The Efficacy of N-acetilcysteine for the Treatment of the Metamfetamin-addicted Patients Under Methadon Therapy: A Double-blind Clinical Trial

2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Farzaneh Karami ◽  
Fateme Assarian ◽  
Fatemeh Sadat Ghoreishi ◽  
Mojtaba Sehat
Keyword(s):  
Methadone Treatment ◽  
Severity Index ◽  
Addiction Severity Index ◽  
Double Blind ◽  
Addiction Severity ◽  
Methamphetamine Dependence ◽  
Double Blind Clinical Trial ◽  
The Mean ◽  
To Receive ◽  
The Brain

Background: Methamphetamine dependence is a growing global problem. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. One of the alternatives to manage this addiction is the use of N acetylcysteine (NAC) due to its capacity to restore homeostasis in the brain glutamate systems disrupted in addiction and its ability to reduce craving and the risk of relapse. Methods: Methamphetamine‐dependent volunteers under methadone treatment (n = 38) were randomized to receive daily doses of 1200 mg of NAC, or placebo. The participants were followed for 12 weeks (two visits weekly). Craving and Beck Inventory Depression (BDI) was determined at the beginning of the study and also after one month, two months, and three months. Addiction severity index (ASI) was recorded at the beginning of the study and after three months. The data were analyzed via SPSS version 16.0 (SPSS Inc. Chicago, Illinios, USA) Results: The mean score of craving and BDI reduced after two months with NAC treatment. ASI (e.g., substance, familial, and psychiatric categories) was significantly reduced at the end of the study in the NAC group compared to placebo (P < 0.001). The success of the treatment in groups of NAC and placebo were 84% and 73%, respectively (P = 0.001). 63.2% of the NAC group patients avoided substance use for more than a month, but this was 10.5% in the placebo group (P = 0.001). Conclusions: The NAC showed good efficacy in suppressing methamphetamine craving, addiction severity index, and depression. It may be a useful pharmacological treatment for methamphetamine dependency.

scholarly journals Family Dysfunction Differentially Affects Alcohol and Methamphetamine Dependence: A View from the Addiction Severity Index in Japan

2011 ◽  
Vol 8 (10) ◽  
pp. 3922-3937 ◽  
Author(s):  
Nagisa Sugaya ◽  
Ayako Haraguchi ◽  
Yasukazu Ogai ◽  
Eiichi Senoo ◽  
Susumu Higuchi ◽  
...  
Keyword(s):  
Severity Index ◽  
Family Dysfunction ◽  
Addiction Severity Index ◽  
Addiction Severity ◽  
Methamphetamine Dependence

The formulation and efficacy of topical Dorema ammoniacum in treating Melasma: a randomized double-blind, placebo-controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Kani Javedan ◽  
Fatemeh Hydarpur ◽  
Pardis Mohammadi Pour ◽  
Fariba Najafi ◽  
Shahla Mirzaeei ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Sun Exposure ◽  
Herbal Product ◽  
Severity Index ◽  
P Value ◽  
Topical Formulation ◽  
Double Blind ◽  
The Mean ◽  
Product Effectiveness ◽  
To Receive

Abstract Objectives An acquired melanin-related hyperpigmentation that occurs in sun exposure areas is Melasma which presents as gray-brown ridges and macules with prominent margins on the skin. The aim of this assay was to assess the formulation and efficacy of topical Dorema ammoniacum among Melasma patients. Methods This study was a 30 days double-blind, randomized clinical trial in Melasma with a placebo group. The study was carried out on 49 patients with Melasma attending Haji Daii Nursing Center in Kermanshah, Iran. Optimized topical formulation of D. ammoniacum gum extract was prepared by evaluating the characteristics of different topical formulations of this plant. Mean Melasma severity index (MMASI) instrument was applied to assess the product effectiveness and to determine the skin stains. Patients were pursued to receive the treatment throughout the 30 days trial. This scaling was accomplished before the intervention and 30 days after the use of the herbal product. To analyze the quantitative variables, t-test and Mann–Whitney test were evaluated by SPSS 21 software, and p-value <0.05 was considered as the statistically significant. Results The survey was performed on 40 female subjects (81.6%) and nine male subjects (18.4%) with the mean age of 32.18 ± 8.69. According to the results, the mean MSI in the drug group was significantly lower than before treatment and decreased from 86.98 ± 69.48 to 31.03 ± 32.62 (p-value <0.05). Conclusions In compliance with findings this survey revealed a positive effect of the cream formulation of D. ammoniacum extract on Melasma. As it was represented no side effects, this formulation is appropriate for the treatment of Melasma.

