scholarly journals Aspects of animal models for major neuropsychiatric disorders

2014 ◽  
Vol 66 (3) ◽  
pp. 1105-1115 ◽  
Author(s):  
Radu Lefter ◽  
Dumitru Cojocaru ◽  
Alin Ciobica ◽  
Manuel Paulet ◽  
Lacramioara Serban ◽  
...  
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Biochemical Parameters ◽  
Neuropsychiatric Disorders ◽  
Behavioral Tests ◽  
Experimental Animals ◽  
Pathological Conditions

We will review the main animal models for the major neuropsychiatric disorders, focusing on schizophrenia, Alzheimer?s disease, Parkinson?s disease, depression, anxiety and autism. Although these mental disorders are specifically human pathologies and therefore impossible to perfectly replicate in animals, the use of experimental animals is based on the physiological and anatomical similarities between humans and animals such as the rat, and mouse, and on the fact that 99% of human and murine genomes are shared. Pathological conditions in animals can be assessed by manipulating the metabolism of neurotransmitters, through various behavioral tests, and by determining biochemical parameters that can serve as important markers of disorders.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

scholarly journals New Horizons for Phenotyping Behavior in Rodents: The Example of Depressive-Like Behavior

2022 ◽  
Vol 15 ◽  
Author(s):  
Hugo Leite-Almeida ◽  
Magda J. Castelhano-Carlos ◽  
Nuno Sousa
Keyword(s):  
Animal Models ◽  
Treatment Strategies ◽  
Neuropsychiatric Disorders ◽  
Behavioral Neuroscience ◽  
Behavioral Tests ◽  
New Horizons ◽  
Study Behavior ◽  
Behavioral Parameters ◽  
Psychiatric Conditions ◽  
Neuroscience Community

The evolution of the field of behavioral neuroscience is significantly dependent on innovative disruption triggered by our ability to model and phenotype animal models of neuropsychiatric disorders. The ability to adequately elicit and measure behavioral parameters are the fundaments on which the behavioral neuroscience community establishes the pathophysiological mechanisms of neuropsychiatric disorders as well as contributes to the development of treatment strategies for those conditions. Herein, we review how mood disorders, in particular depression, are currently modeled in rodents, focusing on the limitations of these models and particularly on the analyses of the data obtained with different behavioral tests. Finally, we propose the use of new paradigms to study behavior using multidimensional strategies that better encompasses the complexity of psychiatric conditions, namely depression; these paradigms provide holistic phenotyping that is applicable to other conditions, thus promoting the emergence of novel findings that will leverage this field.

scholarly journals The Role of Iron in the Pathogenesis of Autism Spectrum Disorders in Children

2018 ◽  
Vol 17 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Olga V. Kostina
Keyword(s):  
Autism Spectrum Disorders ◽  
Iron Metabolism ◽  
Biochemical Parameters ◽  
Children With Autism ◽  
Neuropsychiatric Disorders ◽  
Perinatal Period ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
The Brain

The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.

Mouse Models of Schizophrenia and Bipolar Disorder

2013 ◽  
pp. 287-300
Author(s):  
Mikhail V. Pletnikov ◽  
Christopher A. Ross
Keyword(s):  
Bipolar Disorder ◽  
Animal Models ◽  
Mouse Models ◽  
Recent Progress ◽  
Neuropsychiatric Disorders ◽  
Environmental Interventions ◽  
The Future ◽  
Underlying Mechanisms ◽  
Insight Into ◽  
Genetic Mouse Models

Despite the recent advances in research into schizophrenia and bipolar disorder, the neurobiology of these maladies remains poorly understood. Animal models can be instrumental in elucidating the underlying mechanisms of neuropsychiatric disorders. Early animal models of schizophrenia and bipolar disorder used lesion methods, pharmacologic challenges or environmental interventions to mimic pathogenic features of the diseases. The recent progress in genetics has stimulated the development of etiological models that have begun to provide insight into pathogenesis. In this review, we evaluate the strengths and weaknesses of the existing genetic mouse models of schizophrenia and discuss potential developments for the future.

Animal Models

2018 ◽  
pp. 195-202
Author(s):  
Tadafumi Kato
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Neural Circuit ◽  
Chromosomal Abnormalities ◽  
Psychiatric Genetics ◽  
Genetic Animal Model ◽  
Animal Models Of Depression ◽  
Validity Criteria ◽  
New Treatment ◽  
Choice Of Species

Animal models of mental disorders are important for the development of new treatment and biomarkers. Animal models should satisfy three validity criteria. The choice of species used for animal models depends on the purposes of the study. There are several established models of chromosomal abnormalities for autism and schizophrenia. Stress-induced animal models of depression are controversial. There have been no established models for bipolar disorder, but the authors recently proposed a genetic animal model showing recurrent spontaneous depression-like episodes. Optogenetic manipulation of neural circuit is also used for modeling of mental disorders. Progress in psychiatric genetics will lead to the generation of valid animal models of psychiatric disorders.

Effect of Certain Head and Neck Tumors and Their Treatment on the Ventilatory Function of the Eustachian Tube and Hearing Loss

1983 ◽  
Vol 92 (6_suppl) ◽  
pp. 24-25
Author(s):  
E. N. Myers ◽  
Q. C. Beery ◽  
C. D. Bluestone ◽  
M. B. Möller ◽  
B. A. Sigler ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Animal Models ◽  
Cleft Palate ◽  
Head And Neck ◽  
Middle Ear ◽  
Clinical Condition ◽  
Ventilatory Function ◽  
Neck Tumors ◽  
Pathological Conditions ◽  
Middle Ear Disease

The management of patients with middle ear disease should be based on an understanding of the pathogenesis of the disease and its course. In this group of investigations, patients with pathological conditions such as cleft palate, which affects ET function, are studied. Animal models are then developed to simulate the clinical condition, thus providing a method of isolating the variables.

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