scholarly journals Electron Transfer-Supported Photodynamic Therapy

2020 ◽  
Author(s):  
Kazutaka Hirakawa
Keyword(s):  
Electron Transfer ◽  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Precancerous Lesions ◽  
Hypoxic Condition ◽  
Protein Damage ◽  
Free Base ◽  
Invasive Treatment ◽  
Porphyrin Derivatives ◽  
Mediated Oxidation

Photodynamic therapy (PDT) is a less-invasive treatment of cancer and precancerous lesions. Porphyrin derivatives have been used and studied as the photosensitizers for PDT. In general, the biomacromolecules oxidation by singlet oxygen, which is produced through energy transfer from the photoexcited photosensitizers to oxygen molecules, is an important mechanism of PDT. However, the traditional PDT effect may be restricted, because tumors are in a hypoxic condition and in certain cases, PDT enhances hypoxia via vascular damage. To solve this problem, the electron transfer-mediated oxidation of biomolecules has been proposed as the PDT mechanism. Specifically, porphyrin phosphorus(V) complexes demonstrate relatively strong photooxidative activity in protein damage through electron transfer. Furthermore, other photosensitizers, e.g., cationic free-base porphyrins, can oxidize biomolecules through electron transfer. The electron transfer-supported PDT may play the important roles in hypoxia cancer therapy. Furthermore, the electron transfer-supported mechanism may contribute to antimicrobial PDT. In this chapter, recent topics about the biomolecules photooxidation by electron transfer-supported mechanism are reviewed.

scholarly journals Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

2016 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Kotya Naik Maloth ◽  
Nagalaxmi Velpula ◽  
Srikanth Kodangal ◽  
Mithare Sangmesh ◽  
Kiran Vellamchetla ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Treatment Modality ◽  
Precancerous Lesions ◽  
Invasive Treatment ◽  
Non Invasive

Sequential, Ultrafast Energy Transfer and Electron Transfer in a Fused Zinc Phthalocyanine-free-base Porphyrin-C60 Supramolecular Triad

ChemPhysChem ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 163-172 ◽  
Author(s):  
Sairaman Seetharaman ◽  
Jorge Follana-Berná ◽  
Luis Martín-Gomis ◽  
Georgios Charalambidis ◽  
Adelais Trapali ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Energy Transfer ◽  
Zinc Phthalocyanine ◽  
Free Base

Modulation of Energy Transfer into Sequential Electron Transfer upon Axial Coordination of Tetrathiafulvalene in an Aluminum(III) Porphyrin–Free-Base Porphyrin Dyad

2015 ◽  
Vol 54 (17) ◽  
pp. 8482-8494 ◽  
Author(s):  
Prashanth K. Poddutoori ◽  
Lucas P. Bregles ◽  
Gary N. Lim ◽  
Patricia Boland ◽  
Russ G. Kerr ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Energy Transfer ◽  
Free Base ◽  
Axial Coordination ◽  
Sequential Electron

Energy Transfer and Electron Transfer of Poly(ethylene glycol)-Linked Fluorinated Porphyrin Derivatives in Lipid Bilayers

Langmuir ◽  
1996 ◽  
Vol 12 (2) ◽  
pp. 450-458 ◽  
Author(s):  
Kouji Iida ◽  
Mamoru Nango ◽  
Mitsutaka Matsuura ◽  
Masashi Yamaguchi ◽  
Kiyohito Sato ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Energy Transfer ◽  
Ethylene Glycol ◽  
Lipid Bilayers ◽  
Poly Ethylene Glycol ◽  
Porphyrin Derivatives ◽  
Poly Ethylene

scholarly journals Recent applications of porphyrins as photocatalysts in organic synthesis: batch and continuous flow approaches

2020 ◽  
Vol 16 ◽  
pp. 917-955 ◽  
Author(s):  
Rodrigo Costa e Silva ◽  
Luely Oliveira da Silva ◽  
Aloisio de Andrade Bartolomeu ◽  
Timothy John Brocksom ◽  
Kleber Thiago de Oliveira
Keyword(s):  
Electron Transfer ◽  
Energy Transfer ◽  
Electrochemical Properties ◽  
Organic Synthesis ◽  
Continuous Flow ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Porphyrin Derivatives ◽  
Enabling Technologies

In this review we present relevant and recent applications of porphyrin derivatives as photocatalysts in organic synthesis, involving both single electron transfer (SET) and energy transfer (ET) mechanistic approaches. We demonstrate that these highly conjugated photosensitizers show increasing potential in photocatalysis since they combine both photo- and electrochemical properties which can substitute available metalloorganic photocatalysts. Batch and continuous-flow approaches are presented highlighting the relevance of enabling technologies for the renewal of porphyrin applications in photocatalysis. Finally, the reaction scale in which the methodologies were developed are highlighted since this is an important parameter in the authors’ opinion.

scholarly journals Ultrafast Electron/Energy Transfer and Intersystem Crossing Mechanisms in BODIPY-Porphyrin Compounds

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 312
Author(s):  
Yusuf Tutel ◽  
Gökhan Sevinç ◽  
Betül Küçüköz ◽  
Elif Akhuseyin Yildiz ◽  
Ahmet Karatay ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescence Spectra ◽  
Visible Region ◽  
Energy Transfer Mechanism ◽  
Free Base ◽  
Pump Probe ◽  
Harvesting Efficiency ◽  
Probe Spectroscopy ◽  
Absorption Features ◽  
Transfer Mechanisms

Meso-substituted borondipyrromethene (BODIPY)-porphyrin compounds that include free base porphyrin with two different numbers of BODIPY groups (BDP-TTP and 3BDP-TTP) were designed and synthesized to analyze intramolecular energy transfer mechanisms of meso-substituted BODIPY-porphyrin dyads and the effect of the different numbers of BODIPY groups connected to free-base porphyrin on the energy transfer mechanism. Absorption spectra of BODIPY-porphyrin conjugates showed wide absorption features in the visible region, and that is highly valuable to increase light-harvesting efficiency. Fluorescence spectra of the studied compounds proved that BODIPY emission intensity decreased upon the photoexcitation of the BODIPY core, due to the energy transfer from BODIPY unit to porphyrin. In addition, ultrafast pump-probe spectroscopy measurements indicated that the energy transfer of the 3BDP-TTP compound (about 3 ps) is faster than the BDP-TTP compound (about 22 ps). Since the BODIPY core directly binds to the porphyrin unit, rapid energy transfer was seen for both compounds. Thus, the energy transfer rate increased with an increasing number of BODIPY moiety connected to free-base porphyrin.

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