scholarly journals Expression, purification and testing of zinc metalloproteinase aureolysin as potential vaccine candidate against Staphylococcus aureus

2021 ◽  
Vol 20 (2) ◽  
pp. 77-84
Author(s):  
Solyman Samar ◽  
Reda Mohamed ◽  
Hanora Amro
Keyword(s):  
Staphylococcus Aureus ◽  
Vaccine Candidate ◽  
Potential Vaccine Candidate ◽  
Potential Vaccine

Improvement of the attenuated mutant strain of Brucella melitensis Rev1 as a potential vaccine candidate

Biologia ◽  
2021 ◽  
Author(s):  
Elham Mehdizadeh Marzenaki ◽  
Ali Reza Saeedinia ◽  
Mehdi Zeinoddini ◽  
Ali Asghar Deldar
Keyword(s):  
Mutant Strain ◽  
Vaccine Candidate ◽  
Brucella Melitensis ◽  
Potential Vaccine Candidate ◽  
Potential Vaccine

scholarly journals Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate

2005 ◽  
Vol 73 (11) ◽  
pp. 7569-7577 ◽  
Author(s):  
Daxin Peng ◽  
Wenzhou Hong ◽  
Biswa P. Choudhury ◽  
Russell W. Carlson ◽  
Xin-Xing Gu
Keyword(s):  
Moraxella Catarrhalis ◽  
Lipid A ◽  
Vaccine Candidate ◽  
Gene Encoding ◽  
Potential Vaccine Candidate ◽  
Whole Cells ◽  
Potential Vaccine ◽  
Major Surface ◽  
Membrane Components ◽  
Human Infections

ABSTRACT Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of the bacterium. An lpxA gene encoding UDP-N-acetylglucosamine acyltransferase responsible for the first step of lipid A biosynthesis was identified by the construction and characterization of an isogenic M. catarrhalis lpxA mutant in strain O35E. The resulting mutant was viable despite the complete loss of LOS. The mutant strain showed significantly decreased toxicity by the Limulus amebocyte lysate assay, reduced resistance to normal human serum, reduced adherence to human epithelial cells, and enhanced clearance in lungs and nasopharynx in a mouse aerosol challenge model. Importantly, the mutant elicited high levels of antibodies with bactericidal activity and provided protection against a challenge with the wild-type strain. These data suggest that the null LOS mutant is attenuated and may be a potential vaccine candidate against M. catarrhalis.

scholarly journals Large Extracellular Loop of Tetraspanin as a Potential Vaccine Candidate for Filariasis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77394 ◽  
Author(s):  
Gajalakshmi Dakshinamoorthy ◽  
Gnanasekar Munirathinam ◽  
Kristen Stoicescu ◽  
Maryada Venkatarami Reddy ◽  
Ramaswamy Kalyanasundaram
Keyword(s):  
Vaccine Candidate ◽  
Extracellular Loop ◽  
Potential Vaccine Candidate ◽  
Large Extracellular Loop ◽  
Potential Vaccine

Immunogenicity and protection-inducing ability of recombinant Plasmodium vivax rhoptry-associated protein 2 in Aotus monkeys: A potential vaccine candidate

Vaccine ◽  
2009 ◽  
Vol 27 (21) ◽  
pp. 2870-2876 ◽  
Author(s):  
Jose Rojas-Caraballo ◽  
Alvaro Mongui ◽  
Manuel A. Giraldo ◽  
Gabriela Delgado ◽  
Diana Granados ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Vaccine Candidate ◽  
Potential Vaccine Candidate ◽  
Potential Vaccine
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