scholarly journals Introductory Chapter: Targeting Unmet Needs in Parkinson’s Disease

2019 ◽  
Author(s):  
Sara Palermo ◽  
Rosalba Morese ◽  
Mario Stanziano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unmet Needs

scholarly journals Social listening – revealing Parkinson’s disease over day and night

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zhang ◽  
Fanwen Meng ◽  
Xingyu Li ◽  
Yali Ning ◽  
Meng Cai
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unmet Needs ◽  
Unmet Need ◽  
Motor Symptoms ◽  
Motor Complications ◽  
Sentiment Score ◽  
Negative Sentiment ◽  
Non Motor Symptoms ◽  
Social Listening

Abstract Background Nocturnal symptoms in Parkinson’s disease are often treated after management of daytime manifestations. In order to better understand the unmet needs of nocturnal symptoms management, we analyzed the characteristics and burden of nocturnal symptoms from patients’ perspectives and explored their changes over time. Overall symptoms (occurring at day or night) were collected to compare whether the unmet needs related to nocturnal symptoms and to overall symptoms are different. Methods We used a Social Listening big-data technique to analyze large amounts of Parkinson’s disease symptoms in dialogues available from social media platforms in 2016 to 2018. These symptoms were classified as either overall symptoms or nocturnal symptoms. We used share of voice (SOV) of symptoms as a proportion of total dialogues per year to reflect the characteristics of symptoms. Negative sentiment score of symptoms was analyzed to find out their related burden. Results We found the SOV for overall motor symptoms was 79% and had not increased between 2016 and 2018 (79%, p = 0.5). The SOV for non-motor symptoms was 69% and had grown by 7% in 2018 (p <  0.01). The SOV for motor complications was 9% and had increased by 6% in 2018 (p <  0.01). The SOV of motor symptoms was larger than non-motor symptoms and motor complications (p <  0.01). The SOV of non-motor symptoms was larger than motor complications (p <  0.01). For nocturnal symptoms, 45% of the analyzed PD population reported nocturnal symptoms in 2018, growing by 6% (p <  0.01). The SOV for nocturnal-occurring motor symptoms was higher than most non-motor symptoms. However, non-motor symptoms had the higher increases and evoked higher negative sentiment regardless of whether they occurred during the day or night. For symptoms that can occur at either day or night, each nocturnal symptom was rated with a higher negative sentiment score than the same symptom during the day. Conclusions The growing SOV and the greater negative sentiment of nocturnal symptoms suggest management of nocturnal symptoms is an unmet need of patients. A greater emphasis on detecting and treating nocturnal symptoms with 24-h care is encouraged.

scholarly journals Unmet needs in Parkinson's disease: New horizons in a changing landscape

2016 ◽  
Vol 33 ◽  
pp. S2-S8 ◽  
Author(s):  
K. Ray Chaudhuri ◽  
Roongroj Bhidayasiri ◽  
Teus van Laar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unmet Needs ◽  
New Horizons

scholarly journals Unmet needs of people with Parkinson's disease

2021 ◽  
Vol 12 (2) ◽  
pp. 307-314
Author(s):  
Radka Kozáková ◽  
Radka Bužgová ◽  
Petra Bártová ◽  
Pavel Ressner
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unmet Needs

Progression of Parkinson’s Disease and Unmet Needs in Mid- to Late-stage Patients

2015 ◽  
Vol 10 (2) ◽  
pp. 182
Author(s):  
Heinz Reichmann ◽  
Paolo Barone ◽  
Werner Poewe ◽  
◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Late Stage ◽  
Unmet Needs ◽  
Early Stage ◽  
Early Morning ◽  
Motor Fluctuations ◽  
Phase Iii ◽  
Motor Symptoms ◽  
Beneficial Effects

In early-stage Parkinson’s disease (PD), dopaminergic treatment is highly effective in controlling motor symptoms. However, as the disease progresses, other symptoms and comorbidities need to be addressed, such as suboptimal motor control, emerging motor complications (e.g. nocturnal and early-morning akinesia/tremor, early wearing-off and dyskinesia), emerging levodopa-resistant motor symptoms, increasing non-motor symptoms and treatment of non-dopaminergic symptoms. Despite these unmet needs, no new therapies for PD have been introduced into routine clinical practice over the past 10 years. Safinamide is a new oral therapy that has both dopaminergic and non-dopaminergic mechanisms of action. In phase III clinical trials, safinamide has demonstrated significant clinical benefits in patients with mid- to late-stage PD experiencing motor fluctuations as an add-on therapy to levodopa and other PD medication versus those treated only on an optimised PD therapy. This includes improvements in daily ON time, improvements in motor function and beneficial effects on dyskinesia that have been studied in patients for up to 2 years. Safinamide is well tolerated, and it is a new and unique agent in the armamentarium of treatments for patients with mid- to late-stage PD experiencing motor fluctuations.

scholarly journals Cognitive impairment in Parkinson’s disease: a report from a multidisciplinary symposium on unmet needs and future directions to maintain cognitive health

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Jennifer G. Goldman ◽  
Beth A. Vernaleo ◽  
Richard Camicioli ◽  
Nabila Dahodwala ◽  
Roseanne D. Dobkin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Unmet Needs ◽  
Future Directions ◽  
Cognitive Health

Perceived unmet needs for health care among Parkinson's Society of New Zealand members with Parkinson's disease

2008 ◽  
Vol 14 (6) ◽  
pp. 495-500 ◽  
Author(s):  
Stephen Buetow ◽  
Lynne S. Giddings ◽  
Lisa Williams ◽  
Shoba Nayar
Keyword(s):  
Parkinson’S Disease ◽  
Health Care ◽  
Parkinson's Disease ◽  
New Zealand ◽  
Unmet Needs

Unmet needs of people with Parkinson’s disease: A cross‐sectional study

2019 ◽  
Vol 75 (12) ◽  
pp. 3504-3514 ◽  
Author(s):  
JuHee Lee ◽  
YonJi Kim ◽  
SungHae Kim ◽  
Yielin Kim ◽  
Young Joo Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unmet Needs ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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