scholarly journals Antisense Oligonucleotides, A Novel Developing Targeting Therapy

2019 ◽  
Author(s):  
Sara Karaki ◽  
Clément Paris ◽  
Palma Rocchi
Keyword(s):  
Antisense Oligonucleotides ◽  
Targeting Therapy

scholarly journals RNA-targeting Therapy: A Promising Approach to Reach Non-Druggable Targets

2021 ◽  
Vol 14 (4) ◽  
pp. 1781-1790
Author(s):  
Dalia Zaafar ◽  
Toka Elemary ◽  
Yara Abdel Hady ◽  
Aya Essawy
Keyword(s):  
Antisense Oligonucleotides ◽  
New Technologies ◽  
Genetic Diseases ◽  
Disease Diagnosis ◽  
Targeting Therapy ◽  
Specific Targeting ◽  
Modern Drug ◽  
Rna Targeting ◽  
Druggable Targets ◽  
Promising Type

The term "non-druggable" refers to a protein that cannot be targeted pharmacologically; recently, significant efforts have been made to convert these proteins into targets that are reachable or "druggable." Pharmacologically targeting these difficult proteins has emerged as a major challenge in modern drug development, necessitating the innovation and development of new technologies. The idea of using RNA-targeting therapeutics as a platform to reach unreachable targets is very appealing. Antisense oligonucleotides, nucleic acid or aptamers, RNA interference therapeutics, microRNA, and synthetic RNA are examples of RNA-targeting therapeutics. Many of these agents were FDA-approved for the treatment of rare or genetic diseases, as well as molecular markers for disease diagnosis. As a promising type of therapeutic, many studies are being conducted in order for more and more of them to be approved and used in different disease treatments and to shift them from treating rare diseases only to being used as more specific targeting agents in the treatment of various common diseases. This article will look at some of the most recent technological and pharmaceutical advances that have contributed to the erosion of the concept of undruggability.

Clostridium difficile Infection: Associations with Chemotherapy, Radiation Therapy, and Targeting Therapy Treatments

2016 ◽  
Vol 23 (39) ◽  
pp. 4442-4449 ◽  
Author(s):  
Avi Peretz ◽  
Izhar Ben Shlomo ◽  
Orna Nitzan ◽  
Luigi Bonavina ◽  
Pmela M. Schaffer ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Targeting Therapy

Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?

2017 ◽  
Vol 23 (10) ◽  
pp. 1562-1570 ◽  
Author(s):  
Julia Schreml ◽  
Ioanna Gouni-Berthold
Keyword(s):  
Treatment Option ◽  
Antisense Oligonucleotides ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
New Treatment

Inhibition of dengue virus by novel, modified antisense oligonucleotides.

1995 ◽  
Vol 69 (1) ◽  
pp. 69-74 ◽  
Author(s):  
K Raviprakash ◽  
K Liu ◽  
M Matteucci ◽  
R Wagner ◽  
R Riffenburgh ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Antisense Oligonucleotides

Automated synthesis of PEG-coupled antisense-oligonucleotides

1993 ◽  
Vol 58 (s1) ◽  
pp. 204-208 ◽  
Author(s):  
Andres Jäschke ◽  
Jens P. Fürste ◽  
Dieter Cech ◽  
Volker A. Erdmann
Keyword(s):  
Antisense Oligonucleotides ◽  
Automated Synthesis
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