Role of Diffusion Tensor Imaging in Parkinson's Disease Diagnosis

Background: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease that affects the dopamine-containing neurons. In this study, the role of the Diffusion Tensor imaging (DTI) method was investigated in the detection of PD. Objectives: The purpose of this study was to investigate the microstructural damage of the brain's white matter in PD using a non-invasive DTI technique. Methods: Twenty patients with PD were studied with comprehensive clinical assessments and DTI data. Also, 10 normal subjects were investigated. Fractional anisotropic (FA) and mean diffusivity (MD) values were calculated by drawing region of interest (ROI) on eight distinctive areas of the brain. Results: The level of FA and MD in substantia nigra (SN) was significantly different between the PD and healthy control (HC) groups. Also, differences were found in DTI parameters between PD and HC groups in some regions, such as genu, anterior limb of internal capsule (ALIC), splenium, and putamen. Conclusions: To summarize, DTI as a non-invasive method can be useful in the detection of Parkinson's disease.

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Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson’s disease: diagnosis of gait abnormalities

Fluids and Barriers of the CNS ◽

10.1186/2045-8118-9-20 ◽

2012 ◽

Vol 9 (1) ◽

pp. 20 ◽

Cited By ~ 20

Author(s):

Kohei Marumoto ◽

Tetsuo Koyama ◽

Masashi Hosomi ◽

Norihiko Kodama ◽

Hiroji Miyake ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Diffusion Tensor Imaging ◽

Elderly Patients ◽

Normal Pressure Hydrocephalus ◽

Diffusion Tensor ◽

Normal Pressure ◽

Disease Diagnosis ◽

Idiopathic Normal Pressure Hydrocephalus ◽

Gait Abnormalities

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Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean diffusivity values

Neural Regeneration Research ◽

10.4103/1673-5374.213559 ◽

2017 ◽

Vol 12 (9) ◽

pp. 1485 ◽

Cited By ~ 5

Author(s):

Lan-xiang Liu ◽

Dan Du ◽

Tao Zheng ◽

Yuan Fang ◽

Yan-sheng Chen ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Diffusion Tensor Imaging ◽

Fractional Anisotropy ◽

Rat Model ◽

Diffusion Tensor ◽

Neuronal Degeneration ◽

Mean Diffusivity

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Deep Learning-Based Regional Sub-models Integration for Parkinson’s Disease Diagnosis Using Diffusion Tensor Imaging

10.1007/978-3-030-87358-5_60 ◽

2021 ◽

pp. 742-753

Author(s):

Hengling Zhao ◽

Chih-Chien Tsai ◽

Ce Zhu ◽

Mingyi Zhou ◽

Jiun-Jie Wang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Learning ◽

Diffusion Tensor Imaging ◽

Diffusion Tensor ◽

Disease Diagnosis

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Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease

Clinical EEG and Neuroscience ◽

10.1177/15500594211058263 ◽

2021 ◽

pp. 155005942110582

Author(s):

Sophie A. Stewart ◽

Laura Pimer ◽

John D. Fisk ◽

Benjamin Rusak ◽

Ron A. Leslie ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Diffusion Tensor Imaging ◽

Mild Cognitive Impairment ◽

White Matter ◽

Neurodegenerative Disorder ◽

Diffusion Tensor ◽

Early Stage ◽

White Matter Integrity

Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to established groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI.

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