Pentosidine, advanced glycation end product, in acute ischaemic stroke patients with and without atrial rhythm disturbances

Background Data on outcome of endovascular treatment in patients with acute ischaemic stroke due to large vessel occlusion suffering from intravenous thrombolysis-associated intracranial haemorrhage prior to mechanical thrombectomy remain scarce. Addressing this subject, we report our multicentre experience. Methods A retrospective analysis of consecutive acute ischaemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion despite the pre-interventional occurrence of intravenous thrombolysis-associated intracranial haemorrhage was performed at five tertiary care centres between January 2010–September 2020. Baseline demographics, aetiology of stroke and intracranial haemorrhage, angiographic outcome assessed by the Thrombolysis in Cerebral Infarction score and clinical outcome evaluated by the modified Rankin Scale at 90 days were recorded. Results In total, six patients were included in the study. Five individuals demonstrated cerebral intraparenchymal haemorrhage on pre-interventional imaging; in one patient additional subdural haematoma was observed and one patient suffered from isolated subarachnoid haemorrhage. All patients except one were treated by the ‘drip-and-ship’ paradigm. Successful reperfusion was achieved in 4/6 (67%) individuals. In 5/6 (83%) patients, the pre-interventional intracranial haemorrhage had aggravated in post-interventional computed tomography with space-occupying effect. Overall, five patients had died during the hospital stay. The clinical outcome of the survivor was modified Rankin Scale=4 at 90 days follow-up. Conclusion Mechanical thrombectomy in patients with intravenous thrombolysis-associated intracranial haemorrhage is technically feasible. The clinical outcome of this subgroup of stroke patients, however, appears to be devastating with high mortality and only carefully selected patients might benefit from endovascular treatment.

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Obesity in acute ischaemic stroke patients treated with intravenous thrombolysis therapy

Neurological Research ◽

10.1080/01616412.2021.1939486 ◽

2021 ◽

pp. 1-8

Author(s):

Hongmin Li ◽

Suliman Khan ◽

Rabeea Siddique ◽

Qian Bai ◽

Yang Liu ◽

...

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Intravenous Thrombolysis ◽

Stroke Patients ◽

Thrombolysis Therapy

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Outcome estimation based on multimodal computed tomography examination in acute ischaemic stroke patients treated with mechanical thrombectomy

Videosurgery and Other Miniinvasive Techniques ◽

10.5114/wiitm.2019.84761 ◽

2019 ◽

Vol 14 (4) ◽

pp. 560-566

Author(s):

Bartłomiej Łasocha ◽

Paweł Brzegowy ◽

Agnieszka Słowik ◽

Paweł Latacz ◽

Roman Pułyk ◽

...

Keyword(s):

Computed Tomography ◽

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Mechanical Thrombectomy ◽

Stroke Patients

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High On-Treatment Platelet Reactivity in Danish Hyper-Acute Ischaemic Stroke Patients

Frontiers in Neurology ◽

10.3389/fneur.2018.00712 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 3

Author(s):

Charlotte L. Rath ◽

Niklas Rye Jørgensen ◽

Troels Wienecke

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Platelet Reactivity ◽

Stroke Patients

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Plasma D-Dimer Level in Different Types of Acute Ischaemic Stroke Patients: Experience at a Tertiary Hospital in Dhaka City

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v5i1.42162 ◽

2019 ◽

Vol 5 (1) ◽

pp. 13-17

Author(s):

Paritosh Kumar Sarkar ◽

Anwar Israil ◽

Mohammad Sayeed Hassan ◽

Abu Nayeem ◽

Md Azharul Hoque ◽

...

Keyword(s):

Internal Medicine ◽

Ischemic Stroke ◽

Ischaemic Stroke ◽

Clinical Diagnosis ◽

Acute Ischaemic Stroke ◽

Stroke Patients ◽

College Hospital ◽

Medical College ◽

Different Types ◽

D Dimer

Background: Plasma D-Dimer is a biomarker of thrombo-embolism. Objective: The purpose of the present study was to see the plasma D-dimer level in different types of acute ischaemic stroke patients. Methodology: This cross-sectional study was conducted in the Department of Neurology & Department of Internal Medicine at Dhaka Medical College Hospital, Dhaka, Bangladesh from July 2010 to June 2012 for a period of two (02) years. Patients with ischemic stroke with history within 7 days attending in the stroke clinic of Department of Neurology or admitted in the Department of Neurology and Internal Medicine through the outpatient and emergency Department of Dhaka Medical College Hospital (DMCH) were selected as study population for this study. Analysis of plasma D-Dimer was done in the Department of Hematology of DMCH.b Result: A total of 50 cases were recruited for this study. There were 24.0% lacunar infarcts, 40.0% atherothrombotic and 36.0% embolic infarcts in the study group. Highest level of plasma D-Dimer was observed in embolic (1700±964 ηg/ml) followed by atherothrombotic group (536±234 ηg/ml). The plasma D-Dimer was lowest (100±0 ηg/ml) in lacunar group. Concentration of Plasma D-Dimer showed significant correlation with clinical diagnosis in different subtypes of ischemic stroke (r=0.902; p=0.001) and also with risk factors, example, diabetes (r=0.319; p=0.012) and valvular heart disease (r=0.281; p=0.024), but no significant correlation with age, hypertension, hyperlipidaemia and smoking. Conclusion: In conclusion plasma D-Dimer is an important bio-marker in the clinical diagnosis and subtypes of ischemic stroke patients. Journal of National Institute of Neurosciences Bangladesh, 2019;5(1): 13-17

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Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis

European Journal of Neurology ◽

10.1111/ene.14447 ◽

2020 ◽

Vol 27 (12) ◽

pp. 2453-2462

Author(s):

A. H. Katsanos ◽

A. V. Alexandrov ◽

P. Mandava ◽

M. Köhrmann ◽

L. Soinne ◽

...

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Pulse Pressure ◽

Intravenous Thrombolysis ◽

Stroke Patients

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Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study

Scientific Reports ◽

10.1038/s41598-019-56487-8 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Kristian Lundsgaard Kraglund ◽

Janne Kaergaard Mortensen ◽

Søren Paaske Johnsen ◽

Grethe Andersen ◽

Erik Lerkevang Grove

Keyword(s):

Platelet Aggregation ◽

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Platelet Reactivity ◽

Significant Inhibition ◽

Controlled Study ◽

Double Blind Study ◽

Stroke Patients ◽

Double Blind ◽

Ssri Treatment

AbstractWe evaluated the effect of SSRI treatment on platelet aggregation in patients with ischaemic stroke and included patients from the randomized double-blind controlled study of citalopram in acute ischaemic stroke (TALOS). Patients on clopidogrel were included 6 months after acute ischaemic stroke. Platelet parameters, including P2Y12 platelet reactivity using the VerifyNow System, were measured at the last day of study treatment and repeated after a 14-day wash-out period. A total of 60 patients were included (n = 32 randomized to citalopram). Platelet aggregation levels did not differ between the citalopram group (mean 116, 95% CI 89 to 143) and the placebo group (mean 136, 95% CI 109 to 163) (On-treatment, p = 0.14). Similarly, there was no significant change in platelet aggregation in the citalopram group from on-treatment to post-treatment (mean difference 2.0; 95% CI −18 to 14). Platelet count, size and turnover were not affected by SSRI treatment. In conclusion, SSRI therapy did not lead to statistically significant inhibition of platelet aggregation in ischaemic stroke patients treated with clopidogrel.

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