scholarly journals Five Top Stories in Cytopathology

2013 ◽  
Vol 137 (7) ◽  
pp. 894-906 ◽  
Author(s):  
Andrew H. Fischer ◽  
Cynthia C. Benedict ◽  
Mojgan Amrikachi
Keyword(s):  
Cancer Biology ◽  
Imaging Techniques ◽  
Cost Effective ◽  
Active Role ◽  
Needle Aspiration ◽  
New Techniques ◽  
Health Care Outcomes ◽  
Fine Needle ◽  
Molecular Tests ◽  
Care Outcomes

Context.—Cytology relies heavily on morphology to make diagnoses, and morphologic criteria have not changed much in recent years. The field is being shaped predominantly by new techniques for imaging and for acquiring and processing samples, advances in molecular diagnosis and therapeutics, and regulatory issues. Objective.—To review the importance of classical morphology in the future of cytopathology, to identify areas in which cytology is expanding or contracting in its scope, and to identify factors that are shaping the field. Data Sources.—Literature review. Conclusions.—Five stories paint a picture in which classical cytomorphology will continue to have essential importance, both for diagnosis and for improving our understanding of cancer biology. New endoscopy and imaging techniques are replacing surgical biopsies with cytology samples. New molecularly targeted therapies offer a chance for cytology to play a major role, but they pose new challenges. New molecular tests have the potential to synergize with, but not replace, morphologic interpretation of thyroid fine-needle aspirations. Ultrasound-guided fine-needle aspiration performed by cytopathologists is opening a new field of “interventional cytopathology” with unique value. For the productive evolution of the field, it will be important for cytopathologists to play an active role in clinical trials that document the ability of cytology to achieve cost-effective health care outcomes.

scholarly journals Evaluation of Peritoneal Deposits in Undiagnosed Ascites by Advanced Endoscopic Ultrasound Imaging Techniques

2021 ◽  
Vol 12 (01) ◽  
pp. 049-050
Author(s):  
Surinder Singh Rana ◽  
Ravi Sharma ◽  
Rajesh Gupta
Keyword(s):  
Ascitic Fluid ◽  
Endoscopic Ultrasound ◽  
Imaging Techniques ◽  
Needle Aspiration ◽  
Enhancement Pattern ◽  
Etiological Diagnosis ◽  
Fine Needle ◽  
Contrast Enhanced ◽  
Biochemical Evaluation ◽  
Repeat Sampling

AbstractEtiology of ascites can be usually determined with ascitic fluid cytological and biochemical evaluation. Occasionally, the cause of ascites cannot be determined despite repeated ascitic fluid evaluations. These patients with undiagnosed ascites usually undergo diagnostic laparotomy/laparoscopy for etiological diagnosis. Endoscopic ultrasound (EUS) can help in resolving the diagnostic conundrum of undiagnosed ascites by visualizing as well as sampling peritoneal and omental deposits/thickening. However, rarely fine-needle aspiration from deposits may be falsely negative and patient may need repeat sampling. Newer EUS imaging techniques such as elastography and contrast-enhanced harmonic EUS by providing additive information on stiffness and enhancement pattern of the lesion can help in differential diagnosis.

scholarly journals Punção Aspirativa de Nódulos da Tiroide: Vale a Pena Repetir?

2017 ◽  
Vol 30 (6) ◽  
pp. 472
Author(s):  
Vera Fernandes ◽  
Tânia Pereira ◽  
Catarina Eloy
Keyword(s):  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Significant Proportion ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Fine Needle ◽  
High Concordance ◽  
Benign Nodules ◽  
Cytology Result ◽  
Undetermined Significance

Introduction: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results.Material and Methods: Retrospective study of the 4800 thyroid nodules fine-needle aspiration held in Instituto de Patologia e Imunologia Molecular da Universidade do Porto between January 1, 2014 and May 2, 2016. Of the initial sample, we selected the repeated fine-needle aspiration on the same nodule.Results: The first fine-needle aspiration result of the 309 nodules underwent revaluation was non-diagnostic in 103 (33.3%), benign in 120 (38.8%) and atypia/follicular lesion of undetermined significance in 86 (27.8%). The agreement between the first and second fine-needle aspiration was significantly higher in cases with an initial benign result (benign: 85.8%, non-diagnostic: 27.2% and atypia/ follicular lesion of undetermined significance: 17.4%, p < 0.005). The fine-needle aspiration repeating motifs in initially benign nodules (n = 78) were repetition suggestion in 58, nodule growth in 17 and suspicious ultrasonographic features in 3.Discussion: The fine-needle aspiration repetition in nodules with initial non-diagnostic and atypia/follicular lesion of undetermined significance result changed the initial diagnosis in a significant proportion of patients, modifying their therapeutic approach. The high concordance of results in initially benign nodules makes fine-needle aspiration repetition not cost-effective in most cases.Conclusion: The fine-needle aspiration should be repeated when the initial cytology result is non-diagnostic or atypia/follicular lesion of undetermined significance.

