scholarly journals Sarcomatoid (Spindle Cell) Carcinoma of Tongue: A Report of Two Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Montserrat Reyes ◽  
Gina Pennacchiotti ◽  
Fabio Valdes ◽  
Rodrigo Montes ◽  
Marcelo Veloso ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
Spindle Cell Carcinoma ◽  
Histopathological Diagnosis ◽  
Spindle Cells ◽  
The Right ◽  
Conclusive Diagnosis ◽  
Carcinoma Of Tongue ◽  
Aggressive Variant

Sarcomatoid Carcinoma (SC) is an unusual and aggressive variant of squamous cell carcinoma, which frequently recurs and metastasizes; for this reason, the right diagnosis is very important. It is considered to be a biphasic tumor made up of cells from squamous and spindle cells carcinoma with a sarcomatous aspect, but of epithelial origin. The diagnosis often represents a clinical-pathological challenge where the study with immunohistochemical technique (IHC) is key to the histopathological diagnosis. The reported cases related to oral mucosa are limited. In this work we present two SC cases where the use of IHC allowed us to achieve a conclusive diagnosis.

Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma

2020 ◽  
Vol 13 (4) ◽  
pp. e234779 ◽  
Author(s):  
Moyosore D Awobajo ◽  
Ara A Vaporciyan ◽  
Charles Lu ◽  
Saumil J Gandhi
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Stereotactic Body Radiation Therapy ◽  
Spindle Cell ◽  
Primary Tumour ◽  
Spindle Cell Carcinoma ◽  
Ct Guided ◽  
Stereotactic Body Radiation ◽  
Positron Emission ◽  
The Right

A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour, curative radiation with stereotactic body radiation therapy (SBRT) to the right upper lobe primary tumour was planned as patient was deemed not to be a surgical candidate. Repeat imaging with a CT chest 2 months after SBRT demonstrated good local control of the primary disease in the right upper lobe despite rapidly advancing distant metastasis. The patient continues systemic therapy with pembrolizumab, to which she has shown good response.

Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast

2015 ◽  
Vol 139 (4) ◽  
pp. 552-557 ◽  
Author(s):  
Jessica B. Dwyer ◽  
Beth Z. Clark
Keyword(s):  
Local Recurrence ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Definitive Diagnosis ◽  
Low Grade ◽  
Carcinoma Of The Breast ◽  
Complete Excision ◽  
Favorable Prognosis ◽  
Spindle Cells

Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Recognition of a proliferation of cytologically bland spindle cells with areas of epithelial differentiation in combination with immunohistochemistry using antibodies against cytokeratins and myoepithelial markers should aid in producing a definitive diagnosis. These tumors can be locally aggressive with an increased incidence of local recurrence, but the potential for lymph node or distant metastasis is low. Complete excision with adequate margins is considered curative in the majority of cases.

scholarly journals HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Katsumi Kito ◽  
Toshiharu Maeda ◽  
Keiko Ninomiya ◽  
Atsuro Sugita ◽  
Teiri Sagawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Metaplastic Carcinoma ◽  
Apocrine Carcinoma ◽  
Her2 Positive ◽  
First Case ◽  
Spindle Cell Lesion ◽  
Apocrine Differentiation ◽  
The Right

Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.

scholarly journals SPINDLE CELL CARCINOMA OF LARYNX- A DISTINCT CLINICOPATHOLOGICAL AND HISTOLOGICAL ENTITY

2017 ◽  
Vol 3 (3) ◽  
Author(s):  
Muhammad Faisal ◽  
Arif Jamshed ◽  
Raza Hussain
Keyword(s):  
Risk Factors ◽  
Cell Carcinoma ◽  
Vocal Cord ◽  
Distant Metastasis ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Treatment Result ◽  
Left Vocal Cord ◽  
History Of ◽  
The Right

Spindle cell carcinoma (SpCC) is a variant of squamous cell carcinoma with biphasic components and more aggressive behaviour. Its rarity and histopathological pattern pose a diagnostic challenge. Early diagnosis and treatment result in a decrease in local and distant metastasis. Case 1 is a 71-year-old female presented with hoarseness of voice and dyspnoea for 2 years without any risk factors. Fibre-optic laryngoscopy (FOL) revealed smooth polyp hanging from anterior two-third of the left vocal cord. Microlaryngoscopic excision revealed SpCC followed by post-operative radiotherapy and is currentlyalive. Case 2 is a 72-year-old male presented with worsening stridor for 2 years post-excision of laryngeal nodule and history of smoking and hookah use for >20 years. He developed dysphonia after a few months with fixed hard level 3 nodes at the right side. FOL showed a polypoid mass extending from the left vocal cord into the supraglottis. Fine-needle aspiration cytology of the neck swelling confirmed the diagnosis of SpCC. Computerised tomography (CT) chest/abdomen showed distant metastasis. Palliative radiotherapy was given, but the patient died after 3 months due to locoregional failure. Case 3 is a 35-year-old male presented with a history of hoarseness for 3 years with no risk factors. FOL showed a 1.2-cm polypoid growth on the right vocal cord. Total laryngectomy was performed and histopathology showed SpCC. Radiotherapy was given and the patient is alive without disease with regular follow-ups. Smoking and alcohol are thought to be the contributing factors causing this disease. Biphasic nature of the tumour requires pathological sampling for diagnostic confirmation. Surgery combined with radiotherapy has a better survival outcome. SpCC is a rare tumour with a tendency for locoregionalrecurrence. Surgery should remain the mainstay of treatment followed by post-operative radiotherapy for a better control.Key words: Larynx, radiotherapy, spindle cell carcinoma

