A Rose by Any Other Name…

2020 ◽  
Vol 17 (2) ◽  
pp. 239-282
Author(s):  
Paolo C. Biondi ◽  

The question of how, according to Aristotle, the principles of science are acquired remains contested among scholars. An aspect of this broader topic concerns the role of induction, and whether it is able to provide us with knowledge of natural necessity without the assistance of intuition (nous). In a recent publication in this journal, David Botting argues in favour of the enumerative/empiricist interpretation of induction and criticizes the intuitive/rationalist interpretation of it, a version of which was defended in one of my publications. He thinks that Aristotle is like Hume: both understand the cognitive process of induction similarly; and, both are equally skeptical about acquiring knowledge of natural necessity through induction. My reply argues that reading Aristotle’s induction in Humean terms is problematic in several respects. I argue, in addition, that natural necessity can be known through induction if nous is involved. My explanation of how this is possible relies on thinking of the act of noēsis in terms of an act of recognition. Botting claims, furthermore, that Aristotle only differs from Hume in that the former does have a non-inductive and non-intuitive method by which natural necessity may become known, and which Botting calls “the constructive proof of necessity”. My reply examines this method, showing how certain steps in it rely on cognitive acts that are really acts of intuition merely expressed in Humean terms. Despite the criticisms, I end with suggestions for how Botting’s account might offer original paths of research to Aristotle scholars seeking to answer the question of the acquisition of principles of science, particularly in the early stages of this process.

Author(s):  
Lucia Dacome

Chapter 7 furthers the analysis of the role of anatomical models as cultural currencies capable of transferring value. It does so by expanding the investigation of the early stages of anatomical modelling to include a new setting. In particular, it follows the journey of the Palermitan anatomist and modeller Giuseppe Salerno and his anatomical ‘skeleton’—a specimen that represented the body’s complex web of blood vessels and was presented as the result of anatomical injections. Although Salerno was headed towards Bologna, a major centre of anatomical modelling, he ended his journey in Naples after the nobleman Raimondo di Sangro purchased the skeleton for his own cabinet of curiosities. This chapter considers the creation and viewing of an anatomical display in di Sangro’s Neapolitan Palace from a comparative perspective that highlights how geography and locality played an important part in shaping the culture of mid-eighteenth-century anatomical modelling.


2011 ◽  
Vol 46 (1) ◽  
pp. 32-55 ◽  
Author(s):  
Michael Holmes ◽  
Simon Lightfoot

AbstractThis article looks at the role of the Party of European Socialists (PES) in its attempts to shape social democratic parties in Central and Eastern Europe (CEE) towards a West European norm. It discusses how existing views in the academic literature on the role of transnational parties are inadequate. We argue that the PES did not play a key role in encouraging the establishment and development of parties in the CEE states from the 2004 enlargement in the early stages of accession. We contend that the overall influence of party federations has been limited, and that these limitations were as much in evidence before enlargement took place as they were afterwards.


2012 ◽  
Vol 49 (3) ◽  
pp. R149-R156 ◽  
Author(s):  
Jaume Folch ◽  
Ignacio Pedrós ◽  
Iván Patraca ◽  
Francesc Sureda ◽  
Fèlix Junyent ◽  
...  

Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downstream molecules involved in key pathways related to cell survival such as STAT3, PI3K, MAPK, AMPK, CDK5 and GSK3β. Collectively, these pathways act in a coordinated manner and form a network that is fully involved in Lep physiological response. Although the major interest in Lep is related to its role in the regulation of energy balance, and since resistance to Lep affects is the primary risk factor for obesity, the interest on their effects on brain cognition and neuroprotection is increasing. Thus, Lep and Lep mimetic compounds now await and deserve systematic exploration as the orchestrator of protective responses in the nervous system. Moreover, Lep might promote the activation of a cognitive process that may retard or even partially reverse selected aspects of Alzheimer's disease or ageing memory loss.


2021 ◽  
Vol 50 (10) ◽  
pp. 104349
Author(s):  
Markus C. Becker ◽  
Francesco Rullani ◽  
Francesco Zirpoli

2020 ◽  
Vol 9 (1) ◽  
pp. 45
Author(s):  
María del Carmen Molina ◽  
James F. White ◽  
Sara García-Salgado ◽  
M. Ángeles Quijano ◽  
Natalia González-Benítez

So far, the relative importance of the plant and its microbiome in the development of early stages of plant seedling growth under arsenic stress has not been studied. To test the role of endophytic bacteria in increasing plant success under arsenic stress, gnotobiotic seeds of J. montana were inoculated with two endophytic bacteria: Pantoea conspicua MC-K1 (PGPB and As resistant bacteria) and Arthrobacter sp. MC-D3A (non-helper and non-As resistant bacteria) and an endobacteria mixture. In holobiotic seedlings (with seed-vectored microbes intact), neither the capacity of germination nor development of roots and lateral hairs was affected at 125 μM As(V). However, in gnotobiotic seedlings, the plants are negatively impacted by absence of a microbiome and presence of arsenic, resulting in reduced growth of roots and root hairs. The inoculation of a single PGPB (P. conspicua-MCK1) shows a tendency to the recovery of the plant, both in arsenic enriched and arsenic-free media, while the inoculation with Arthrobacter sp. does not help in the recovery of the plants. Inoculation with a bacterial mixture allows recovery of plants in arsenic free media; however, plants did not recover under arsenic stress, probably because of a bacterial interaction in the mixture.


Development ◽  
1991 ◽  
Vol 113 (Supplement_2) ◽  
pp. 59-62 ◽  
Author(s):  
M. Angela Nieto ◽  
Leila C. Bradley ◽  
David G. Wilkinson

The zinc-finger gene Krox-20 is expressed in two alternating segments, rhombomeres (r) 3 and 5, in the developing mouse hindbrain. This expression pattern is established prior to rhombomere formation in the mouse, but it is not known how the timing of expression relates to cellular events of segmentation, such as lineage restriction. We have cloned Krox-20 sequences from Xenopus and the chick and shown that its alternating expression pattern is conserved in these systems, suggesting that its role in hindbrain development is conserved. Analysis of the early stages of Krox-20 expression in the chick show that both domains of expression precede the restriction of cell lineage to specific rhombomeres, consistent with a role of this gene in early events of hindbrain segmentation. The finding that expression is not coincident with lineage restriction indicates that early expression may not reflect an irreversible commitment of cells to r3 and r5 and/or may be mosaic.


2017 ◽  
Vol 42 (6) ◽  
pp. 1277-1289 ◽  
Author(s):  
Mariana Charleaux de Ponte ◽  
Fernando Augusto Malavazzi Casare ◽  
Juliana Martins Costa-Pessoa ◽  
Vanessa Gerolde Cardoso ◽  
Gerhard Malnic ◽  
...  
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