Induced Hypothermia Following Cardiac Arrest And Subsequent Neurological Outcomes: An Audit

10.5580/edb ◽  
2011 ◽  
Vol 13 (2) ◽  
Keyword(s):  
Cardiac Arrest ◽  
Induced Hypothermia ◽  
Neurological Outcomes

scholarly journals Hypothermic modulation of anoxic brain injury in adult survivors of cardiac arrest: a review of the literature and an algorithm for emergency physicians

CJEM ◽  
2005 ◽  
Vol 7 (01) ◽  
pp. 42-47 ◽  
Author(s):  
Robert S. Green ◽  
Daniel Howes
Keyword(s):  
Cardiac Arrest ◽  
Brain Injury ◽  
Treatment Algorithm ◽  
Adult Survivors ◽  
Induced Hypothermia ◽  
Emergency Physicians ◽  
Review Of The Literature ◽  
Anoxic Brain Injury ◽  
Neurological Outcomes ◽  
Canadian Association

ABSTRACT Anoxic brain injury is a common outcome after cardiac arrest. Despite substantial research into the pathophysiology and management of this injury, a beneficial treatment modality has not been previously identified. Recent studies show that induced hypothermia reduces mortality and improves neurological outcomes in patients resuscitated from ventricular fibrillation. This article reviews the literature on induced hypothermia for anoxic brain injury and summarizes a treatment algorithm proposed by the Canadian Association of Emergency Physicians Critical Care Committee for hypothermia induction in cardiac arrest survivors.

Mild therapeutic hypothermia improves neurological outcomes in a rat model of cardiac arrest

2021 ◽  
Author(s):  
Liangliang Zhang ◽  
Wei Liang ◽  
Yiling Li ◽  
Jie Yan ◽  
Jingwen Xue ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Rat Model ◽  
Mild Therapeutic Hypothermia ◽  
Neurological Outcomes

scholarly journals Impact of the cardiopulmonary resuscitation-related injuries on the prognosis after cardiac arrest

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Merino Argos ◽  
I Marco Clement ◽  
S.O Rosillo Rodriguez ◽  
L Martin Polo ◽  
E Arbas Redondo ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Cerebral Performance Category ◽  
University Hospital ◽  
Temperature Management ◽  
Performance Category ◽  
Neurological Outcomes ◽  
Cardiac Care Unit ◽  
Sternal Fractures

Abstract Background Cardiopulmonary resuscitation (CPR) manoeuvres involve vigorous compressions with the proper depth and rate in order to keep sufficient perfusion to organs, especially the brain. Accordingly, high incidences of CPR-related injuries (CPR-RI) have been observed in survivors after cardiac arrest (CA). Purpose To analyse whether CPR-related injuries have an impact on the survival and neurological outcomes of comatose survivors after CA. Methods Observational prospective database of consecutive patients (pts) admitted to the acute cardiac care unit of a tertiary university hospital after in-hospital and out-of-hospital CA (IHCA and OHCA) treated with targeted temperature management (TTM 32–34°) from August 2006 to December 2019. CPR-RI were diagnosed by reviewing medical records and analysing image studies during hospitalization. Results A total of 498 pts were included; mean age was 62.7±14.5 years and 393 (78.9%) were men. We found a total of 145 CPR-RI in 109 (21.9%) pts: 79 rib fractures, 20 sternal fractures, 5 hepatic, 5 gastrointestinal, 3 spleen, 1 kidney, 26 lung and 6 heart injuries. Demographic characteristics and cardiovascular risk factors did not differ between the non-CPR-RI group and CPR-RI group. Also, we did not find differences in CA features (Table 1). Survival at discharge was higher in the CPR-RI group [74 (67.8%) vs 188 (48.3%); p<0.001]. Moreover, Cerebral Performance Category (CPC) 1–2 within a 3-month follow-up was significantly higher in the CPR-RI group [(71 (65.1%) vs 168 (43.2%); p<0.001; Figure 1]. Finally, pts who recieved blood transfusions were proportionally higher in the CPR-RI group [34 (32.1%) vs 65 (16.7%)]; p=0.004). Conclusions In our cohort, the presence of CPR-RI was associated with higher survival at discharge and better neurological outcomes during follow-up. Figure 1 Funding Acknowledgement Type of funding source: None

