scholarly journals Tumor Budding in Colorectal Carcinoma: Translating a Morphologic Score Into Clinically Meaningful Results

2018 ◽  
Vol 142 (8) ◽  
pp. 952-957 ◽  
Author(s):  
Soo-Jin Cho ◽  
Sanjay Kakar
Keyword(s):  
Prognostic Factor ◽  
Colorectal Carcinoma ◽  
English Language ◽  
Lymph Node Involvement ◽  
Consensus Conference ◽  
Tumor Budding ◽  
Independent Prognostic Marker ◽  
Routine Basis ◽  
Node Involvement ◽  
Pathology Reports

Context.— Tumor budding has received increasing recognition as an important independent prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma arising in a polyp has been shown to be a risk factor for lymph node involvement. The variability in methods used for evaluating tumor budding in different studies and lack of standardized guidelines have impeded routine inclusion of tumor budding in pathology reports. This changed last year with consensus guidelines based on the International Tumor Budding Consensus Conference (ITBCC). These guidelines have been included in the recent College of American Pathologists (CAPs) Colorectal Cancer Protocol. The consensus methodology will allow uniform reporting of this finding, but challenges in interpretation in the setting of intense inflammation, fibrosis, or gland fragmentation need to be addressed in future guidelines. Objective.— To provide a brief overview of the known clinical significance of tumor budding in colorectal carcinoma and discuss the practical aspects of its implementation on a routine basis. Data Sources.— English-language pathology literature. Conclusions.— Tumor budding has been shown to be an independent prognostic marker in colorectal carcinomas and the routine reporting of tumor buds is now advocated by using the approach outlined by the ITBCC guidelines. Tumor budding is included in the CAP protocol as a recommended element. Presence of prominent tumor budding in an adenocarcinoma in a polyp may have implications for management, such as additional resection, while it serves as a prognostic factor in other settings.

Histology as a Prognostic Factor in Early Gastric Cancer

1992 ◽  
Vol 78 (3) ◽  
pp. 181-184
Author(s):  
Massimo Ferrari ◽  
Enrico Ghislandi ◽  
Giuseppe Landonio ◽  
Margherita Majno ◽  
Tiziano Porretta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Early Gastric Cancer ◽  
Lymph Node Involvement ◽  
Depth Of Invasion ◽  
Undifferentiated Histology ◽  
Node Involvement

Of 431 patients with gastric cancer observed in our Istitution, 23 (5.3 %) had early gastric cancer (EGC). Macroscopic presentation, histology, depth of invasion, and lymph node involvement were evaluated in all the cases. All patients underwent surgery and an intensive follow-up was performed. Five of the 23 patients progressed, and the risk factors were examined. Histology seemed to be the main prognostic factor in our study, since intestinal type of EGC was associated to a significantly better prognosis. Total gastrectomy is indicated in the proximal localization of EGC, and should perhaps be performed also in cases presenting undifferentiated histology.

Optimizing cut-offs for high neutrophil-to-lymphocyte ratio as poor survival prognostic factor in colorectal cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15111-e15111
Author(s):  
Fernando Namuche ◽  
Jorge Leon ◽  
Paola Catherine Montenegro ◽  
Claudio J. Flores
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Cox Regression ◽  
Locally Advanced ◽  
Lymph Node Involvement ◽  
Histologic Grade ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Node Involvement

e15111 Background: The incidence of colorectal cancer (CRC) in Peru has increased in the last decades. Needing to use all the possible tools for an accurate diagnosis and early treatment. Neutrophil-to-lymphocyte ratio (NLR) has been associated as poor prognostic factor in OS and PFS in CRC. There is no data that support this statement in Latin America. It is of a special utility in our country the detection of a simple and reproducible prognostic biomarker that guides the use of more advanced tests. Our objective was to explore the factors associated with OS in the local-locally advanced and metastatic settings. Methods: We retrospectively reviewed the electronic medical records of 609 patients with CRC from one specialized Peruvian cancer center between 2006 and 2016 Descriptive results for numeric variables were presented as means with standard deviation (SD) or medians with interquartile range (IQR), depending on their distributions; otherwise, we expressed the qualitative variables as numbers with percentages. We divided our population into two groups: Local-locally advanced (L-LA) (516 pts) and debut metastatic- recurrence (M-R) (108 pts). We performed a ROC curve analysis to determine an appropriate cut-off value for NLR in both groups (L-LA:NLR ≥3, M-R:NLR ≥5). A univariate survival analysis was performed with Kaplan Meier method, comparing the curves with Log Rank test. A multivariate analysis was performed using the Cox regression model with the statistically significant variables found in the univariate analysis. Results: Pts with high NLR had significantly shorter OS in L-LA [HR, 12.1; 95% CI,5.019-29.211; p < 0.001] M-R [HR, 5.382; 95% CI,2.835-10.217; p < 0.001] than pts with low NLR. In the multivariate model, NLR retained a significant association with OS in both groups. Cox regression demonstrated that in L-LA setting sex, histologic grade and lymph node involvement; and in M-R setting sidedness, histologic grade, LVI and metastasectomy performed were independently risk factors for a shorter OS. Conclusions: High NLR is associated with poor prognosis (with our cut-offs L-LA:NLR ≥3, M-R:NLR ≥5). There are other variables to be considered that affect the OS, as: sex, histologic grade and lymph node involvement, sidedness, histologic grade, LVI and metastasectomy performed.

