scholarly journals High Affinity Polymers by Molecular Imprinting for Drug Delivery

10.5772/50162 ◽  
2012 ◽  
Author(s):  
Mara Soares da Silva ◽  
Teresa Casimiro
Keyword(s):  
Drug Delivery ◽  
Molecular Imprinting ◽  
High Affinity

The Role of the Initiator System in the Synthesis of Acidic Multifunctional Nanoparticles Designed for Molecular Imprinting of Proteins

2020 ◽  
Vol 65 (1) ◽  
pp. 28-41
Author(s):  
Marwa Aly Ahmed ◽  
Júlia Erdőssy ◽  
Viola Horváth
Keyword(s):  
Acrylic Acid ◽  
Binding Affinity ◽  
Molecular Imprinting ◽  
Low Temperatures ◽  
Ammonium Persulfate ◽  
Sodium Bisulfite ◽  
Multifunctional Nanoparticles ◽  
High Affinity ◽  
Initiator System

Multifunctional nanoparticles have been shown earlier to bind certain proteins with high affinity and the binding affinity could be enhanced by molecular imprinting of the target protein. In this work different initiator systems were used and compared during the synthesis of poly (N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) nanoparticles with respect to their future applicability in molecular imprinting of lysozyme. The decomposition of ammonium persulfate initiator was initiated either thermally at 60 °C or by using redox activators, namely tetramethylethylenediamine or sodium bisulfite at low temperatures. Morphology differences in the resulting nanoparticles have been revealed using scanning electron microscopy and dynamic light scattering. During polymerization the conversion of each monomer was followed in time. Striking differences were demonstrated in the incorporation rate of acrylic acid between the tetramethylethylenediamine catalyzed initiation and the other systems. This led to a completely different nanoparticle microstructure the consequence of which was the distinctly lower lysozyme binding affinity. On the contrary, the use of sodium bisulfite activation resulted in similar nanoparticle structural homogeneity and protein binding affinity as the thermal initiation.

scholarly journals G-Quadruplex-Based Drug Delivery Systems for Cancer Therapy

2021 ◽  
Vol 14 (7) ◽  
pp. 671
Author(s):  
Jéssica Lopes-Nunes ◽  
Paula Oliveira ◽  
Carla Cruz
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nano Particles ◽  
Future Research ◽  
High Affinity ◽  
Dna And Rna ◽  
G Quadruplex ◽  
Gold Nano Particles

G-quadruplexes (G4s) are a class of nucleic acids (DNA and RNA) with single-stranded G-rich sequences. Owing to the selectivity of some G4s, they are emerging as targeting agents to overtake side effects of several potential anticancer drugs, and delivery systems of small molecules to malignant cells, through their high affinity or complementarity to specific targets. Moreover, different systems are being used to improve their potential, such as gold nano-particles or liposomes. Thus, the present review provides relevant data about the different studies with G4s as drug delivery systems and the challenges that must be overcome in the future research.

scholarly journals Computational modeling and molecular imprinting for the development of acrylic polymers with high affinity for bile salts

2010 ◽  
Vol 659 (1-2) ◽  
pp. 178-185 ◽  
Author(s):  
Fernando Yañez ◽  
Iva Chianella ◽  
Sergey A. Piletsky ◽  
Angel Concheiro ◽  
Carmen Alvarez-Lorenzo
Keyword(s):  
Computational Modeling ◽  
Molecular Imprinting ◽  
Bile Salts ◽  
Acrylic Polymers ◽  
High Affinity

scholarly journals Rapid and selective recognition of Vibrio parahaemolyticus assisted by perfluorinated alkoxysilane modified molecularly imprinted polymer film

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14305-14312 ◽  
Author(s):  
Kaiyue Fu ◽  
Huiwen Zhang ◽  
Yuanyuan Guo ◽  
Juan Li ◽  
Heran Nie ◽  
...  
Keyword(s):  
Polymer Film ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Vibrio Parahaemolyticus ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
High Affinity ◽  
Molecular Imprinting Technology

Molecular imprinting technology offers a means of tailor-made materials with high affinity and selectivity for certain analysts.

scholarly journals Molecular imprinting: A useful approach for drug delivery

2020 ◽  
Vol 3 ◽  
pp. 72-77 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Drug Delivery ◽  
Molecular Imprinting

Configurational biomimesis in drug delivery: molecular imprinting of biologically significant molecules

2004 ◽  
Vol 56 (11) ◽  
pp. 1599-1620 ◽  
Author(s):  
J.Zachary Hilt ◽  
Mark E. Byrne
Keyword(s):  
Drug Delivery ◽  
Molecular Imprinting

Design of thermoresponsive hydrogels by controlling the chemistry and imprinting of drug molecules within the hydrogel for enhanced loading and smart delivery of drugs

2021 ◽  
Author(s):  
Sang-Yu Park ◽  
Seong Yeol Kim ◽  
Ji-Hye Kang ◽  
Han-Sem Kim ◽  
Ueon Sang Shin
Keyword(s):  
Drug Delivery ◽  
Molecular Imprinting ◽  
Medical Practice ◽  
Drug Loading ◽  
Suitable Method ◽  
Drug Molecules ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Thermoresponsive Hydrogels ◽  
Delivery Techniques

Various drug delivery techniques have contributed significantly to medical practice. In particular, molecular imprinting is a suitable method to increase the drug-loading efficiency in limited 3D spaces, such as hydrogels....

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