The Antiaggressive Action of Combined Haloperidol-Propranolol Treatment in Schizophrenia

2000 ◽  
Vol 5 (4) ◽  
pp. 312-325 ◽  
Author(s):  
Gadi Maoz ◽  
Daniel Stein ◽  
Sorin Meged ◽  
Larisa Kurzman ◽  
Joseph Levine ◽  
...  
Keyword(s):  
Rating Scales ◽  
Double Blind ◽  
Propranolol Group ◽  
Schizophrenic Patients ◽  
Propranolol Treatment ◽  
Simultaneous Decrease ◽  
The Mean ◽  
Haloperidol Treatment ◽  
To Receive ◽  
Drug Free

Psychopharmacological interventions for managing aggression in schizophrenia have thus far yielded inconsistent results. This study evaluates the antiaggressive efficacy of combined haloperidol-propranolol treatment. Thirty-four newly admitted schizophrenic patients were studied in a controlled double-blind trial. Following a 3-day drug-free period and 7 days of haloperidol treatment, patients were randomly assigned to receive either haloperidol-propranolol or haloperidol-placebo for eight consecutive weeks. Doses of medications were adjusted as necessary; biperiden was administered if required. Rating scales were applied to assess aggression, anger, psychosis, depression, anxiety and extrapyramidal symptoms. The mean daily dose of haloperidol was 21 mg (SD = 6.4) in the research group and 29 mg (SD = 6.9) in the controls. Mean and maximal daily doses of propranolol were 159 mg (SD = 61) and 192 mg (SD = 83), and of placebo, 145 mg (SD = 50) and 180 mg (SD = 70), respectively. Compared with the controls, the scores for the research patients decreased significantly from baseline, particularly after 4 weeks of treatment, for some dimensions of anger, psychosis, anxiety, and neuroleptic-induced parkinsonism. A tendency for reduced aggression was shown in the combined haloperidol-propranolol group for some dimensions but not others. These patients also required significantly less biperiden. The tendency toward elevated antiaggressive effect of combined haloperidol-propranolol treatment compared to haloperidol alone may be explained by a simultaneous decrease in aggression, psychotic symptomatology, and anxiety.

Teen Addiction Severity Index

1991 ◽  
Author(s):  
Yifrah Kaminer ◽  
Oscar Bukstein ◽  
Ralph E. Tarter
Keyword(s):  
Severity Index ◽  
Addiction Severity Index ◽  
Addiction Severity

Predicting DSM-IV dependence diagnoses from Addiction Severity Index composite scores

2006 ◽  
Vol 31 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Samuel H. Rikoon ◽  
John S. Cacciola ◽  
Deni Carise ◽  
Arthur I. Alterman ◽  
A. Thomas McLellan
Keyword(s):  
Severity Index ◽  
Addiction Severity Index ◽  
Addiction Severity ◽  
Dsm Iv ◽  
Composite Scores

scholarly journals The prognosis of out-patient alcohol treatment among parents with childcare responsibility

BJPsych Open ◽  
2018 ◽  
Vol 4 (6) ◽  
pp. 471-477 ◽  
Author(s):  
Angelina Isabella Mellentin ◽  
Annette Elkjær Ellermann ◽  
Bent Nielsen ◽  
Anna Mejldal ◽  
Sören Möller ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Alcohol Treatment ◽  
Severity Index ◽  
Addiction Severity Index ◽  
Drop Out ◽  
Logistic Regression Models ◽  
Addiction Severity ◽  
Intention To Treat ◽  
Treatment Entry ◽  
Drinking Outcomes

BackgroundDespite expansive knowledge on the detrimental effects of growing up with parents with alcohol use disorders (AUDs), little is known about the prognosis of alcohol treatment among parents with childcare responsibility.AimsThis observational cohort study aimed to examine the prognosis of patients with and without childcare responsibility, in a conventional out-patient alcohol treatment clinic.MethodA consecutive AUD sample (N = 2201), based on ICD-10 Diagnostic Criteria for Research, was assessed with the European Addiction Severity Index during the clinical routine, at treatment entry and conclusion. Data on addiction severity, treatment course and drinking outcomes were derived, and adjusted odds ratios (AORs) were calculated with logistic-regression models. Drinking outcomes were compared in an intention-to-treat analysis, including all patients in a logistic regression with inverse probability weighting.ResultsPatients with childcare responsibility (aged <18 years) had a less severe addiction profile and lower drop-out rate compared with patients without children or with children living out-of-home. They were also more likely to improve on all drinking-related outcomes, including abstinence (AOR 2.68, 95% CI 1.82–3.95), number of drinking days (AOR 2.45, 95% CI 1.50–4.03) and excessive drinking days (AOR 4.66, 95% CI 2.36–9.17); and those with children living out-of-home had better outcomes on abstinence (AOR 1.59, 95% CI 1.08–2.34) than patients without children.ConclusionsChildcare responsibility among out-patients was associated with better treatment course and outcomes than those without or not living with their children. This knowledge can help guide clinical practice, effectuate interventions and inform social authorities.

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