scholarly journals Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications

2019 ◽  
Vol 144 (1) ◽  
pp. 115-118 ◽  
Author(s):  
Shrinidhi Nathany ◽  
Vidya Monappa
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Chromosomal Abnormalities ◽  
Spindle Cell Carcinoma ◽  
Molecular Signature ◽  
Kidney Tumors ◽  
High Nuclear Grade ◽  
Spindle Cells ◽  
Prognostic Implications ◽  
Cellular Pleomorphism

Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence of necrosis. Rare cases can show aggressive growth and distant metastasis. Mucinous tubular and spindle cell carcinoma has characteristic chromosomal abnormalities and the molecular signature remains the same, irrespective of the varied histomorphology.

Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast

2015 ◽  
Vol 139 (4) ◽  
pp. 552-557 ◽  
Author(s):  
Jessica B. Dwyer ◽  
Beth Z. Clark
Keyword(s):  
Local Recurrence ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Definitive Diagnosis ◽  
Low Grade ◽  
Carcinoma Of The Breast ◽  
Complete Excision ◽  
Favorable Prognosis ◽  
Spindle Cells

Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Recognition of a proliferation of cytologically bland spindle cells with areas of epithelial differentiation in combination with immunohistochemistry using antibodies against cytokeratins and myoepithelial markers should aid in producing a definitive diagnosis. These tumors can be locally aggressive with an increased incidence of local recurrence, but the potential for lymph node or distant metastasis is low. Complete excision with adequate margins is considered curative in the majority of cases.

Chromosomal abnormalities of high-grade mucinous tubular and spindle cell carcinoma of the kidney

2017 ◽  
Vol 71 (5) ◽  
pp. 719-724 ◽  
Author(s):  
Evita T Sadimin ◽  
Ying-Bei Chen ◽  
Lu Wang ◽  
Pedram Argani ◽  
Jonathan I Epstein
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Chromosomal Abnormalities ◽  
Spindle Cell Carcinoma ◽  
High Grade

scholarly journals Mucinous tubular and spindle cell carcinoma with a high nuclear grade and micropapillary pattern: A case report

2017 ◽  
Author(s):  
Toru Sakatani ◽  
Yoshinaga Okumura ◽  
Naoto Kuroda ◽  
Toshihiro Magaribuchi ◽  
Yorika Nakano ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Nuclear Grade ◽  
High Nuclear Grade ◽  
Micropapillary Pattern

scholarly journals Sarcomatoid (Spindle Cell) Carcinoma of Tongue: A Report of Two Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Montserrat Reyes ◽  
Gina Pennacchiotti ◽  
Fabio Valdes ◽  
Rodrigo Montes ◽  
Marcelo Veloso ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
Spindle Cell Carcinoma ◽  
Histopathological Diagnosis ◽  
Spindle Cells ◽  
The Right ◽  
Conclusive Diagnosis ◽  
Carcinoma Of Tongue ◽  
Aggressive Variant

Sarcomatoid Carcinoma (SC) is an unusual and aggressive variant of squamous cell carcinoma, which frequently recurs and metastasizes; for this reason, the right diagnosis is very important. It is considered to be a biphasic tumor made up of cells from squamous and spindle cells carcinoma with a sarcomatous aspect, but of epithelial origin. The diagnosis often represents a clinical-pathological challenge where the study with immunohistochemical technique (IHC) is key to the histopathological diagnosis. The reported cases related to oral mucosa are limited. In this work we present two SC cases where the use of IHC allowed us to achieve a conclusive diagnosis.

scholarly journals Spindle Cell Carcinoma of the Oral Cavity: A Case Report of a Rare Entity and Review of Literature

2010 ◽  
Vol 1 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Nilima Prakash ◽  
MS Harish Kumar ◽  
P Sharada ◽  
GL Pradeep
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Clinical Course ◽  
Malignant Neoplasm ◽  
Spindle Cell Carcinoma ◽  
Review Of Literature ◽  
Upper Aerodigestive Tract ◽  
Cell Component ◽  
Spindle Cells ◽  
High Incidence

ABSTRACT Spindle cell carcinoma is a rare and peculiar biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. It consists of sarcomatoid proliferation of pleomorphic spindle cells and squamous cell carcinoma. It is considered potentially aggressive in its biological nature with a high incidence of metastases. We report a case of this tumor with an unusual clinical course. The histogenesis of the spindle cell component is discussed in detail in the review of literature.

scholarly journals Case of renal mucinous tubular and spindle cell carcinoma with high nuclear grade

2019 ◽  
Vol 2 (4) ◽  
pp. 193-196
Author(s):  
Tomoya Hatayama ◽  
Yohei Sekino ◽  
Hiroyuki Shikuma ◽  
Sakurako Mukai ◽  
Masayuki Muto ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Nuclear Grade ◽  
High Nuclear Grade

scholarly journals Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature

CytoJournal ◽  
2015 ◽  
Vol 12 ◽  
pp. 28 ◽  
Author(s):  
Jiang Huimiao ◽  
Julie Chepovetsky ◽  
Ming Zhou ◽  
Wei Sun ◽  
Aylin Simsir ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Spindle Cell ◽  
Case Reports ◽  
Needle Aspiration ◽  
Spindle Cell Carcinoma ◽  
World Health ◽  
Low Grade ◽  
Kidney Tumors ◽  
Fine Needle

Renal mucinous tubular and spindle cell carcinoma (MTSCC) was recently described as a distinct subtype of renal cell carcinoma (RCC) in the 2004 World Health Organization classification of kidney tumors. MTSCC is a rare low grade malignancy with < 100 cases reported in the literature. To the best of our knowledge, there are 5 case reports with a total of 6 patients describing its diagnosis by fine needle aspiration (FNA). All of these cases were diagnosed as conventional RCC on FNA. Subsequent excisions proved them to be MTSCC. We herein report a case in a 67-year-old male. He presented with abdominal pain and was found to have a new colon adenocarcinoma with metastasis to the liver and lungs. The extent of disease made the patient ineligible for surgical excision, and he received chemotherapy. Work-up also revealed a kidney mass which was later biopsied by FNA and core biopsy. The tumor was composed of epithelial and spindled cell components embedded in a myxoid background. It was positive for CK7, AMCAR, vimentin, and epithelial membrane antigen. The tumor was diagnosed as MTSCC. One year later the kidney mass remained stable. However, the patient developed new metastasis to the liver from colonic primary. The kidney mass was not resected. Although rarely encountered in FNA cytology of the kidney, we believe the cytologic features of this tumor are distinctive and are different from conventional and other subtypes of RCC. Therefore, its accurate diagnosis on FNA is possible once pathologists are aware that MTSCC should be considered in the differential diagnosis of kidney tumors.

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

A Case of Laryngeal Spindle Cell Carcinoma

2004 ◽  
Vol 55 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Koji Kudo ◽  
Tatsuya Fujiyoshi ◽  
Tetsuro Wakasugi
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma
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