scholarly journals Recurrent Implantation Failure: The Role of Anatomical Causes

2021 ◽  
Author(s):  
Mariana Fonseca Roller Barcelos ◽  
Aluisio M. da Rocha Filho ◽  
Amanda Evelyn C. Goulart ◽  
Anna Luiza M. Souza ◽  
Daniely T. Costa ◽  
...  
Keyword(s):  
Negative Impact ◽  
Embryo Implantation ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization ◽  
Good Quality Embryo ◽  
Immunological Factors ◽  
Implantation Rates

Recurrent implantation failure (RIF) is one of the great challenges of current reproductive medicine. The term refers to the failure of repeated transfers of embryos of good morphological quality. Embryo implantation is a crucial moment in in vitro fertilization (IVF) treatments. A successful pregnancy depends on a synchronized interaction between a good quality embryo and a receptive endometrium. Its failure may be a consequence of embryo quality, anatomical or immunological factors. The anatomic causes constitute an important factor for RIF, although they are usually manageable. Fibroids, polyps and adhesions that develop after a surgical procedure or infection can hamper the embryo - endometrium attachment process. In addition, Mullerian abnormalities and hydrosalpinx can cause a negative impact on implantation rates and should also be taken into account in patients with RIF. In this chapter, we will address the main anatomical causes that may impact the implantation rates of patients undergoing IVF, as well as recommendations on management and its treatment.

scholarly journals The association of AGO1 (rs595961G>A, rs636832A>G) and AGO2 (rs11996715C>A, rs2292779C>G, rs4961280C>A) polymorphisms and risk of recurrent implantation failure

2019 ◽  
Vol 39 (11) ◽  
Author(s):  
Chang Soo Ryu ◽  
Young Ran Kim ◽  
Jung Oh Kim ◽  
Hui Jeong An ◽  
Sung Hwan Cho ◽  
...  
Keyword(s):  
Embryo Implantation ◽  
Recessive Model ◽  
Polymorphism Analysis ◽  
Implantation Failure ◽  
Dominant Model ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization ◽  
Argonaute 2 ◽  
Clinical Biomarkers

Abstract Recurrent implantation failure (RIF) is a common reproductive clinical condition treated by fertility specialists at in vitro fertilization (IVF) clinics. Several factors affect embryo implantation including the age of the female, the quality of embryos and the sperm, genetics, immunologic factors. Here, we investigated the association of Argonaute 1 (AGO1) and Argonaute 2 (AGO2) polymorphisms and RIF. We collected blood samples from 167 patients with RIF and 211 controls. Genetic polymorphisms were detected by polymerase chain reaction (PCR) – restriction fragment length polymorphism analysis and real-time PCR. We found that the AGO2 rs4961280C>A polymorphism (adjusted odds ratio [AOR] = 1.984; P = 0.023) was significantly associated with RIF. Furthermore, in RIF patients with three or more consecutive implantation failure, the AGO2 rs4961280C>A CA genotype (AOR = 2.133; P = 0.013) and dominant model (AOR = 2.272; P = 0.006) were both significantly associated with prevalence of RIF. An analysis of variance revealed that patients with the AGO2 rs2292779C>G genotypes (CC: 6.52 ± 2.55; CG: 7.46 ± 3.02; GG: 8.42 ± 2.74; P = 0.044) and the dominant model (CC: 6.52 ± 2.55; CG+GG: 7.70 ± 2.97; P = 0.029) exhibited significantly increased white blood cell levels. Furthermore, patients with the AGO1 rs595961G>A dominant model (GG: 36.81 ± 8.69; GA+AA: 31.58 ± 9.17; P = 0.006) and the AGO2 rs4961280C>A recessive model (CC+CA: 35.42 ± 8.77; AA: 22.00 ± 4.24; P = 0.035) exhibited a significantly decreased number of CD4+ helper T cells. Our study showed that AGO1 and AGO2 polymorphisms are associated with the prevalence of RIF. Hence, the results suggest that variations in AGO1 and AGO2 genotypes may be useful clinical biomarkers for the development and prognosis of RIF.

