Anterior Diffuse Retinoblastoma: Mutational Analysis and Immunofluorescence Staining
2009 ◽
Vol 133
(8)
◽
pp. 1215-1218
Keyword(s):
Factor Α
◽
Abstract Retinoblastoma is the most common primary intraocular tumor of childhood and may be heritable or occur sporadically. Anterior diffuse retinoblastoma is an uncommon variant that is thought to be sporadic. We describe a child with anterior diffuse retinoblastoma who presented with a pseudohypopyon. Genetic analysis showed a germline mutation of the RB1 allele that is potentially heritable. Immunofluorescence staining was positive for transforming growth factor β and for vascular endothelial growth factor and negative for inducible nitric oxide synthase and for hypoxia inducible factor α in the tumor seeds, indicating acquisition of nonischemia-mediated survival factors of the tumor seeds in the aqueous humor.
2005 ◽
Vol 84
(9)
◽
pp. 887-893
◽
2001 ◽
Vol 61
(8)
◽
pp. 947-954
◽
2002 ◽
Vol 160
(1)
◽
pp. 381-383
◽
2004 ◽
Vol 14
(1)
◽
pp. 82-88
2010 ◽
Vol 16
(11)
◽
pp. 3375-3383
◽