scholarly journals Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach

2020 ◽  
Author(s):  
Rajesha K. Nairy ◽  
Nagesh N. Bhat ◽  
K.B. Anjaria ◽  
Usha Yadav ◽  
Rajesh Chaurasia ◽  
...  
Keyword(s):  
Gene Conversion ◽  
Proton Beam ◽  
Dose Response ◽  
Mathematical Formulation ◽  
Semiconductor Surface ◽  
Proton Radiation ◽  
Mathematical Formula ◽  
Ion Accelerator ◽  
Experimental Values ◽  
Folded Tandem Ion Accelerator

Proton being the easiest light ion to accelerate and achieve desired beam profile, has been pursued as a popular particulate radiation for therapy applications. In the present study, Saccharomyces cerevisiae D7 strain was used to estimate the RBE values of the 3 MeV proton beam, and an attempt was made to derive mathematical formula for calculating RBE value with respect to the dose. Dosimetry studies were carried out using Fricke dosimetry and Semiconductor Surface Barrier detector to calibrate the absorbed doses of Gamma chamber-1200 and Folded Tandem Ion Accelerator respectively. Gold standard cell survival assay and gene conversion assay were used to compare gamma and proton radiation induced cell death and genetic endpoint. Multi target single hit model was used to derive mathematical formula for RBE estimation. The results show a linear survival-dose response after proton radiation and sigmoid survival-dose response after gamma radiation treatment. The calculated RBE value from the survival and gene conversion studies was 1.60 and 3.93, respectively. The derived mathematical formula is very useful in calculating RBE value, which varies from 3.61 to 1.80 with increasing dose. The estimated RBE value from the mathematical formula is comparable with the experimental values. With the help of the present mathematical formulation, RBE value at any dose can be calculated in the exponential and sigmoidal regions of the survival curve without actually extending the experiment in that dose region, which is not possible using conventional methods.

PIXE STUDIES ON GOLD STANDARDS BY PROTONS OF ENERGY 3.3 MeV

2004 ◽  
Vol 14 (03n04) ◽  
pp. 141-146 ◽  
Author(s):  
DAISY JOSEPH ◽  
A. SAXENA ◽  
S. K. GUPTA ◽  
S. KAILAS
Keyword(s):  
Proton Beam ◽  
Energy Dispersive ◽  
X Rays ◽  
X Ray ◽  
Ion Accelerator ◽  
Folded Tandem Ion Accelerator ◽  
Certified Values ◽  
A Current ◽  
Gold Standards

Proton Induced X-ray Emission Technique (PIXE) has been used in analyzing Gold standards of 22, 20, 18, and 14 karats with a proton beam of Energy 3.3 MeV at the newly commissioned Folded Tandem Ion Accelerator (FOTIA) at B.A.R.C, Trombay. Well resolved Au and Ag X-rays were detected at a current of 3 nA . Percentage values of gold and silver were calculated and were checked with those obtained by Energy Dispersive X-ray Fluorescence (EDXRF) Method and were found to be in agreement with the certified values as well as those obtained by XRF.

scholarly journals A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1889
Author(s):  
Arthur Bongrand ◽  
Charbel Koumeir ◽  
Daphnée Villoing ◽  
Arnaud Guertin ◽  
Ferid Haddad ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Proton Beam ◽  
Dose Response ◽  
Small Animal ◽  
Absorbed Dose ◽  
Normal Tissue Damage ◽  
Dose Homogeneity ◽  
And Control ◽  
The Impact

Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. Another conclusion of this study is that Monte Carlo simulations can be used to help build preclinical lines in other setups.

Energy dependence and dose response of Gafchromic EBT2 film over a wide range of photon, electron, and proton beam energies

2010 ◽  
Vol 37 (5) ◽  
pp. 1942-1947 ◽  
Author(s):  
Bijan Arjomandy ◽  
Ramesh Tailor ◽  
Aman Anand ◽  
Narayan Sahoo ◽  
Michael Gillin ◽  
...  
Keyword(s):  
Proton Beam ◽  
Energy Dependence ◽  
Dose Response ◽  
Wide Range ◽  
Gafchromic Ebt2 Film ◽  
Ebt2 Film

Linear Dose Response of Gene Conversion in Saccharomyces cerevisiae after Ionizing Radiation

1981 ◽  
Vol 85 (2) ◽  
pp. 349 ◽  
Author(s):  
P. Unrau ◽  
F. K. Zimmermann ◽  
L. D. Johnson
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ionizing Radiation ◽  
Gene Conversion ◽  
Dose Response ◽  
Linear Dose

A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy

1992 ◽  
Vol 23 (1) ◽  
pp. 27-39 ◽  
Author(s):  
M.M. Urie ◽  
B. Fullerton ◽  
H. Tatsuzaki ◽  
S. Birnbaum ◽  
H.D. Suit ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Beam ◽  
Dose Response ◽  
Cranial Nerves ◽  
Response Analysis ◽  
Beam Radiation ◽  
Proton Beam Radiation ◽  
Proton Beam Radiation Therapy

scholarly journals Distinct vascular genomic response of proton and gamma radiation