scholarly journals MicroRNA signatures in plasma and plasma exosome during window of implantation for implantation failure following in-vitro fertilization and embryo transfer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hong Zeng ◽  
Yu Fu ◽  
Lang Shen ◽  
Song Quan
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Embryo Implantation ◽  
Differentially Expressed ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization ◽  
Pathway Enrichment ◽  
Consistent Direction

Abstract Background MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood. Approximately 70% of embryos fail to implant following in-vitro fertilization and embryo transfer, 10% of patients experienced recurrent implantation failure. However, there are no well-established biomarkers that can predict implantation failure. Our purpose is to investigate distinct miRNA profiles in plasma and plasma exosomes during the window of implantation between patients with failed implantation and successful implantation. Methods We select a nested case-control population of 12 patients with implantation failure or successfully clinical pregnancy using propensity score matching. RNA was extracted from plasma and plasma exosomes collected during the window of implantation (WOI). MicroRNA expression in all samples was quantified using microRNA sequencing. The intersection of differently expressed miRNAs in plasma and exosomes were further validated in the GEO dataset. Significantly altered microRNAs in both plasma and plasma exosomes were then subjected to target prediction and KEGG pathway enrichment analyses to search for key signaling pathways. WGCNA analysis was performed to identify hub miRNAs associated with implantation. Results 13 miRNAs were differentially expressed in both plasma and plasma exosomes in patients with implantation failure. Among them, miR-150-5p, miR-150-3p, miR-149-5p, and miR-146b-3p had consistent direction changes in endometrium of patients with recurrent implantation failure (RIF), miR-342-3p had consistent direction changes in blood samples of patients with RIF. Pathway enrichment analysis showed that the target genes of differentially expressed miRNAs are enriched in pathways related to embryo implantation. WGCNA analysis indicated that miR-150-5p, miR-150-3p, miR-146b-3p, and miR-342-3p are hub miRNAs. Conclusions Implantation failure is associated with distinct miRNA profiles in plasma and plasma exosomes during WOI.

scholarly journals Anticoagulation and in vitro fertilization and ovarian stimulation

Hematology ◽  
2014 ◽  
Vol 2014 (1) ◽  
pp. 379-386 ◽  
Author(s):  
Shannon M. Bates
Keyword(s):  
Assisted Reproduction ◽  
Antithrombotic Therapy ◽  
Ovarian Hyperstimulation Syndrome ◽  
Reproductive Technology ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization ◽  
The Impact

Abstract Assisted reproductive technology is widely used to treat couples affected by infertility. Complications associated with assisted reproduction include venous thromboembolism, ovarian hyperstimulation syndrome, and recurrent implantation failure. It has also been proposed that thrombophilia may be associated with an increased likelihood of these events. Although data are limited, antithrombotic therapy is frequently used to enhance the likelihood of successful assisted reproduction. This chapter reviews the risks of venous and arterial thromboembolism associated with assisted reproduction, as well as available data regarding the impact of thrombophilia on the risks of thromboembolism and failure of implantation. The role of antithrombotic therapy in reducing the likelihood of these events, along with recommendations from various guidelines, are also discussed.

scholarly journals Association between HOX Transcript Antisense RNA Single-Nucleotide Variants and Recurrent Implantation Failure

2021 ◽  
Vol 22 (6) ◽  
pp. 3021
Author(s):  
Jeong Yong Lee ◽  
Eun Hee Ahn ◽  
Hyeon Woo Park ◽  
Ji Hyang Kim ◽  
Young Ran Kim ◽  
...  
Keyword(s):  
Antisense Rna ◽  
Coagulation Factors ◽  
Healthy Controls ◽  
Implantation Failure ◽  
Single Nucleotide Variants ◽  
Recurrent Implantation Failure ◽  
Single Nucleotide ◽  
Vitro Fertilization ◽  
And Control