scholarly journals Diagnosis of Infectious Diseases: a Cytopathologist’s Perspective

1998 ◽  
Vol 11 (2) ◽  
pp. 341-365 ◽  
Author(s):  
Celeste N. Powers
Keyword(s):  
Infectious Diseases ◽  
Fine Needle Aspiration ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Clinical Correlation ◽  
Fine Needle ◽  
Presumptive Identification ◽  
Staining Methods

SUMMARY This review explores the role of the cytopathology laboratory in the detection and presumptive identification of microorganisms. Sample procurement by exfoliation, abrasion, and aspiration techniques, as well as a variety of cytopreparatory and staining methods, is reviewed. Emphasis is placed on the utility of fine-needle aspiration as a rapid, safe, and cost-effective diagnositic procedure. The role of rapid interpretation and specimen triage is also discussed. Cytomorphologic features and staining characteristics are presented for a spectrum of microorganisms potentially encountered in the cytopathology laboratory. Pitfalls in diagnosis and the usefulness of special stains and ancillary techniques are also evaluated. The importance of communication, collaboration, and clinical correlation is stressed.

scholarly journals Fine-Needle Aspiration Followed by Core-Needle Biopsy in the Same Setting: Modifying Our Approach

2016 ◽  
Vol 60 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Amani A. Joudeh ◽  
Sameera Q. Shareef ◽  
Mousa A. Al-Abbadi
Keyword(s):  
Fine Needle Aspiration ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Diagnostic Procedure ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Patient Centered ◽  
Core Needle ◽  
Fine Needle ◽  
Second Procedure

Fine-needle aspiration biopsy (FNAB) is a well-established initial diagnostic tool. However, in some instances limitations and shortcomings arise, making it insufficient for determining a specific diagnosis. Consequently, patients have to undergo another diagnostic procedure. The second procedure is either repeat FNAB, core-needle or open biopsy, and can be inconvenient and costly. In some centers, the FNAB is immediately followed by core-needle biopsy (CNB) in the same setting after assuring adequacy on the initial FNAB utilizing rapid on-site specimen evaluation (ROSE). It is argued that implementing such an approach will eventually have additional critical advantages that include the following: (a) it is more convenient to patients to have both procedures in one visit, (b) the tissue procured by both procedures will be more adequate, enabling cytopathologists to reach an accurate diagnosis, and (c) it is ultimately a cost-effective approach if we take into consideration the avoidance of a potential second more invasive diagnostic procedure. Since we are living in an era of patient-centered medicine coupled with cost-cutting strategies, we present here a brief review of the topic with analysis of this alternative approach, review of the pertinent literature and shed light on a few scenarios that justify this approach.

scholarly journals A review of techniques for detecting Huanglongbing (greening) in citrus

2016 ◽  
Vol 62 (10) ◽  
pp. 803-811 ◽  
Author(s):  
Roberto Arredondo Valdés ◽  
Juan C. Delgado Ortiz ◽  
Mariana Beltrán Beache ◽  
Julia Anguiano Cabello ◽  
Ernesto Cerna Chávez ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Cost Effective ◽  
Molecular Techniques ◽  
New Techniques ◽  
Plant Volatile ◽  
Volatile Organic ◽  
Candidatus Liberibacter ◽  
Polymerase Chain ◽  
Potential Methods ◽  
No Sensor

Huanglongbing (HLB) is the most destructive disease of citrus worldwide. Monitoring of health and detection of diseases in trees is critical for sustainable agriculture. HLB symptoms are virtually the same wherever the disease occurs. The disease is caused by Candidatus Liberibacter spp., vectored by the psyllids Diaphorina citri Kuwayama and Trioza erytreae. Electron microscopy was the first technique used for HLB detection. Nowadays, scientists are working on the development of new techniques for a rapid HLB detection, as there is no sensor commercially accessible for real-time assessment of health conditions in trees. Currently, the most widely used mechanism for monitoring HLB is exploration, which is an expensive, labor-intensive, and time-consuming process. Molecular techniques such as polymerase chain reaction are used for the identification of HLB disease, which requires detailed sampling and processing procedures. Furthermore, investigations are ongoing in spectroscopic and imaging techniques, profiling of plant volatile organic compounds, and isothermal amplification. This study recognizes the need for developing a rapid, cost-effective, and reliable health-monitoring sensor that would facilitate advancements in HLB disease detection. This paper compares the benefits and limitations of these potential methods for HLB detection.