Spindle Cell Carcinoma of Oral Cavity: A Rare Entity

2021 ◽  
Vol 20 (4) ◽  
pp. 923-925
Author(s):  
Ng CS ◽  
Mohd Razif M Y ◽  
Chew MX ◽  
Suria HMP
Keyword(s):  
Cell Carcinoma ◽  
Tooth Extraction ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
Medical Science ◽  
Spindle Cell Carcinoma ◽  
Tumour Bulk ◽  
The Right ◽  
8Th Edition

Introduction:Spindle cell carcinomas (SpCC) are a rare variant of squamous cell carcinoma which is rarely encountered in the head and neck. It is also known as“pseudocarcinoma”, “sarcomatoidcarcinoma,” and “carcinosarcoma”.It has an aggressive nature and has poor prognosis despite aggressive treatment. Case report: A 48-year-old lady presented to us with a right painless upper gum swelling which was progressively enlarging for 3 months after tooth extraction. Examination of the oral a fungating mass over the right upper alveolus extending to the right upper gingivolabial sulcus. She was subjected to a debulking palliative to reduce the tumour bulk. The intraoperative samples sent for histopathological examination was reported as SpCC, AJCC (8th edition) stage pT2pN3b. She recovered well after the surgery with quality of life after the surgery. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.923-925

scholarly journals A Case Report of Spindle Cell (Sarcomatoid) Carcinoma of the Larynx

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Harry Boamah ◽  
Billy Ballard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Early Stage ◽  
Sarcomatoid Carcinoma ◽  
Good Control ◽  
Spindle Cell Carcinoma ◽  
Good Prognosis

Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often detected at an early stage, removed by polypectomy during diagnosis, and tend to have a very good prognosis. We present a case of spindle cell carcinoma in a 67-year-old Caucasian male who presented with progressive hoarseness of his voice, dysphagia, odynophagia and a 20-pound weight loss. The patient underwent direct laryngoscopy with excision of the malignant mass and received radiation therapy. His symptoms gradually improved, and he regained good control of his voice.

Right Maxillary Sinus Sarcomatoid Carcinoma (Sarcomatoid/Spindle Cell Carcinoma)

2007 ◽  
Vol 137 (2) ◽  
pp. 355-357 ◽  
Author(s):  
Scott N. Howard ◽  
William R. Bond ◽  
In Soon Hong ◽  
Robert D. Foss
Keyword(s):  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
Spindle Cell Carcinoma

scholarly journals Surgical resection of a rapidly growing pulmonary spindle cell carcinoma by robot-assisted thoracoscopic surgery: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Akihiro Koen ◽  
Hideyuki Maeda ◽  
Yoji Nagashima ◽  
Masato Kanzaki
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Spindle Cell ◽  
Thoracoscopic Surgery ◽  
Spindle Cell Carcinoma ◽  
Robot Assisted ◽  
Case Presentation ◽  
Abnormal Shadow ◽  
The Right

Abstract Background Pulmonary spindle cell carcinoma (PSCC) is an extremely rare tumor that is highly malignant and fast-growing. As chemotherapy and radiation therapy are ineffective, early surgical resection is effective for PSCC. Case presentation A 70-year-old woman with rheumatoid arthritis was referred to our hospital with an abnormal shadow. Chest computed tomography revealed a 33-mm-wide lobular mass in the right upper lobe. She was diagnosed with non-small cell lung cancer by bronchoscopic smear cytology. Although staging evaluation indicated stage IIIB (T3N2M0) disease, she required continued administration of immunosuppressants and prednisolone for rheumatoid arthritis. Therefore, robot-assisted thoracoscopic surgery (RATS) right upper lobectomy followed by lymph node dissection was performed without preoperative chemotherapy and radiotherapy. Pathological findings revealed PSCC. Conclusions We report a very rare case of pulmonary spindle cell carcinoma, successfully resected with RATS.

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