scholarly journals Strategies to Develop Cyclodextrin-Based Nanosponges for Smart Drug Delivery

2021 ◽  
Author(s):  
Gjylije Hoti ◽  
Silvia Lucia Appleton ◽  
Alberto Rubin Pedrazzo ◽  
Claudio Cecone ◽  
Adrián Matencio ◽  
...  

In recent years, the development of various cyclodextrin (CD)-based nanosponges (NSs) has gained great importance in the controlled and-or targeted release of drugs due to their versatility and simple preparation. In this chapter, an introduction of different administration routes is explained. Further, different ways to obtain CD-NSs and their classification are shown with a brief explanation of the characterization of the inclusion complexes. Finally, illustrative examples in diverse processes or diseases will be reviewed and explained to demonstrate the potential of CD-NSs. Therefore, this division will serve to compile information on CD-NSs in recent years and to illustrate to readers how to generate and apply different derivatives of interest.

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.


Polymer ◽  
2017 ◽  
Vol 110 ◽  
pp. 235-241 ◽  
Author(s):  
Yanfang Hu ◽  
Ming Deng ◽  
Huailin Yang ◽  
Li Chen ◽  
Chunsheng Xiao ◽  
...  

2021 ◽  
Vol 63 ◽  
pp. 102433
Author(s):  
Sakshi Phogat ◽  
Abhishek Saxena ◽  
Neha Kapoor ◽  
Charu Aggarwal ◽  
Archana Tiwari

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Peipei Xu ◽  
Huaqin Zuo ◽  
Bing Chen ◽  
Ruju Wang ◽  
Arsalan Ahmed ◽  
...  

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