zanjad ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Review Paper ◽  
American Association ◽  
New Horizons ◽  
Regenerative Endodontics ◽  
Tooth Tissue ◽  
Future Concepts

Till last few decades, a necrosed tooth with immature apex was an indication for apexogenesis. With advances in dentistry such as improved irrigation protocols, better visibility to the operating site and increased skills of endodontists, regenerative endodontic procedures have come into the limelight. The alongside research in tissue engineering also have been beneficial for researchers and endodontists to open new horizons in regenerative endodontics. This review paper involves the triad of tissue engineering, concepts of regenerative endodontics applied in past, current protocols according to American Association of Endodontists and future concepts of tooth tissue regenerations which are being researched.

Bioengineered Teeth from Cultured Rat Tooth Bud Cells

2004 ◽  
Vol 83 (7) ◽  
pp. 523-528 ◽  
Author(s):  
M.T. Duailibi ◽  
S.E. Duailibi ◽  
C.S. Young ◽  
J.D. Bartlett ◽  
J.P. Vacanti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Engineering Applications ◽  
Adult Rat ◽  
Dental Tissues ◽  
Biodegradable Scaffolds ◽  
Bioengineered Tooth ◽  
Tooth Tissue

The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methods by comparing the utility of cultured rat tooth bud cells obtained from three- to seven-day post-natal (dpn) rats for tooth-tissue-engineering applications. Cell-seeded biodegradable scaffolds were grown in the omenta of adult rat hosts for 12 wks, then harvested. Analyses of 12-week implant tissues demonstrated that dissociated 4-dpn rat tooth bud cells seeded for 1 hr onto PGA or PLGA scaffolds generated bioengineered tooth tissues most reliably. We conclude that tooth-tissue-engineering methods can be used to generate both pig and rat tooth tissues. Furthermore, our ability to bioengineer tooth structures from cultured tooth bud cells suggests that dental epithelial and mesenchymal stem cells can be maintained in vitro for at least 6 days.

Tooth Tissue Engineering and Regeneration—a Translational Vision!

2004 ◽  
Vol 83 (7) ◽  
pp. 517-517 ◽  
Author(s):  
Anthony J. (Tony) Smith
Keyword(s):  
Tissue Engineering ◽  
Tooth Tissue

scholarly journals Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Ting Gong ◽  
Boon Chin Heng ◽  
Edward Chin Man Lo ◽  
Chengfei Zhang
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Animal Studies ◽  
Banking System ◽  
Engineering Technology ◽  
Potential Health ◽  
Regenerative Endodontics ◽  
Immunological Rejection ◽  
Canal Systems ◽  
Scaffold Materials

Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration.

Regenerative Endodontics and Tissue Engineering

2012 ◽  
Vol 56 (3) ◽  
pp. 677-689 ◽  
Author(s):  
Harold E. Goodis ◽  
Bassam Michael Kinaia ◽  
Atheel M. Kinaia ◽  
Sami M.A. Chogle
Keyword(s):  
Tissue Engineering ◽  
Regenerative Endodontics

Evaluation of scaffold materials for tooth tissue engineering

2010 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Takayuki Ohara ◽  
Toshimitsu Itaya ◽  
Kazutada Usami ◽  
Yusuke Ando ◽  
Hiroya Sakurai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Scaffold Materials ◽  
Tooth Tissue

scholarly journals Dental pulp tissue engineering

2011 ◽  
Vol 22 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Flávio Fernando Demarco ◽  
Marcus Cristian Muniz Conde ◽  
Bruno Neves Cavalcanti ◽  
Luciano Casagrande ◽  
Vivien Thiemy Sakai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Dental Pulp ◽  
Regeneration Capacity ◽  
Pulp Tissue ◽  
Regenerative Endodontics ◽  
Mesenchymal Tissue ◽  
Dental Pulp Tissue ◽  
Anatomical Arrangement ◽  
Exciting Time ◽  
The Ideal

Dental pulp is a highly specialized mesenchymal tissue that has a limited regeneration capacity due to anatomical arrangement and post-mitotic nature of odontoblastic cells. Entire pulp amputation followed by pulp space disinfection and filling with an artificial material cause loss of a significant amount of dentin leaving as life-lasting sequelae a non-vital and weakened tooth. However, regenerative endodontics is an emerging field of modern tissue engineering that has demonstrated promising results using stem cells associated with scaffolds and responsive molecules. Thereby, this article reviews the most recent endeavors to regenerate pulp tissue based on tissue engineering principles and provides insightful information to readers about the different aspects involved in tissue engineering. Here, we speculate that the search for the ideal combination of cells, scaffolds, and morphogenic factors for dental pulp tissue engineering may be extended over future years and result in significant advances in other areas of dental and craniofacial research. The findings collected in this literature review show that we are now at a stage in which engineering a complex tissue, such as the dental pulp, is no longer an unachievable goal and the next decade will certainly be an exciting time for dental and craniofacial research.

Biomaterials in Tooth Tissue Engineering

2019 ◽  
pp. 91-115
Author(s):  
C. Pushpalatha ◽  
Shruthi Nagaraja ◽  
S. V. Sowmya ◽  
C. Kamala
Keyword(s):  
Tissue Engineering ◽  
Tooth Tissue

scholarly journals Tooth Tissue Engineering: The Importance of Blood Products as a Supplement in Tissue Culture Medium for Human Pulp Dental Stem Cells

2015 ◽  
Vol 21 (21-22) ◽  
pp. 2639-2648 ◽  
Author(s):  
Ricardo Luiz Pisciolaro ◽  
Monica Talarico Duailibi ◽  
Neil Ferreira Novo ◽  
Yara Juliano ◽  
Debora Pallos ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tissue Culture ◽  
Culture Medium ◽  
Tissue Culture Medium ◽  
Blood Products ◽  
Dental Stem Cells ◽  
Tooth Tissue

Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering

Biomaterials ◽  
2006 ◽  
Vol 27 (17) ◽  
pp. 3238-3248 ◽  
Author(s):  
Y SUMITA ◽  
M HONDA ◽  
T OHARA ◽  
S TSUCHIYA ◽  
H SAGARA ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Collagen Sponge ◽  
Tooth Tissue
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