Recurrent implantation failure (RIF) refers to the occurrence of more than two failed in vitro fertilization–embryo transfers (IVF-ETs) in the same individual. RIF can occur for many reasons, including embryo characteristics, immunological factors, and coagulation factors. Genetics can also contribute to RIF, with some single-nucleotide variants (SNVs) reported to be associated with RIF occurrence. We examined SNVs in a long non-coding RNA, homeobox (HOX) transcript antisense RNA (HOTAIR), which is known to affect cancer development. HOTAIR regulates epigenetic outcomes through histone modifications and chromatin remodeling. We recruited 155 female RIF patients and 330 healthy controls, and genotyped HOTAIR SNVs, including rs4759314, rs920778, rs7958904, and rs1899663, in all participants. Differences in these SNVs were compared between the patient and control groups. We identified significant differences in the occurrence of heterozygous genotypes and the dominant expression model for the rs1899663 and rs7958904 SNVs between RIF patients and control subjects. These HOTAIR variants were associated with serum hemoglobin (Hgb), luteinizing hormone (LH), total cholesterol (T. chol), and blood urea nitrogen (BUN) levels, as assessed by analysis of variance (ANOVA). We analyzed the four HOTAIR SNVs and found significant differences in haplotype patterns between RIF patients and healthy controls. The results of this study showed that HOTAIR is not only associated with the development of cancer but also with pregnancy-associated diseases. This study represents the first report showing that HOTAIR is correlated with RIF.

scholarly journals The Uterine Immune Profile May Help Women With Repeated Unexplained Embryo Implantation Failure After In Vitro Fertilization

2016 ◽  
Vol 75 (3) ◽  
pp. 388-401 ◽  
Author(s):  
Nathalie Lédée ◽  
Marie Petitbarat ◽  
Lucie Chevrier ◽  
Dominique Vitoux ◽  
Katia Vezmar ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Implantation ◽  
Implantation Failure ◽  
Vitro Fertilization ◽  
Immune Profile

Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization

2010 ◽  
Vol 93 (2) ◽  
pp. 437-441 ◽  
Author(s):  
Erika B. Johnston-MacAnanny ◽  
Janice Hartnett ◽  
Lawrence L. Engmann ◽  
John C. Nulsen ◽  
M. Melinda Sanders ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Chronic Endometritis ◽  
Vitro Fertilization ◽  
Frequent Finding

Endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization

2021 ◽  
Author(s):  
İrem Gülfem Albayrak ◽  
Fatemeh Azhari ◽  
Ezgi Nur Çolak ◽  
Burçin Karamustafaoğlu Balcı ◽  
Ege Ülgen ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Vitro Fertilization ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization

Clinical and immunological aspects of treatment women with repeated in-vitro fertilization failure

2014 ◽  
Vol 63 (5) ◽  
pp. 89-95
Author(s):  
Marina Ivanovna Krivonos ◽  
Marina Sabirovna Zaynulina ◽  
Sergey Vladimirovich Chepanov ◽  
Alexandr Vasilevich Selutin ◽  
Sergey Alekseevich Selkov ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Implantation Failure ◽  
Fertilization Failure ◽  
Vitro Fertilization ◽  
Repeated Implantation Failure ◽  
Assisted Reproductive Treatment ◽  
Immune Pathology

This review presents the existing literature concerning repeated implantation failure in assisted reproductive technologies. There are also discussed the role of immune pathology in the occurrence of repeated implantation failure in assisted reproductive treatment and the prospects of improving implantation rates with intravenous immunoglobulin in women with different immune pathologies.

Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome

2013 ◽  
Vol 100 (3) ◽  
pp. 825-830.e2 ◽  
Author(s):  
Carol Coughlan ◽  
Melanie Sinagra ◽  
William Ledger ◽  
T.C. Li ◽  
Susan Laird
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcome ◽  
Integrin Expression ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Vitro Fertilization
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