scholarly journals Behavioral Tests for Evaluation of Information Processing and Cognitive Deficits in Rodent Animal Models of Neuropsychiatric Disorders

10.5772/37844 ◽  
2012 ◽  
Author(s):  
Ales Stuchlik ◽  
Tomas Petrasek ◽  
Hana Hatalov ◽  
Lukas Rambousek ◽  
Tereza Nekovarova ◽  
...  
Keyword(s):  
Information Processing ◽  
Animal Models ◽  
Cognitive Deficits ◽  
Neuropsychiatric Disorders ◽  
Behavioral Tests

scholarly journals New Horizons for Phenotyping Behavior in Rodents: The Example of Depressive-Like Behavior

2022 ◽  
Vol 15 ◽  
Author(s):  
Hugo Leite-Almeida ◽  
Magda J. Castelhano-Carlos ◽  
Nuno Sousa
Keyword(s):  
Animal Models ◽  
Treatment Strategies ◽  
Neuropsychiatric Disorders ◽  
Behavioral Neuroscience ◽  
Behavioral Tests ◽  
New Horizons ◽  
Study Behavior ◽  
Behavioral Parameters ◽  
Psychiatric Conditions ◽  
Neuroscience Community

The evolution of the field of behavioral neuroscience is significantly dependent on innovative disruption triggered by our ability to model and phenotype animal models of neuropsychiatric disorders. The ability to adequately elicit and measure behavioral parameters are the fundaments on which the behavioral neuroscience community establishes the pathophysiological mechanisms of neuropsychiatric disorders as well as contributes to the development of treatment strategies for those conditions. Herein, we review how mood disorders, in particular depression, are currently modeled in rodents, focusing on the limitations of these models and particularly on the analyses of the data obtained with different behavioral tests. Finally, we propose the use of new paradigms to study behavior using multidimensional strategies that better encompasses the complexity of psychiatric conditions, namely depression; these paradigms provide holistic phenotyping that is applicable to other conditions, thus promoting the emergence of novel findings that will leverage this field.

scholarly journals Aspects of animal models for major neuropsychiatric disorders

2014 ◽  
Vol 66 (3) ◽  
pp. 1105-1115 ◽  
Author(s):  
Radu Lefter ◽  
Dumitru Cojocaru ◽  
Alin Ciobica ◽  
Manuel Paulet ◽  
Lacramioara Serban ◽  
...  
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Biochemical Parameters ◽  
Neuropsychiatric Disorders ◽  
Behavioral Tests ◽  
Experimental Animals ◽  
Pathological Conditions

We will review the main animal models for the major neuropsychiatric disorders, focusing on schizophrenia, Alzheimer?s disease, Parkinson?s disease, depression, anxiety and autism. Although these mental disorders are specifically human pathologies and therefore impossible to perfectly replicate in animals, the use of experimental animals is based on the physiological and anatomical similarities between humans and animals such as the rat, and mouse, and on the fact that 99% of human and murine genomes are shared. Pathological conditions in animals can be assessed by manipulating the metabolism of neurotransmitters, through various behavioral tests, and by determining biochemical parameters that can serve as important markers of disorders.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

scholarly journals Post-status epilepticus treatment with the Fyn inhibitor, saracatinib, improves cognitive function in mice

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xin-Ming Luo ◽  
Jing Zhao ◽  
Wen-Yue Wu ◽  
Jie Fu ◽  
Zheng-Yu Li ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Cognitive Function ◽  
Cognitive Deficits ◽  
Tyrosine Kinases ◽  
Hippocampal Neurons ◽  
Water Maze ◽  
Behavioral Tests ◽  
Life Threatening ◽  
The Brain ◽  
Normal Object

Abstract Background Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits often result from hippocampal neurons lost after SE. Fyn, a non-receptor Src family of tyrosine kinases, is potentially associated with the onset of seizure. Saracatinib, a Fyn inhibitor, suppresses epileptogenesis and reduces epileptiform spikes. However, whether saracatinib inhibits cognitive deficits after SE is still unknown. Methods In the present study, a pilocarpine-induced SE mouse model was used to answer this question by using the Morris water maze and normal object recognition behavioral tests. Results We found that saracatinib inhibited the loss in cognitive function following SE. Furthermore, we found that the number of hippocampal neurons in the saracatinib treatment group was increased, when compared to the SE group. Conclusions These results showed that saracatinib can improve cognitive functions by reducing the loss of hippocampal neurons after SE, suggesting that Fyn dysfunction is involved in cognitive deficits after SE, and that the inhibition of Fyn is a possible treatment to improve cognitive function in SE patients.

Mouse Models of Schizophrenia and Bipolar Disorder

2013 ◽  
pp. 287-300
Author(s):  
Mikhail V. Pletnikov ◽  
Christopher A. Ross
Keyword(s):  
Bipolar Disorder ◽  
Animal Models ◽  
Mouse Models ◽  
Recent Progress ◽  
Neuropsychiatric Disorders ◽  
Environmental Interventions ◽  
The Future ◽  
Underlying Mechanisms ◽  
Insight Into ◽  
Genetic Mouse Models

Despite the recent advances in research into schizophrenia and bipolar disorder, the neurobiology of these maladies remains poorly understood. Animal models can be instrumental in elucidating the underlying mechanisms of neuropsychiatric disorders. Early animal models of schizophrenia and bipolar disorder used lesion methods, pharmacologic challenges or environmental interventions to mimic pathogenic features of the diseases. The recent progress in genetics has stimulated the development of etiological models that have begun to provide insight into pathogenesis. In this review, we evaluate the strengths and weaknesses of the existing genetic mouse models of schizophrenia and discuss potential developments for the future.

Sign in / Sign up

Export Citation Format

Share Document