scholarly journals Systematic literature review and evaluation of health technologies in ovarian cancer to develop clinical practice guidelines

Medwave ◽  
2014 ◽  
Vol 14 (S.1) ◽  
pp. e5757-e5757
Author(s):  
Marcela Pezzani ◽  
Gabriela Moreno ◽  
Bibiana Acebedo
Keyword(s):  
Ovarian Cancer ◽  
Clinical Practice ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Health Technologies

PASI 100 response rates in moderate to severe psoriasis: a systematic literature review and analysis of clinical practice guidelines

2021 ◽  
pp. 1-9
Author(s):  
Isabel Belinchón Romero ◽  
Esteban Dauden ◽  
Carlos Ferrándiz Foraster ◽  
Álvaro González-Cantero ◽  
Jose Manuel Carrascosa Carrillo ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Response Rates ◽  
Severe Psoriasis

scholarly journals The Italian Society of Rheumatology clinical practice guidelines for the management of polymyalgia rheumatica

Reumatismo ◽  
2020 ◽  
Vol 72 (1) ◽  
pp. 1-15
Author(s):  
N. Ughi ◽  
G.D. Sebastiani ◽  
R. Gerli ◽  
C. Salvarani ◽  
S. Parisi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Polymyalgia Rheumatica ◽  
Working Group ◽  
Grey Literature ◽  
Italian Society ◽  
Evidence Based

Objective: to provide evidence-based up-to-date recommendations for the management of patients with a definite diagnosis of polymyalgia rheumatica (PMR). Methods: A systematic literature review was performed to find the existing clinical practice guidelines (CPGs) on PMR and the framework of the Guidelines International Network Adaptation Working Group was used to appraise (AGREE II), synthesize, and customize the recommendations according to the needs of the Italian healthcare context. Rheumatologists on behalf of the Italian Society of Rheumatology (SIR) and from the SIR Epidemiology Unit joined the working group and identified the key health questions on PMR to guide the systematic literature review. Physicians, including general practitioners and specialists, and health professionals who manage PMR in the clinical practice were the target audience. The final recommendations were rated externally by a multi-disciplinary and multi-professional group of stakeholders. Results: From the systematic search in databases (Medline, Embase) and grey literature, 3 CPGs were identified and appraised by two independent raters. Combining the statements and the evidence from these CPGs, 9 recommendations were developed by endorsement or adaptation in response to the initial key health questions. The quality of evidence was graded and the working group discussed the final recommendations in view of their implementation in the Italian healthcare context. Conclusions: In absence of national guidelines so far, these recommendations are the first to provide guidance for the management of patients with a diagnosis of PMR in Italy and they are expected to ensure the best evidence-based clinical practice for this disease.

scholarly journals Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care

2020 ◽  
Vol 30 (11) ◽  
pp. 1748-1756
Author(s):  
Charles H Norell ◽  
John Butler ◽  
Rhonda Farrell ◽  
Alon Altman ◽  
James Bentley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Practice ◽  
Health System ◽  
Cancer Treatment ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Patterns Of Care ◽  
Debulking Surgery ◽  
Potential Health ◽  
International Differences

IntroductionThe International Cancer Benchmarking Partnership demonstrated international differences in ovarian cancer survival, particularly for women aged 65–74 with advanced disease. These findings suggest differences in treatment could be contributing to survival disparities.ObjectiveTo compare clinical practice guidelines and patterns of care across seven high-income countries.MethodsA comparison of guidelines was performed and validated by a clinical working group. To explore clinical practice, a patterns of care survey was developed. A questionnaire regarding management and potential health system-related barriers to providing treatment was emailed to gynecological specialists. Guideline and survey results were crudely compared with 3-year survival by ‘distant’ stage using Spearman’s rho.ResultsTwenty-seven guidelines were compared, and 119 clinicians completed the survey. Guideline-related measures varied between countries but did not correlate with survival internationally. Guidelines were consistent for surgical recommendations of either primary debulking surgery or neoadjuvant chemotherapy followed by interval debulking surgery with the aim of complete cytoreduction. Reported patterns of surgical care varied internationally, including for rates of primary versus interval debulking, extensive/‘ultra-radical’ surgery, and perceived barriers to optimal cytoreduction. Comparison showed that willingness to undertake extensive surgery correlated with survival across countries (rs=0.94, p=0.017). For systemic/radiation therapies, guideline differences were more pronounced, particularly for bevacizumab and PARP (poly (ADP-ribose) polymerase) inhibitors. Reported health system-related barriers also varied internationally and included a lack of adequate hospital staffing and treatment monitoring via local and national audits.DiscussionFindings suggest international variations in ovarian cancer treatment. Characteristics relating to countries with higher stage-specific survival included higher reported rates of primary surgery; willingness to undertake extensive/ultra-radical procedures; greater access to high-cost drugs; and auditing.

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