scholarly journals Positive Peritoneal Cytology as a Predictor of Prognosis in Early Stage of Endometrioid Adenocarcinoma

2017 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Setare Akhavan ◽  
Zohre Kazemi ◽  
Abbas Alibakhshi ◽  
Mitra Modaresgilani ◽  
Azamsadat Mousavi ◽  
...  
Keyword(s):  
Early Stage ◽  
Peritoneal Cytology ◽  
Endometrioid Adenocarcinoma ◽  
Positive Peritoneal Cytology

Impact of surgical approach on prevalence of positive peritoneal cytology and lymph-vascular invasion in patients with early-stage endometrial carcinoma: a National Cancer Database study

2021 ◽  
pp. ijgc-2021-002445
Author(s):  
Dimitrios Nasioudis ◽  
Emily M Ko ◽  
Lori Cory ◽  
Nawar Latif
Keyword(s):  
Minimally Invasive Surgery ◽  
Minimally Invasive ◽  
Endometrial Carcinoma ◽  
Invasive Surgery ◽  
Surgical Approach ◽  
Vascular Invasion ◽  
Early Stage ◽  
Tumor Grade ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology

ObjectiveTo investigate the prevalence of positive peritoneal cytology and lymph-vascular invasion by surgical approach among patients with early stage endometrioid endometrial carcinoma undergoing hysterectomy.MethodsThe National Cancer Database was accessed and patients with FIGO stage I endometrioid endometrial carcinoma (with no history of another tumor diagnosed) who underwent simple hysterectomy (open or minimally invasive) between January 2010 and December 2015 and had available data on the presence of lymph-vascular invasion and/or status of peritoneal cytology were selected for further analysis. The impact of a surgical approach on the odds of lymph-vascular invasion and positive peritoneal cytology was calculated after controlling for tumor grade, size, and depth of myometrial invasion.ResultsA total of 74 732 patients who met the inclusion criteria were identified. The rate of minimally invasive hysterectomy was 75.7%. Data on peritoneal cytology status and lymph-vascular invasion were available for 50 185 and 71 641 patients, respectively. A higher proportion of patients who had minimally invasive hysterectomy had positive peritoneal cytology (4.4% vs 2.3%, p<0.001), and presence of lymph-vascular invasion (10.4% vs 9.2%, p<0.001). After controlling for tumor size, tumor grade, and disease substage, the performance of minimally invasive surgery was associated with higher odds of positive peritoneal cytology (OR 2.08, 95% CI 1.83 to 2.37) and presence of lymph-vascular invasion (OR 1.33, 95% CI 1.25 to 1.41). After controlling for confounders there was no difference in survival between open and minimally invasive surgery groups (HR 0.93, 95% CI 0.85 to 1.004).ConclusionsMinimally invasive surgery may be associated with a higher incidence of positive peritoneal cytology and lymph-vascular invasion among patients with early stage endometrioid endometrial cancer. There was no difference in overall survival between patients who had laparotomy or minimally invasive surgery.

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

A study of positive peritoneal cytology in patients with early-stage endometrial cancer

2020 ◽  
Vol 59 (3) ◽  
pp. 125-128
Author(s):  
Yoko NISHIMURA ◽  
Motoki MATSUURA ◽  
Masato TAMATE ◽  
Noriko TERADA ◽  
Seiro SATOHISA ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals The Risk of Lymph Node Metastasis With Positive Peritoneal Cytology in Endometrial Cancer

2013 ◽  
Vol 23 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Gunjal Garg ◽  
Feng Gao ◽  
Jason D. Wright ◽  
Andrea R. Hagemann ◽  
Israel Zighelboim ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Decision Making ◽  
Significant Risk ◽  
Serous Carcinoma ◽  
Peritoneal Cytology ◽  
Endometrioid Adenocarcinoma ◽  
Node Metastasis ◽  
Positive Peritoneal Cytology

ObjectiveTo determine the correlation between positive peritoneal cytology (PPC) and lymph node metastasis in patients with endometrial cancer grossly confined to the uterus.MethodsData were extracted from the Surveillance, Epidemiology, and End Results database between 1988 and 2005. Only patients with endometrial cancer grossly confined to the uterus who had undergone a complete staging procedure (lymph node removal) were included. Statistical analysis used the χ2test and logistic regression models.ResultsA total of 22,947 patients were identified. Positive peritoneal cytology was present in 3.5% of the patients. The incidence of lymph node metastasis was significantly higher among patients with PPC compared to those with negative peritoneal cytology for all histologic types examined (P< 0.0001): endometrioid adenocarcinoma, 28.7% versus 6.9%; adenocarcinoma not otherwise specified, 35.4% versus 5.8%; clear cell/serous carcinoma, 41.4% versus 19.0%, and carcinosarcoma,; 38.4% versus 14.4%. After adjusting for other contributing factors in the multivariable model, PPC remained an independent predictor of lymph node metastasis (P< 0.0001).ConclusionOur data indicate that patients with positive washings are at significant risk of nodal metastasis and adverse prognosis. Although no longer a part of the current International Federation of Gynecology and Obstetrics staging criteria, peritoneal cytology status should continue to inform clinical decision making in endometrial cancer.

scholarly journals Clinicopathological analysis of early endometrial cancers

2016 ◽  
Author(s):  
Seema Singhal ◽  
Sunesh Kumar Jain ◽  
D. N. Sharma ◽  
Sandeep Mathur ◽  
Juhi Bharti ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Endometrial Adenocarcinoma ◽  
Tertiary Care ◽  
Myometrial Invasion ◽  
Poor Correlation ◽  
Histopathological Analysis ◽  
Peritoneal Cytology ◽  
Type I ◽  
Positive Peritoneal Cytology

Aim: The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor assessment in early stage endometrial cancer. Materials and Methods: We conducted a prospective descriptive study of 30 cases of endometrial cancer stage 1 examined and treated at a tertiary care teaching institute between the years 2014-15. Results: The patients’ mean age at the time of diagnosis was 56.4 years. The mean parity was two. Postmenopausal bleeding with or without abnormal vaginal discharge was the most frequent symptom; it was present in 84.7% of patients. Co morbidities like hypertension and diabetes were seen in 65% of women. 6/30 patients had family history of some malignancy. All the patients underwent Type I extrafascial hysterectomy with bilateral salpingo oophorectomy, one case had Type I extrafascial hysterectomy with infracolic omentectomy. A total of 10.6% cases had lymph nodes metastasis and none of these patients had ovarian metastasis or positive peritoneal cytology. None of the patients with superficial myometrial invasion (MI) had lymph node metastasis. None of the cases showed positive peritoneal cytology. Staging upgraded fom 1a to 1b in 50% of subjects after final histopathological analysis. One patient who was operated as endometrial hyperplasia with atypia actually had endometrial adenocarcinoma in the postoperative specimen. Conclusions: There is a poor correlation between the preoperative and the postoperative tumor assessment.

scholarly journals Positive peritoneal cytology in early-stage endometrial cancer does not influence prognosis

2004 ◽  
Vol 91 (4) ◽  
pp. 720-724 ◽  
Author(s):  
P-M Tebeu ◽  
Y Popowski ◽  
H M Verkooijen ◽  
C Bouchardy ◽  
F Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer

2013 ◽  
Vol 128 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Gunjal Garg ◽  
Feng Gao ◽  
Jason D. Wright ◽  
Andrea R. Hagemann ◽  
David G. Mutch ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer
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