Genotype 4 Hepatitis E Virus Prevalent in Eastern China Shows Diverse Subtypes

SUMMARYHepatitis E virus (HEV) is a zoonotic pathogen of which several species of animals are considered to be reservoirs. Thirty-eight faecal samples, obtained from 22 species of animals including birds in a wildlife first-aid centre in Eastern China, were tested for HEV RNA. Our survey revealed that in total 28·9% (95% confidence interval 14·5–43·4) of the faecal samples from various mammals and birds were HEV RNA positive. Sequence and phylogenetic analyses of the 11 isolates demonstrated that all sequences clustered in genotype 4 with 96–100% identity to each other. In addition, serum samples from seven animal handlers have shown that five (71·4%) were seropositive. The findings imply that cross-species infection of HEV had probably occurred in this zoo-like location, and moreover, birds can be infected naturally with mammalian HEV.

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Hepatitis E Virus Genotype Diversity in Eastern China

Emerging Infectious Diseases ◽

10.3201/eid1610.100873 ◽

2010 ◽

Vol 16 (10) ◽

pp. 1630-1632 ◽

Cited By ~ 40

Author(s):

Wen Zhang ◽

Yilin He ◽

Hua Wang ◽

Quan Shen ◽

Li Cui ◽

...

Keyword(s):

Hepatitis E Virus ◽

Eastern China ◽

Hepatitis E ◽

Virus Genotype ◽

Genotype Diversity

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Complete Genome Sequence of the Genotype 4 Hepatitis E Virus Strain Prevalent in Swine in Jiangsu Province, China, Reveals a Close Relationship with That from the Human Population in This Area

Journal of Virology ◽

10.1128/jvi.01060-12 ◽

2012 ◽

Vol 86 (15) ◽

pp. 8334-8335 ◽

Cited By ~ 11

Author(s):

H. Wang ◽

Y. He ◽

Q. Shen ◽

X. Wang ◽

S. Yang ◽

...

Keyword(s):

Genome Sequence ◽

Virus Strain ◽

Complete Genome Sequence ◽

Complete Genome ◽

Human Population ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Jiangsu Province ◽

Genotype 4 ◽

Close Relationship

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Seasonal pattern of hepatitis E virus prevalence in swine in two different geographical areas of China

Epidemiology and Infection ◽

10.1017/s0950268813000113 ◽

2013 ◽

Vol 141 (11) ◽

pp. 2403-2409 ◽

Cited By ~ 8

Author(s):

Y. H. LU ◽

H. Z. QIAN ◽

A. Q. HU ◽

X. QIN ◽

Q. W. JIANG ◽

...

Keyword(s):

Hepatitis E Virus ◽

Seasonal Pattern ◽

Eastern China ◽

Geographical Area ◽

Hepatitis E ◽

Southwestern China ◽

Seasonal Patterns ◽

Virus Prevalence ◽

Swine Hepatitis ◽

A Minor

SUMMARYWe studied seasonal patterns of swine hepatitis E virus (HEV) infection in China. From 2008 to 2011, 4200 swine bile specimens were collected for the detection of HEV RNA. A total of 92/2400 (3·83%) specimens in eastern China and 47/1800 (2·61%) specimens in southwestern China were positive for HEV. Seasonal patterns differing by geographical area were suggested. In eastern China, the major peak of HEV RNA prevalence was during March–April, with a minor peak during September–October, and a dip during July–August. In southwestern China, the peak was during September–October and the dip during March–April. The majority of subtype 4a cases (63/82, 76·83%) were detected in the first half of the year, while the majority of subtype 4b cases (26/29, 89·66%) were concentrated in the second half of the year, suggesting that different subtypes contribute to different peaks. Our results indicate that the distribution of HEV subtypes is associated with seasonal patterns.

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