scholarly journals Dimethylformamide Reduces Cerebral Ischaemia in Diabetic Rats Hours after Its Occurrence; A New Horizon

2018 ◽  
Author(s):  
Julio Amadeo Mendoza-Betancourt ◽  
Robert David Kross ◽  
Maria Angeles Moro ◽  
Ignacio Lizasoain ◽  
Luis Humberto Pérez-Astudillo ◽  
...  
Keyword(s):  
Cerebral Ischaemia ◽  
Diabetic Rats

scholarly journals Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats

2014 ◽  
Vol 41 (4) ◽  
pp. 498-503 ◽  
Author(s):  
Lin Tian ◽  
Yunqian Li ◽  
Wei Hua ◽  
Ying Jia ◽  
Min Zhou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cerebral Ischaemia ◽  
Artery Occlusion ◽  
Diabetic Rats ◽  
Focal Cerebral Ischaemia ◽  
Urotensin Ii ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Ischaemic Brain ◽  
Cerebral Ischemic

Background:The objective of this study was to explore the expression of urotensin II (UII), its receptor (GPR14), and vascular endothelial growth factor (VEGF), as well as their associations in the ischaemic brains of rats with focal cerebral ischaemia, under normal and diabetic conditions.Methods:Diabetes mellitus (DM) was induced by injection of streptozotocin (STZ) into Sprague—Dawley rats. Focal cerebral ischaemia was induced by middle cerebral artery occlusion (MCAO) four weeks after DM onset by STZ. Rats (n=80) were divided into four groups: normal control, DM, MCAO, and DM/MCAO. Immunohistochemistry and reverse-transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expression of UII, GPR14 and VEGF in the diabetic and ischaemic brain.Results:Expression of UII and GPR14 was increased at mRNA and protein levels in the DM and MCAO group compared with controls. In the DM/MCAO group, expression of UII and GPR14 was increased significantly in the ischaemic brain, and was accompanied by a significantly increased VEGF expression.Conclusion:Diabetes mellitus was seen to aggravate brain lesions after ischaemia, and UII may have an important role.

Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats

2016 ◽  
Vol 43 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Hongfei Sang ◽  
Ling Liu ◽  
Liumin Wang ◽  
Zhongming Qiu ◽  
Min Li ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cerebral Ischaemia ◽  
Diabetic Rats ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
B2 Receptors

Sites of Insulin Action Using Ferritin Labeling

1971 ◽  
Vol 29 ◽  
pp. 540-541
Author(s):  
Burton B. Silver ◽  
Ronald S. Nelson
Keyword(s):  
Electron Microscopy ◽  
Binding Sites ◽  
Anterior Pituitary ◽  
Insulin Action ◽  
Diabetic Rats ◽  
Insulin Antibody ◽  
Fat Pad ◽  
Target Organs ◽  
Uranium Salts ◽  
Sugar Levels

Some investigators feel that insulin does not enter cells but exerts its influence in some manner on the cell surface. Ferritin labeling of insulin and insulin antibody was used to determine if binding sites of insulin to specific target organs could be seen with electron microscopy.Alloxanized rats were considered diabetic if blood sugar levels were in excess of 300 mg %. Test reagents included ferritin, ferritin labeled insulin, and ferritin labeled insulin antibody. Target organs examined were were diaphragm, kidney, gastrocnemius, fat pad, liver and anterior pituitary. Reagents were administered through the left common carotid. Survival time was at least one hour in test animals. Tissue incubation studies were also done in normal as well as diabetic rats. Specimens were fixed in gluteraldehyde and osmium followed by staining with lead and uranium salts. Some tissues were not stained.

A PPARψ agonist improved diabetic state via decreasing TNF-α without any change including obesity in genetically obese diabetic rats

2001 ◽  
Vol 120 (5) ◽  
pp. A674-A674 ◽  
Author(s):  
A FUNAKOSHI ◽  
M ICHIKAWA ◽  
Y SATO ◽  
S KANAI ◽  
M OHTA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Diabetic State ◽  
Tnf Α ◽  
Obese Diabetic Rats

791: Endothelial Rehabilitation - The Impact of Chronic PDE5 Inhibitors on Erectile Function and Protein Alterations in Cavernous Tissue of Diabetic Rats

2007 ◽  
Vol 177 (4S) ◽  
pp. 264-265
Author(s):  
Ling De Young ◽  
KokBin Lim ◽  
Jeffery Carson ◽  
Trustin Domes ◽  
Mussa Al-Numi ◽  
...  
Keyword(s):  
Erectile Function ◽  
Diabetic Rats ◽  
Pde5 Inhibitors ◽  
Cavernous Tissue ◽  
Protein Alterations ◽  
The Impact

Abstract # P-9: Bauhinia Variegata Decreases Renal Damage in Streptozotocin Induced Diabetic Rats

2016 ◽  
Vol 22 ◽  
pp. 17-18
Author(s):  
Mayuresh S. Garud ◽  
Yogesh A. Kulkarni
Keyword(s):  
Renal Damage ◽  
Diabetic Rats ◽  
Bauhinia Variegata
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