scholarly journals Protein Detection in Clinical Diagnosis and Management of Prevalent Neurodegenerative Diseases and Metabolic Disorders

2021 ◽  
Author(s):  
Ohanube A.K. Goodluck ◽  
Obeta M. Uchejeso ◽  
Ikeagwulonu R. Chinaza
Keyword(s):  
Diabetes Mellitus ◽  
Neurodegenerative Diseases ◽  
Metabolic Disorders ◽  
Protein Energy Malnutrition ◽  
Protein Detection ◽  
Cost Effective ◽  
Structure And Function ◽  
Accurate Diagnosis ◽  
Protein Energy ◽  
And Function

An accurate diagnosis gives leeway to cost-effective treatments. However, many diseases continue to evolve; hence, their etiology is sometimes missed due to the procedures used during diagnosis. Protein-related diseases include proteopathies (proteinopathies) such as neurodegenerative diseases and metabolic disorders like protein-energy malnutrition and some hormonopathies. Hormonopathies are associated with the change in the production of hormones. Diabetes mellitus, a type of hormonopathy, is reviewed in this work alongside neurodegenerative diseases and protein-energy malnutrition. This chapter aims to elucidate more on the diagnosis of these diseases considering the structure and function of their proteins viz-a-viz their deficiencies and hyper-production in man. Their pathogenesis and the principles underlying their diagnosis are further discussed to optimize the management of these diseases among patients.

scholarly journals Advances in high-density lipoprotein physiology: surprises, overturns, and promises

2016 ◽  
Vol 310 (1) ◽  
pp. E1-E14 ◽  
Author(s):  
Caterina Constantinou ◽  
Eleni A. Karavia ◽  
Eva Xepapadaki ◽  
Peristera-Ioanna Petropoulou ◽  
Eugenia Papakosta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Liver Disease ◽  
Metabolic Disorders ◽  
Density Lipoprotein ◽  
Pulmonary Diseases ◽  
Brain Disorders ◽  
Nonalcoholic Fatty Liver ◽  
Disease States ◽  
And Function

Emerging evidence strongly supports that changes in the HDL metabolic pathway, which result in changes in HDL proteome and function, appear to have a causative impact on a number of metabolic disorders. Here, we provide a critical review of the most recent and novel findings correlating HDL properties and functionality with various pathophysiological processes and disease states, such as obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, inflammation and sepsis, bone and obstructive pulmonary diseases, and brain disorders.

scholarly journals Association of Gestational Diabetes Mellitus With Left Ventricular Structure and Function: The CARDIA Study

Diabetes Care ◽  
2016 ◽  
Vol 39 (3) ◽  
pp. 400-407 ◽  
Author(s):  
Duke Appiah ◽  
Pamela J. Schreiner ◽  
Erica P. Gunderson ◽  
Suma H. Konety ◽  
David R. Jacobs ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Left Ventricular ◽  
Structure And Function ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
And Function

Left ventricular mass and function in children with severe protein energy malnutrition

1992 ◽  
Vol 35 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Shyam Sunder Kothari ◽  
Tejas M. Patel ◽  
Amulyaratha N. Shetalwad ◽  
Thakorebhai K. Patel
Keyword(s):  
Left Ventricular Mass ◽  
Protein Energy Malnutrition ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Protein Energy ◽  
And Function

Renal structure and function in insulin-dependent diabetes mellitus in man

1992 ◽  
Vol 10 (Supplement 1) ◽  
pp. S17-S20 ◽  
Author(s):  
S Michael Mauer ◽  
Pascale Lane ◽  
Dan Zhu ◽  
Paola Fioretto ◽  
Michael W. Steffes
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Structure And Function ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Renal Structure ◽  
Insulin Dependent ◽  
And Function

scholarly journals The Progress of Mitophagy and Related Pathogenic Mechanisms of the Neurodegenerative Diseases and Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Song ◽  
Wei Ding ◽  
Yan Xiao ◽  
Kong-jun Lu
Keyword(s):  
Neurodegenerative Diseases ◽  
Molecular Mechanism ◽  
Normal State ◽  
Mitochondrial Membrane ◽  
Eukaryotic Cell ◽  
Signal Pathway ◽  
Structure And Function ◽  
Regulation Mechanism ◽  
Energy Center ◽  
And Function

Mitochondrion, an organelle with two layers of membrane, is extremely vital to eukaryotic cell. Its major functions are energy center and apoptosis censor inside cell. The intactness of mitochondrial membrane is important to maintain its structure and function. Mitophagy is one kind of autophagy. In recent years, studies of mitochondria have shown that mitophagy is regulated by various factors and is an important regulation mechanism for organisms to maintain their normal state. In addition, abnormal mitophagy is closely related to several neurodegenerative diseases and tumor. However, the related signal pathway and its regulation mechanism still remain unclear. As a result, summarizing the progress of mitophagy and its related pathogenic mechanism not only helps to reveal the complicated molecular mechanism, but also helps to find a new target to treat the related diseases.

scholarly journals Pancreatic islets: some aspects of the morphology, physiology and destruction processes in diabetes mellitus type

2004 ◽  
Vol 50 (2) ◽  
pp. 3-10
Author(s):  
Yu. M. Kolesnik ◽  
M. A. Orlovskii
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islets ◽  
Structure And Function ◽  
Diabetes Mellitus Type ◽  
And Function ◽  
Development Structure

Modern views on the development, structure and function of pancreatic islets

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