Abstract # P-9: Bauhinia Variegata Decreases Renal Damage in Streptozotocin Induced Diabetic Rats

Renal damage secondary to diabetes seems to be related to the severity and duration of the diabetes. In streptozotocin and alloxan-induced diabetic rats, renal disease is found only in those rats that have glycosuria and then only after the glycosuria has been present for many months. In these animals, the longer they have glycosuria, the more severe the renal damage. In our colony of BB/S Wistar rats, animals that are going. to become frankly diabetic demonstrate clinical diabetes before they begin spilling glucose in their urine. After glycosuria develops, the condition of the animals worsens; yet, the glucose tolerance tests(GTT) remain essentially unchanged. The purpose of this investigation was to study the animals' kidneys to discover if lesions are present at the onset of glycosuria and how severe the lesions are.Rats of our BB/S Wistar strain were used the day they developed glycosuria. Similarly aged non-diabetic animals were used as controls.

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Long-term treatment with a beta-blocker timolol attenuates renal-damage in diabetic rats via enhancing kidney antioxidant-defense system

Molecular and Cellular Biochemistry ◽

10.1007/s11010-014-2123-2 ◽

2014 ◽

Vol 395 (1-2) ◽

pp. 177-186 ◽

Cited By ~ 6

Author(s):

Hilal Gokturk ◽

N. Nuray Ulusu ◽

Muslum Gok ◽

Erkan Tuncay ◽

Belgin Can ◽

...

Keyword(s):

Beta Blocker ◽

Renal Damage ◽

Antioxidant Defense ◽

Antioxidant Defense System ◽

Diabetic Rats ◽

Term Treatment ◽

Defense System ◽

Long Term Treatment

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Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Molecules ◽

10.3390/molecules23112812 ◽

2018 ◽

Vol 23 (11) ◽

pp. 2812 ◽

Cited By ~ 2

Author(s):

Adriana Rodríguez-Méndez ◽

Wendy Carmen-Sandoval ◽

Consuelo Lomas-Soria ◽

Ramón Guevara-González ◽

Rosalía Reynoso-Camacho ◽

...

Keyword(s):

Oxidative Stress ◽

Renal Damage ◽

Methanol Extract ◽

Serum Insulin ◽

Diabetic Rats ◽

Physiological Parameters ◽

Hypolipidemic Effect ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Uptake Activity

In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.

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