Prevalence and prognostic value of monoclonal gammopathy in heart failure patients with preserved ejection fraction: A prospective study

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

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Faculty Opinions recommendation of Temporal relationship and prognostic significance of atrial fibrillation in heart failure patients with preserved ejection fraction: a community-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718056194.793483548 ◽

2013 ◽

Author(s):

Gad Cotter ◽

Olga Milo

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Ejection Fraction ◽

Temporal Relationship ◽

Prognostic Significance ◽

Preserved Ejection Fraction ◽

Community Based ◽

Heart Failure Patients

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Abdominal obesity, and not general obesity, is associated with a lower 123I MIBG heart-to-mediastinum ratio in heart failure patients with preserved ejection fraction

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-021-05280-9 ◽

2021 ◽

Author(s):

Akihiro Sunaga ◽

◽

Shungo Hikoso ◽

Takahisa Yamada ◽

Yoshio Yasumura ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Abdominal Obesity ◽

Preserved Ejection Fraction ◽

General Obesity ◽

Heart Failure Patients ◽

Heart To Mediastinum Ratio

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REAL WORLD ANALYSIS OF OUTCOMES OF REMOTE PULMONARY ARTERY HEMODYNAMIC MONITORING IN HEART FAILURE PATIENTS WITH REDUCED AND PRESERVED EJECTION FRACTION

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(21)02156-2 ◽

2021 ◽

Vol 77 (18) ◽

pp. 797

Author(s):

Mansi Oberoi ◽

Naveen Rajpurohit ◽

Marian Petrasko ◽

Tomasz Stys ◽

Adam Stys ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Pulmonary Artery ◽

Hemodynamic Monitoring ◽

Real World ◽

Preserved Ejection Fraction ◽

Heart Failure Patients

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Abstract 13497: Prognostic Value of the Combination of the Echocardiographic Derived Pulmonary Artery Wedge Pressure and Body Mass Index in Patients With Heart Failure With Preserved Ejection Fraction: Insights From PURSUIT-HFpEF Registry

Circulation ◽

10.1161/circ.142.suppl_3.13497 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Kumpei Ueda ◽

Shungo Hikoso ◽

Daisaku D Nakatani ◽

Shunsuke Tamaki ◽

Masamichi Yano ◽

...

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Ejection Fraction ◽

Prognostic Value ◽

Left Ventricular ◽

Preserved Ejection Fraction ◽

Pulmonary Artery Wedge Pressure ◽

Patients With Heart Failure ◽

Wedge Pressure

Background: An elevated pulmonary artery wedge pressure (PAWP), a surrogate of left ventricular filling pressure, is associated with poor outcomes in patients with heart failure (HF). In addition, obesity paradox is well recognized in HF patients and body mass index (BMI) also provides a prognostic information. However, there is little information available on the prognostic value of the combination of the echocardiographic derived PAWP and BMI in patients with HF with preserved ejection fraction (HFpEF). Methods and Results: Patients data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study, which is a prospective multicenter observational registry for acute decompensated heart failure (ADHF) patients with HFpEF. We analyzed 548 patients after exclusion of patients undergoing hemodialysis, patients with in-hospital death, missing follow-up data, or missing data to calculate PAWP or BMI. Body weight measurement and echocardiography were performed just before discharge. PAWP was calculated using the Nagueh formula [PAWP = 1.24* (E/e’) + 1.9] with e’ = [(e’ septal + e’ lateral ) /2]. During a mean follow up period of 1.5±0.8 years, 86 patients had all-cause death (ACD). Multivariate Cox analysis showed that both PAWP (p=0.020) and BMI (p=0.0001) were significantly associated with ACD, independently of age and previous history of HF hospitalization, after the adjustment with gender, left ventricular ejection fraction, NT-proBNP and estimated glomerular filtration rate. Kaplan-Meier curve analysis revealed that there was a significant difference in the risk of ACD when patients were stratified into 3 groups based on the median values of PAWP (17.3) and BMI (21.4). Conclusions: The combination of the echocardiographic derived PAWP and BMI might be useful for stratifying ADHF patients with HFpEF at risk for the total mortality.

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