scholarly journals Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest

2020 ◽  
Vol 10 (1) ◽  
pp. 71
Author(s):  
Sung Eun Lee ◽  
Hyuk Hoon Kim ◽  
Minjung Kathy Chae ◽  
Eun Jung Park ◽  
Sangchun Choi
Keyword(s):  
Cardiac Arrest ◽  
Critically Ill ◽  
Lean Body Mass ◽  
Body Mass ◽  
Multivariate Regression ◽  
Characteristic Curve ◽  
Cerebral Performance Category ◽  
High Body Mass Index ◽  
Neurological Outcomes ◽  
Hospital Cardiac Arrest

Background: Postcardiac arrest patients with a return of spontaneous circulation (ROSC) are critically ill, and high body mass index (BMI) is ascertained to be associated with good prognosis in patients with a critically ill condition. However, the exact mechanism has been unknown. To assess the effectiveness of skeletal muscles in reducing neuronal injury after the initial damage owing to cardiac arrest, we investigated the relationship between estimated lean body mass (LBM) and the prognosis of postcardiac arrest patients. Methods: This retrospective cohort study included adult patients with ROSC after out-of-hospital cardiac arrest from January 2015 to March 2020. The enrolled patients were allocated into good- and poor-outcome groups (cerebral performance category (CPC) scores 1–2 and 3–5, respectively). Estimated LBM was categorized into quartiles. Multivariate regression models were used to evaluate the association between LBM and a good CPC score. The area under the receiver operating characteristic curve (AUROC) was assessed. Results: In total, 155 patients were analyzed (CPC score 1–2 vs. 3–5, n = 70 vs. n = 85). Patients’ age, first monitored rhythm, no-flow time, presumed cause of arrest, BMI, and LBM were different (p < 0.05). Fourth-quartile LBM (≥48.98 kg) was associated with good neurological outcome of postcardiac arrest patients (odds ratio = 4.81, 95% confidence interval (CI), 1.10–25.55, p = 0.04). Initial high LBM was also a predictor of good neurological outcomes (AUROC of multivariate regression model including LBM: 0.918). Conclusions: Initial LBM above 48.98kg is a feasible prognostic factor for good neurological outcomes in postcardiac arrest patients.

Pre-existing medical comorbidity is not associated with neurological outcomes in patients undergoing targeted temperature management following cardiac arrest

2017 ◽  
Vol 32 (11) ◽  
pp. 1358-1363 ◽  
Author(s):  
Arash Nayeri ◽  
Nirmanmoh Bhatia ◽  
Benjamin Holmes ◽  
Nyal Borges ◽  
Michael N. Young ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Targeted Temperature Management ◽  
Temperature Management ◽  
Medical Comorbidity ◽  
Neurological Outcomes

scholarly journals Early coronary angiography and induced hypothermia are associated with survival and functional recovery after out-of-hospital cardiac arrest

Resuscitation ◽  
2014 ◽  
Vol 85 (5) ◽  
pp. 657-663 ◽  
Author(s):  
Clifton W. Callaway ◽  
Robert H. Schmicker ◽  
Siobhan P. Brown ◽  
J. Michael Albrich ◽  
Douglas L. Andrusiek ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Coronary Angiography ◽  
Functional Recovery ◽  
Induced Hypothermia ◽  
Hospital Cardiac Arrest

scholarly journals Mild induced hypothermia after out-of-hospital cardiac arrest: persisting doubts about patient safety

Critical Care ◽  
2007 ◽  
Vol 11 (4) ◽  
pp. 420 ◽  
Author(s):  
Bhavesh M Patel ◽  
Alyssa B Chapital ◽  
Mohamed Y Rady ◽  
Joel S Larson
Keyword(s):  
Cardiac Arrest ◽  
Patient Safety ◽  
Induced Hypothermia ◽  
Hospital Cardiac Arrest
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