scholarly journals Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

2020 ◽  
Author(s):  
Sunil Kumar ◽  
Pooja Dalal ◽  
Rekha Rao
Keyword(s):  
Drug Delivery ◽  
Cyclodextrin Nanosponges

Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes

2021 ◽  
pp. 102931
Author(s):  
Saeideh Allahyari ◽  
Fahimeh Zahednezhad ◽  
Mohamad Khatami ◽  
Nastaran Hashemzadeh ◽  
Parvin Zakeri-Milani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery ◽  
Cyclodextrin Nanosponges

Ester-Based Hydrophilic Cyclodextrin Nanosponges for Topical Ocular Drug Delivery

2017 ◽  
Vol 22 (46) ◽  
pp. 6988-6997 ◽  
Author(s):  
Zikhona Hayiyana ◽  
Yahya Choonara ◽  
Aubrey Makgotloe ◽  
Lisa Toit ◽  
Pradeep Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Cyclodextrin Nanosponges

Cyclodextrin Nanosponges in Drug Delivery and Nanotherapeutics

2018 ◽  
pp. 279-342 ◽  
Author(s):  
Riyaz Ali Osmani ◽  
Parthasarathi Kulkarni ◽  
Shringari Manjunatha ◽  
Vishakante Gowda ◽  
Umme Hani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cyclodextrin Nanosponges

scholarly journals Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver

2020 ◽  
Vol 65 ◽  
pp. 104800 ◽  
Author(s):  
Martina Daga ◽  
Inge A.M. de Graaf ◽  
Monica Argenziano ◽  
Ana Sofia Martinez Barranco ◽  
Maximillian Loeck ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transport Mechanisms ◽  
Cyclodextrin Nanosponges

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions

2009 ◽  
Vol 00 (00) ◽  
pp. 090810023617078-10 ◽  
Author(s):  
F. I. Kanaze ◽  
E. Kokkalou ◽  
I. Niopas ◽  
P. Barmpalexis ◽  
E. Georgarakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dissolution Rate ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stability Study
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