Effect Of Single Oral Dose Of Ranitidine HCl Administered A Night Before Surgery On The Intragastric pH And Volume In Adult Patients Undergoing Elective Surgery: A Triple Blind Placebo Controlled Clinical Trial

10.5580/2d1 ◽  
2007 ◽  
Vol 12 (1) ◽  
Keyword(s):  
Clinical Trial ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Elective Surgery ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Intragastric Ph

Reduction of post-operative pain after tonsillectomy by a local mucosal flap – a prospective, randomized, controlled clinical trial on 100 adult patients

2018 ◽  
Vol 138 (10) ◽  
pp. 913-920 ◽  
Author(s):  
Maximilian Linxweiler ◽  
Jan Philipp Kühn ◽  
Mathias Wagner ◽  
Basel Al Kadah ◽  
Bernhard Schick
Keyword(s):  
Clinical Trial ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Mucosal Flap ◽  
Randomized Controlled ◽  
Post Operative Pain

scholarly journals Evaluation of the Effects ofVaccinium arctostaphylosL. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Rasool Soltani ◽  
Mustafa Hakimi ◽  
Sedigheh Asgary ◽  
Syed Mustafa Ghanadian ◽  
Mahtab Keshvari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Serum Levels ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Fruit Extract ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hs Crp ◽  
And Oxidative Stress

Background.Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease.Vaccinium arctostaphylosL. is a plant with fruits rich in anthocyanins. The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients.Methods.In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal (V. arctostaphylosfruit extract) or placebo capsules twice daily for 4 weeks. Each medicinal capsule contained 45 ± 2 mg of anthocyanins. Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared.Results. V. arctostaphylosfruit extract significantly reduced total cholesterol (P<0.001), LDL-C (P=0.004), TG (P<0.001), and MDA (P=0.013) compared to placebo but did not have any significant effect on HDL-C (P=0.631) and hs-CRP (P=0.190).Conclusion.Fruit extract ofVaccinium arctostaphyloshas beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients. Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.

Melatonin a Promising Candidate for DNA Double-Stranded Breaks Reduction in Patients Undergoing Abdomen-Pelvis Computed Tomography Examinations

2020 ◽  
Vol 20 (7) ◽  
pp. 859-864
Author(s):  
Ali Eskandari ◽  
Aziz Mahmoudzadeh ◽  
Alireza Shirazi ◽  
Farid Esmaely ◽  
Carla Carnovale ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Promising Candidate ◽  
Blood Lymphocytes ◽  
Ct Examination

Background and Objective: Cancer incidence is 24% higher in children and young adults exposed to Computed Tomography (CT) scans than those unexposed. Non-repairing of ionizing radiation-induced DNA Double-Strand Breaks (DSBs) can initiate carcinogenesis. In the present study, we aimed to investigate the radioprotective potential of melatonin against DSBs in peripheral blood lymphocytes of patients undergoing abdomen-pelvis CT examinations. Methods: This double-blind, placebo-controlled clinical trial was conducted on thirty patients. These patients were divided into two groups; group one (control) patients who have undergone the CT examination received a single oral dose of placebo, while in group two, patients received a single oral dose of 100mg melatonin. In both the groups, blood samples were collected 5-10min before and 30 minutes after the CT examination. The lymphocytes from these samples were isolated and DSBs were analyzed using γH2AX immunofluorescence microscopy. Results: Compared to the control group, the use of melatonin 1h before the CT examination caused a significant reduction in γH2AX-foci, indicating a reduction in DSBs. In addition, no side effect was observed in patients following 100mg melatonin administration. Conclusion: For the first time, this study has shown that melatonin has protective effects against radiationinduced genotoxicity in peripheral blood lymphocytes of patients undergoing abdomen-pelvis CT examinations. Therefore, melatonin can be considered as a promising candidate for reducing DSBs in patients undergoing abdomen-pelvis CT examinations.

scholarly journals Evaluation of the Effects ofCornus masL. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Rasool Soltani ◽  
Abdollah Gorji ◽  
Sedigheh Asgary ◽  
Nizal Sarrafzadegan ◽  
Mansour Siavash
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Glycemic Control ◽  
Insulin Level ◽  
Adult Patients ◽  
Controlled Clinical Trial ◽  
Fruit Extract ◽  
Cornus Mas ◽  
Type 2 Diabetic

Background. The plantCornus masL. (cornelian cherry) is traditionally used as an antidiabetic supplement; however, there is no related clinical trial. In this study, we evaluated the effects of the fruit extract of this plant on biomarkers of glycemic control in adult patients with type 2 diabetes.Methods. Sixty patients with type 2 diabetes were randomly assigned to two groups to receive either the extract or placebo capsules (2 capsules twice daily) for 6 weeks. Each drug capsule contained 150 mg of anthocyanins. Fasting plasma levels of glucose, insulin,HgbA1C, and triglyceride as well as 2-hour postprandial glucose level (2Hpp) were measured before and after the intervention and finally the mean values were compared between groups.Results. After 6 weeks of intervention, significant increase in insulin level (1.13 ± 1.90 versus −0.643 ± 1.82,P<0.05) as well as decrease inHgbA1C(−0.24 ± 0.429 versus 0.023 ± 0.225,P<0.05) and TG (−23.66 ± 55.40 versus 2.83 ± 15.71,P<0.05) levels was observed in drug group compared to placebo.Conclusion. Daily consumption of the fruit extract ofCornus masL. improves glycemic control by increasing insulin level and reduces TG serum level in type 2 diabetic adult patients.

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