Correlation of Fine Needle Aspiration Cytology of Thyroid Gland with Histopathological Results

2018 ◽  
Vol 90 (5) ◽  
pp. 1-5 ◽  
Author(s):  
Ewa Machała ◽  
Jan Sopiński ◽  
Iulia Iavorska ◽  
Krzysztof Kołomecki
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Cost Effective ◽  
Needle Aspiration ◽  
The Other ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

ABSTRACT Fine needle aspiration cytology (FNAC) is considered as the gold standard diagnostic test for the diagnosis of thyroid nodules. It is a cost-effective procedure that provides specific diagnosis rapidly with minimal complications. It plays an important role in the determination of treatment- patients with suspected malignancy diagnosis can be subjected to surgery. On the other hand it can decrease the rate of unnecessary surgeries. Aims: The aim of this study was to evaluate and compare the correlation, accuracy of fine needle aspirational cytology (FNAC) in the diagnosis of thyroid lesions with the final histopathologic diagnosis in the surgical specimens. Materials and Methods: In our study we have performed a retrospective analysis of a case series of patients who were admitted to the Department of Endocrine, General and Oncological Surgery of Hospital of M. Kopernik in Łodź (Poland) between May 2016 and December 2017 and underwent FNAC with subsequent surgery. Cytological diagnosis was classified into six Bethesda categories. Results: On cytological examination 1070/1262 were reported as benign, 49 malignant and 143 suspicious. On histopathological examination, 956/1070 cases were confirmed as benign but there were 114 discordant cases. Among the other cases histopathology diagnosis of malignancy matched in 45/49 and 128/143 cases.The sensitivity and specificity were 60,28% and 98,05% respectively. False positive rate was 1.95% and false negative rate was 39.72%. The positive predictive value was 90.1% and negative predictive value was 89.35%. Accuracy of FNA in differentiating benign from malignant thyroid lesions was 89,46%. Conclusions: Fine needle aspiration cytology is a simple, cost-effective and popular procedure for the diagnosis of thyroid cancer. It is recommended as the first line investigation for the diagnosis of thyroid lessions.

scholarly journals Scalp Melanoma Diagnosed by Fine Needle Aspiration Cytology in a Tertiary Health Center

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
A. B. Zarami ◽  
N. A. Satumari ◽  
M. Ahmed
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Cost Effective ◽  
Skin Neoplasms ◽  
Needle Aspiration ◽  
Late Presentation ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Black Africa ◽  
Needle Aspiration Cytology

Melanoma is one of the most aggressive malignant skin neoplasms worldwide with more than 20% of world melanoma seen in black Africa and Asia. Late presentation due to ignorance, poverty, and lack of adequate health facility in Nigeria is always the norms. We present this case report because of precision in diagnosis, using fine needle aspiration cytology (FNAC) to reemphasize that the technique is cheap, cost effective, and quick that can reduce the burden of incisional biopsy before definitive surgery and improve early detection of the disease especially in developing countries.

Use of fine needle aspiration for solid breast lesions Is accurate and cost-effective

1997 ◽  
Vol 174 (6) ◽  
pp. 694-698 ◽  
Author(s):  
Mark Rubin ◽  
Kent Horiuchi ◽  
Nancy Joy ◽  
William Haun ◽  
Robert Read ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Fine Needle

scholarly journals Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Kiyohito Kato ◽  
Hideki Kamada ◽  
Takayuki Fujimori ◽  
Yuuichi Aritomo ◽  
Masahiro Ono ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Fine Needle Aspiration ◽  
Early Stage ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Diagnostic Techniques ◽  
Pancreatic Tumors ◽  
Diagnostic Modality ◽  
Fine Needle ◽  
Response To Chemotherapy

We review the utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), a rapid, safe, cost-effective, and accurate diagnostic modality for evaluating pancreatic tumors. EUS-FNA is currently used for the diagnosis and staging of pancreatic tumors. The sensitivity of EUS-FNA for pancreatic malignancy ranges from 75% to 94%, and its specificity approaches 100% in most studies. However, EUS-FNA has some limitations in the diagnosis of well-differentiated or early-stage cancers. Recent evidence suggests that molecular biological analysis using specimens obtained by EUS-FNA improves diagnostic sensitivity and specificity, especially in borderline cytological cases. It was also reported that additional information regarding patient response to chemotherapy, surgical resectability, time to metastasis, and overall survival was acquired from the genetic analysis of specimens obtained by EUS-FNA. Other studies have revealed that the analysis of KRAS, MUC, p53, p16, S100P, SMAD4, and microRNAs is helpful in making the diagnosis of pancreatic carcinoma. In this paper, we describe the present state of genetic diagnostic techniques for use with EUS-FNA samples in pancreatic diseases. We also discuss the role of molecular biological analyses for the diagnosis of pancreatic carcinoma.

Sign in / Sign up

Export Citation Format

Share Document