2018 ◽  
Author(s):  
Ricciotti Emanuela ◽  
Dimitra Sarantopoulou ◽  
Gregory R. Grant ◽  
Jenine K. Sanzari ◽  
Gabriel S. Krigsfeld ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
Dose Response ◽  
Photon Radiation ◽  
Radiation Response ◽  
Whole Body ◽  
Proton Radiation ◽  
Vascular Effects ◽  
Radiation Induced ◽  
Total Body ◽  
Genomic Response

AbstractPurpose. The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge.Materials and methods.We performed comparative RNA sequencing of the aorta following (4 hrs) total-body proton and gamma irradiation (0.5 - 200 cGy whole body dose, 10 dose levels) of conscious mice. A trend analysis identified genes that showed a dose response.Results.While fewer genes were dose-responsive to proton than gamma radiation (29 vs. 194 genes;q-value ≤ 0.1), the magnitude of the effect was greater. Highly responsive genes were enriched for radiation response pathways (DNA damage, apoptosis, cellular stress and inflammation;p-value ≤ 0.01). Gamma, but not proton radiation induced additionally genes in vasculature specific pathways. Genes responsive to both radiation types showed almost perfectly superimposable dose-response relationships.Conclusions.Despite the activation of canonical radiation response pathways by both radiation types, we detected marked differences in the genomic response of the murine aorta. Models of cardiovascular risk based on photon radiation may not accurately predict the risk associated with proton radiation.

scholarly journals Repeatability and Reproducibility of Microdosimetry With a Mini-TEPC

2021 ◽  
Vol 9 ◽  
Author(s):  
A. Bianchi ◽  
A. Selva ◽  
P. Colautti ◽  
G. Petringa ◽  
P. Cirrone ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Proton Beam ◽  
Weighting Function ◽  
Physical Reality ◽  
Quality Assurance Program ◽  
Sensitive Volume ◽  
Proton Radiation ◽  
Radiation Quality ◽  
Repeatability And Reproducibility

Experimental microdosimetry measures the energy deposited in a microscopic sensitive volume (SV) by single ionizing particles traversing the SV or passing by. The fundamental advantage of experimental microdosimetry over the computational approach is that the first allows to determine distributions of energy deposition when information on the energy and nature of the charged particles at the point of interest is incomplete or fragmentary. This is almost always the case in radiation protection applications, but discrepancies between the modelled and the actual scenarios should be considered also in radiation therapy. Models for physical reality are always imperfect and rely both on basic input data and on assumptions and simplifications that are necessarily implemented. Furthermore, unintended events due to human errors or machine/system failures can be minimized but cannot be completely avoided.Though in proton radiation therapy (PRT) a constant relative biological effectiveness (RBE) of 1.1 is assumed, there is evidence of an increasing RBE towards the end of the proton penetration depth. Treatment Planning Systems (TPS) that take into account a variable linear energy transfer (LET) or RBE are already available and could be implemented in PRT in the near future. However, while the calculated dose distributions produced by the TPS are routinely verified with ionization chambers as part of the quality assurance program of every radiotherapy center, there is no commercial detector currently available to perform routine verification of the radiation quality, calculated by the TPS through LET or RBE distributions. Verification of calculated LET is required to make sure that a complex robustly optimized plan will be delivered as planned. The scientific community is coming to conclusion that a new domain of Quality Assurance additionally to the physical dose verification is required, and microdosimetry can be the right approach to address that. A first important prerequisite is the repeatability and reproducibility of microdosimetric measurements. This work aims at studying experimentally the repeatability and reproducibility of microdosimetric measurements performed with a miniaturized Tissue Equivalent Proportional Counter (mini-TEPC) in a 62 MeV proton beam. Experiments were carried out within 1 year and without propane gas recharging and by different operators. RBE was also calculated by applying the Loncol’s weighting function r(y) to microdosimetric distributions. Demonstration of reproducibility of measured microdosimetric quantities y¯F, y¯D and RBE10 in 62 MeV proton beam makes this TEPC a possible metrological tool for LET verification in proton therapy. Future characterization will be performed in higher energy proton beams.

scholarly journals Distributed UHV system for the folded tandem ion accelerator facility at BARC

2008 ◽  
Vol 114 ◽  
pp. 012022
Author(s):  
S K Gupta ◽  
A Agarwal ◽  
S K Singh ◽  
A Basu ◽  
Sapna P ◽  
...  
Keyword(s):  
Accelerator Facility ◽  
Ion Accelerator ◽  
Folded Tandem Ion Accelerator

Folded tandem ion accelerator facility at trombay

Pramana ◽  
2001 ◽  
Vol 57 (2-3) ◽  
pp. 639-650 ◽  
Author(s):  
P Singh
Keyword(s):  
Accelerator Facility ◽  
Ion Accelerator ◽  
Folded Tandem Ion Accelerator

MeV quasi-mono-energetic proton beam created by a combination of a laser-plasma ion accelerator and synchronous rf cavity

2008 ◽  
Author(s):  
M. Ikegami ◽  
S. Nakamura ◽  
Y. Iwashita ◽  
T. Shirai ◽  
H. Souda ◽  
...  
Keyword(s):  
Proton Beam ◽  
Laser Plasma ◽  
Energetic Proton ◽  
Rf Cavity ◽  
Ion Accelerator
Sign in / Sign up

Export Citation Format

Share Document