scholarly journals Characterization of the Clinical Outcomes With Cefepime in a Neonatal Intensive Care Unit: A Retrospective Cohort Study

2018 ◽  
Vol 23 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Chad A. Knoderer ◽  
David M. Kaylor ◽  
Meghan E. Toth ◽  
Katherine M. Malloy ◽  
Kristen R. Nichols
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Clinical Response ◽  
Clinical Outcomes ◽  
Neonatal Intensive Care ◽  
Final Analysis ◽  
Primary Outcome Measure ◽  
Postmenstrual Age

OBJECTIVES The objective of this study was to characterize clinical outcomes when cefepime was used in a neonatal intensive care population. METHODS Data were extracted from the medical records of all full-term (40 weeks gestational age) patients up to 2 months of age and preterm patients up to 48 weeks postmenstrual age admitted to the neonatal intensive care unit (NICU) at a freestanding children's hospital between January 1, 2010, and December 31, 2013, who received at least 48 hours of cefepime. The primary outcome measure was a positive clinical response as defined by a normalization of white blood cell count and/or culture clearance. RESULTS Final analysis included 74 patients. Clinical response was evaluable in 43.2% (32 of 74) of courses. Of these, positive clinical response was observed in 81.3% (26 of 32). Overall patient mortality was 16.2% (12 of 74). Adverse effects (AEs) occurred in 14.9% (11 of 74) of courses. CONCLUSIONS Cefepime can be used safely with reasonable clinical response in a NICU population, but additional studies are needed to further determine cefepime-associated clinical outcomes.

scholarly journals Beginning to See the Light: Lessons Learned From the Development of the Circadian System for Optimizing Light Conditions in the Neonatal Intensive Care Unit

2021 ◽  
Vol 15 ◽  
Author(s):  
Esther M. Hazelhoff ◽  
Jeroen Dudink ◽  
Johanna H. Meijer ◽  
Laura Kervezee
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Clinical Outcomes ◽  
Neonatal Intensive Care ◽  
Circadian System ◽  
Lessons Learned ◽  
Preterm Neonates ◽  
Negative Effects ◽  
Beneficial Effects

The circadian timing system optimizes health by temporally coordinating behavior and physiology. During mammalian gestation, fetal circadian rhythms are synchronized by the daily fluctuations in maternal body temperature, hormones and nutrients. Circadian disruption during pregnancy is associated with negative effects on developmental outcomes in the offspring, highlighting the importance of regular and robust 24-h rhythms over gestation. In the case of preterm birth (before 37 weeks of gestation), maternal cues no longer synchronize the neonate’s circadian system, which may adversely affect the neonate. There is increasing evidence that introducing robust light-dark cycles in the Neonatal Intensive Care Unit has beneficial effects on clinical outcomes in preterm infants, such as weight gain and hospitalization time, compared to infants exposed to constant light or constant near-darkness. However, the biological basis for these effects and the relationship with the functional and anatomical development of the circadian system is not fully understood. In this review, we provide a concise overview of the effects of light-dark cycles on clinical outcomes of preterm neonates in the NICU and its alignment with the development of the circadian system.

scholarly journals Characterization of acoustic noise in a neonatal intensive care unit MRI system

2014 ◽  
Vol 44 (8) ◽  
pp. 1011-1019 ◽  
Author(s):  
Jean A. Tkach ◽  
Yu Li ◽  
Ronald G. Pratt ◽  
Kelly A. Baroch ◽  
Wolfgang Loew ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Acoustic Noise
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