scholarly journals Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

2018 ◽  
Vol 143 (7) ◽  
pp. 821-831 ◽  
Author(s):  
May P. Chan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Correct Diagnosis ◽  
Condyloma Acuminatum ◽  
Diagnostic Challenge ◽  
Bowenoid Papulosis ◽  
Verruciform Xanthoma ◽  
Anogenital Area

Context.—Histologic distinction between condyloma acuminatum and various benign and malignant condyloma-like lesions in the anogenital area poses a common diagnostic challenge to pathologists across subspecialties.Objective.—To review the overlapping and distinguishing features of condyloma acuminatum and its mimics, and to clarify confusing terminology and diagnostic criteria for problematic entities.Data Sources.—A review of the literature on condyloma acuminatum (ordinary and giant types), verrucous carcinoma, warty/warty-basaloid high-grade squamous intraepithelial lesion and squamous cell carcinoma, papillary squamous cell carcinoma, bowenoid papulosis, verruca vulgaris, epidermolytic acanthoma, and verruciform xanthoma was performed.Conclusions.—Correct diagnosis of condyloma acuminatum and condyloma-like lesions has important clinical implication and entails familiarization with their clinical presentations and histopathologic features. Contrary to historical belief, giant condyloma acuminatum and verrucous carcinoma should be considered distinct entities based on different pathogenetic pathways. Ancillary tools available for identifying and genotyping human papillomavirus can aid in diagnosis when histopathologic findings are inconclusive. Recognition of relatively rare entities such as bowenoid papulosis, epidermolytic acanthoma, and verruciform xanthoma would avoid overdiagnosis and unnecessary, overaggressive treatment.

A Case of Verrucous Carcinoma (Epithelioma Cuniculatum) of the Heel Mimicking Infected Epidermal Cyst and Gout

2008 ◽  
Vol 1 (5) ◽  
pp. 297-299 ◽  
Author(s):  
Mahbod Arefi ◽  
Elizabeth Philipone ◽  
Russell Caprioli ◽  
John Haight ◽  
Hugh Richardson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Rare Variant ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Epidermal Cyst ◽  
Diagnostic Challenge ◽  
Epithelioma Cuniculatum ◽  
Well Differentiated

Verrucous carcinoma is a rare variant of well-differentiated squamous cell carcinoma. It usually occurs in the oral cavity, genital area, and sole. Verrucous carcinoma of the sole, also called epithelioma cuniculatum, often presents a diagnostic challenge both clinically and histopathologically. The authors report such a case that mimics infected epidermal cyst and gout clinically

Oral Cancer: Raising Awareness of the Importance of Suspicion in Early Detection

2021 ◽  
Vol 10 (1) ◽  
pp. 10-12
Author(s):  
Farooq Ahmed ◽  
Honieh Bolooki ◽  
Senathrajah Ariyaratnam ◽  
Michael N. Pemberton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma ◽  
Mucosal Lesion ◽  
Morbidity And Mortality ◽  
Raising Awareness ◽  
Suspicious Lesions

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. The second patient presented with a hyperplastic mucosal lesion, suspected as forming due to denture-clasp irritation, which was subsequently diagnosed as proliferative verrucous carcinoma. The importance of early detection and palpation of suspicious lesions is emphasised in this article.

Squamous-cell carcinoma of the pelvis in a giant condyloma acuminatum

1998 ◽  
Vol 41 (11) ◽  
pp. 1450-1453 ◽  
Author(s):  
Micheline Hyacinthe ◽  
Richard Karl ◽  
Domenico Coppola ◽  
Thomas Goodgame ◽  
William Redwood ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Condyloma Acuminatum ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum

VERRUCOUS CARCINOMA AS A CLINICOPATHOLOGIC VARIANT OF SQUAMOUS CELL CARCINOMA

2017 ◽  
Vol 124 (2) ◽  
pp. e80
Author(s):  
ALOIZIO PREMOLI MACIEL ◽  
VICTOR TIEGHI-NETO ◽  
CARLA RENATA SANOMIYA IKUTA ◽  
LUIZ ANTONIO DE ASSIS TAVEIRA ◽  
JOSÉ BURGOS PONCE ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Verrucous Carcinoma

scholarly journals Hypertrophic Lichen Planus versus Well-Differentiated Squamous Cell Carcinoma: A Histological Challenge 

2017 ◽  
Vol 1 (2) ◽  
pp. 91
Author(s):  
Samuel P Haslam ◽  
Lindy S Ross ◽  
Alison C Lowe ◽  
Brent C Kelly
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Multiplex Pcr ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Correct Diagnosis ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Lichen Simplex Chronicus ◽  
Well Differentiated

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP. 

scholarly journals Squamous cell carcinoma mimicking a wart

2021 ◽  
Vol 12 (4) ◽  
pp. 471-472
Author(s):  
Aida Oulehri ◽  
Sara Elloudi ◽  
Hanane Baybay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Soft Tissues ◽  
Verrucous Carcinoma ◽  
Previous History ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Complete Surgical Excision ◽  
Safety Margins

Sir, Cutaneous squamous cell carcinoma, a malignant proliferation of the cutaneous epithelium, represents the second most common non-melanoma skin cancer after basal cell carcinoma [1]. Verrucous carcinoma (VC) is a rare, low-grade, well-differentiated squamous cell carcinoma most commonly seen in the mucosa, infrequently reported to occur in the skin, where it is a slow-growing and locally aggressive tumor. It is not uncommon for cutaneous verrucous carcinomas to be mistaken for the more frequent wart (verruca vulgaris) and treated accordingly [2]. The etiopathogenesis of VC is not completely known. One theory mentions the human papillomavirus (HPV) infection; with plantar lesions, the types involved are reported to be 16 and 11 [3]. Histopathological diagnosis is difficult and needs one or more broad and in-depth biopsies. Morbidity results from the local destruction of the skin and soft tissues and, occasionally, from a perineural, muscular, and even bony invasion. Metastasis to regional lymphatic ganglia is rare, found in 5% of cases [4]. VC bears a high risk of local relapse. No matter the treatment employed, the rate of recurrence varies from 30% to 50% and usually is not the result of incomplete surgical interventions. The treatment of choice is complete surgical excision with safety margins [5]. A forty-year-old female patient with no previous history presented herself with a hyperkeratotic lesion on the right foot persistent for two years, which she had been manipulating routinely, which had progressively been increasing in size for the previous year, and which, for the previous three months, had become painful and bleeding. An examination revealed a hyperkeratotic plaque with a hyperpigmented border, hard on palpation, adherent to the deep plane, and with an eroded surface (Fig. 1). Dermoscopy was able to find a papillomatous appearance surrounded by dotted vessels (Fig. 2). This dermoscopic aspect typical of vulgar warts was confusing. Indeed, dermoscopy of the foot wart shows red or black dots in the center of papillomatous structures, which are thrombosed vessels supplying the wart; hence the importance, in our opinion, of the clinical and pathological correlation. For this reason, we performed a skin biopsy; an anatomopathological study found a squamous cell carcinoma of the verrucous type.

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