scholarly journals Dabigatran Use Associated with Hemopericardium and Hemothorax

2020 ◽  
Vol 44 (3) ◽  
pp. 155-158
Author(s):  
Josip Katić ◽  
Jure Mirat ◽  
Dario Rahelić ◽  
Ružica Avelini Perković ◽  
Karla Katić ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Ultrasound Finding ◽  
Computed Tomography Scan ◽  
Nonvalvular Atrial Fibrillation ◽  
Oral Direct Thrombin Inhibitor ◽  
Left Pleural Effusion ◽  
Tomography Scan ◽  
Dabigatran Therapy

Concurrent spontaneous hemopericardium and hemothorax due to anticoagulant use are extremely rare in clinical practice. Dabigatran is an oral direct thrombin inhibitor approved to prevent stroke or thromboembolic episodes in patients with nonvalvular atrial fibrillation. We report the case of a 73-year-old man who received dabigatran therapy (150 mg twice a day) for 3 months and developed massive spontaneous hemothorax and hemopericardium associated with fever. Emergency chest computed tomography scan established higher-density pericardial effusion (22HU) and left pleural effusion of heterogeneous density (5–15 HU) which could be hemorrhagic content while the heart ultrasound finding confirmed pericardial effusion 7–9 mm thick, without affecting hemodynamics. Almost 1100 mL of blood was drained by ultrasoundguided thoracentesis. After excluding other possible causes, diagnostic withdrawal was performed for dabigatran and no further pleural or pericardium effusion developed after dabigatran was discontinued. Therefore, practitioners could be aware of hemothorax as well as hemopericardium as a potential complication of dabigatran therapy.

Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects

2003 ◽  
Vol 59 (7) ◽  
pp. 537-543 ◽  
Author(s):  
Michael Wolzt ◽  
Maria Wollbratt ◽  
Mia Svensson ◽  
Karin W�hlander ◽  
Margaretha Grind ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Healthy Subjects ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Nonvalvular Atrial Fibrillation ◽  
Oral Direct Thrombin Inhibitor

Oral Direct Thrombin Inhibitor Ximelagatran Compared with Warfarin for the Prevention of Venous Thromboembolism After Total Knee Arthroplasty

2006 ◽  
Vol 88 (5) ◽  
pp. 1163
Author(s):  
Paul A. Lotke ◽  
John J. Callaghan ◽  
Lawrence D. Dorr ◽  
Gerard H. Engh ◽  
Arlen D. Hanssen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Venous Thromboembolism ◽  
Knee Arthroplasty ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Oral Direct Thrombin Inhibitor ◽  
Total Knee

scholarly journals Voluminous Intrapericardial Lipoma Mimicking Pericardial Effusion

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Fabíola Prado de Morais ◽  
Noah Romero Nakajima ◽  
Olívia Félix Marconi Andalécio ◽  
Pedro de Santana Prudente ◽  
Guilherme Emílio Ferreira ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pericardial Effusion ◽  
Signs And Symptoms ◽  
Tumor Location ◽  
Pathological Examination ◽  
Computed Tomography Scan ◽  
Radiologic Imaging ◽  
Heart Tumors ◽  
Tomography Scan

Lipomas are rare primary heart tumors and may involve the endocardium, myocardium, or pericardium. Signs and symptoms depend on the tumor location and size. The intrapericardial lipoma we report has massive dimensions and mimics a pericardial effusion. A 38-year-old male complained of dyspnea and precordial pain. On physical examination, heart sounds were diminished. The patient had received extensive medication for a clinically suspected pericardial effusion due to heart failure. A voluminous mass resembling fat within the pericardial sac was revealed by transesophageal echocardiography and a computed tomography scan. The tumor was removed successfully by a subxiphoid surgical approach. The diagnosis of a 635 gram intrapericardial lipoma was confirmed by pathological examination. After surgery, the patient recovered well and was completely asymptomatic at a follow-up at 90 days. No medications were being taken since. The diagnosis of a pericardial effusion should be secured by imaging exams to avoid unnecessary medications. Cardiac lipomas can be readily recognized by their typical features on radiologic imaging. The surgical pathology examination confirms the diagnosis and rules out malignancy criteria.

Oral Direct Thrombin Inhibitor as an Alternative in the Management of Cerebral Venous Thrombosis: A Series of 15 Patients

2015 ◽  
Vol 10 (7) ◽  
pp. 1115-1118 ◽  
Author(s):  
Marcelo D. Mendonça ◽  
Raquel Barbosa ◽  
Vera Cruz-e-Silva ◽  
Sofia Calado ◽  
Miguel Viana-Baptista
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Oral Direct Thrombin Inhibitor

Single-center Experience with Gastrointestinal Bleeding in Patients Taking the New Oral Direct Thrombin Inhibitor Dabigatran

2013 ◽  
Vol 108 ◽  
pp. S492
Author(s):  
Martin Kaszubowski ◽  
Stephen Harrison ◽  
John Cunningham ◽  
James Francis ◽  
Michael Krier
Keyword(s):  
Gastrointestinal Bleeding ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Single Center ◽  
Oral Direct Thrombin Inhibitor ◽  
Single Center Experience

scholarly journals Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease

2011 ◽  
Vol 63 (5) ◽  
pp. 1416-1425 ◽  
Author(s):  
Galina S. Bogatkevich ◽  
Anna Ludwicka-Bradley ◽  
Paul J. Nietert ◽  
Tanjina Akter ◽  
Joanne van Ryn ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Murine Model ◽  
Dabigatran Etexilate ◽  
Direct Thrombin Inhibitor ◽  
Thrombin Inhibitor ◽  
Oral Direct Thrombin Inhibitor
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