Silicone lymphadenopathy: an unexpected cause of neck lumps

2012 ◽  
Vol 126 (9) ◽  
pp. 970-973 ◽  
Author(s):  
E Omakobia ◽  
G Porter ◽  
S Armstrong ◽  
K Denton
Keyword(s):  
Lymph Nodes ◽  
Breast Augmentation ◽  
English Language ◽  
Breast Implant ◽  
Excisional Biopsy ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Supraclavicular Lymph Nodes ◽  
Node Involvement ◽  
Needle Aspiration Cytology

AbstractObjective:To report a rare case of silicone lymphadenopathy solely affecting the left supraclavicular lymph nodes.Case report:Our patient presented with a painless swelling in the left supraclavicular region. Notably, she had previously undergone cosmetic breast augmentation using silicone-containing implants. Radiological imaging and subsequent excisional biopsy of the swelling produced findings consistent with a silicone foreign body reaction secondary to bilateral breast implant rupture.Conclusion:Silicone lymphadenopathy following breast augmentation primarily affects the axillary nodes. Supraclavicular lymph node involvement is unusual. To our knowledge, this is the first report in the English language literature of silicone lymphadenopathy manifesting solely in the supraclavicular lymph nodes. Although the need to exclude malignancy in such cases is of the utmost importance, silicone lymphadenopathy should also be considered in the differential diagnosis. Fine needle aspiration cytology is a useful initial investigation, which may be followed up by excisional biopsy and histological analysis for further confirmatory diagnostic information.

scholarly journals Systemic Immune-Inflammation Index Is a Prognostic Factor for Breast Cancer Patients After Curative Resection

2021 ◽  
Vol 11 ◽  
Author(s):  
Wen Li ◽  
Guangzhi Ma ◽  
Yunfu Deng ◽  
Wenjie Chen ◽  
Zhenkun Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Histological Grade ◽  
Lymph Node Involvement ◽  
Breast Cancer Patients ◽  
Optimal Cutoff ◽  
Cutoff Value ◽  
Post Surgery ◽  
Node Involvement

BackgroundThe preoperative systemic immune-inflammation index (SII) is correlated with prognosis in several malignancies. The aim of this study was to investigate the prognosis value of SII in patients with resected breast cancer.Materials and MethodsA total of 784 breast cancer patients who underwent surgical resection were consecutively investigated. The optimal cutoff value of SII was evaluated using the receiver operating characteristic (ROC) curve. The collection of SII with clinicopathological characteristic and prognosis was further evaluated.ResultsThe optimal cutoff value for SII in the prediction of survival was 514 according to ROC curve analysis. A high SII was significantly correlated with younger age (P = 0.037), PR status (P &lt; 0.001), and HER2 status (P = 0.035). Univariate analysis revealed that SII (P &lt; 0.001), T-stage (P &lt; 0.001), lymph node involvement post-surgery (P = 0.024), and histological grade (P &lt; 0.001) were significantly related to DFS, and SII (P &lt; 0.001), T-stage (P = 0.003), lymph node involvement post-surgery (P = 0.006), and histological grade (P &lt; 0.001) were significantly associated with OS. In multivariate analysis, a high SII was an independent worse prognostic factor for DFS (HR, 4.530; 95% CI, 3.279-6.258; P &lt; 0.001) and OS (HR, 3.825; 95% CI, 2.594-5.640; P &lt; 0.001) in all the enrolled patients. Furthermore, subgroup analysis of molecular subtype revealed that SII was significantly associated with prognosis in all subtypes.ConclusionPreoperative SII is a simple and useful prognostic factor for predicting long-term outcomes for breast cancer patients undergoing surgery.

EP468 Tumor size as prognostic factor of lymph node involvement in endometrial cancer

2019 ◽  
Author(s):  
D Al-Dali ◽  
M Pérez de Puig ◽  
C López ◽  
M Fernández ◽  
G Salinas ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Tumor Size ◽  
Lymph Node Involvement ◽  
Node Involvement
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