Agreement between estimated date of delivery determined by last menstrual period and ultrasound: A prospective cohort of Tanzanian women

Abstract Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting. Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation. Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface. Trial registration NCT01577147

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The onset of nausea and vomiting of pregnancy: a prospective cohort study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-020-03478-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Roger Gadsby ◽

Diana Ivanova ◽

Emma Trevelyan ◽

Jane L. Hutton ◽

Sarah Johnson

Keyword(s):

Prospective Cohort ◽

Outcome Measure ◽

Human Chorionic Gonadotrophin ◽

Menstrual Period ◽

Nausea And Vomiting ◽

Last Menstrual Period ◽

Daily Diaries ◽

The United Kingdom ◽

Almost All ◽

Time To Onset

Abstract Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting. Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation. Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface. Trial registration NCT01577147. Date of registration 13 April 2012

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Randomized trial of mifepristone and buccal or vaginal misoprostol for abortion through 56 days of last menstrual period

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70169-3 ◽

2007 ◽

Vol 2007 ◽

pp. 235-236

Author(s):

L.P. Shulman

Keyword(s):

Randomized Trial ◽

Menstrual Period ◽

Last Menstrual Period ◽

Vaginal Misoprostol

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Fetal infection resulting from maternal rubella after the first trimester of pregnancy

Journal of Hygiene ◽

10.1017/s0022172400063452 ◽

1980 ◽

Vol 85 (3) ◽

pp. 381-391 ◽

Cited By ~ 26

Author(s):

J. E. Cradock-Watson ◽

Margaret K. S. Ridehalgh ◽

Mary J. Anderson ◽

J. R. Pattison ◽

H. O. Kangro

Keyword(s):

First Trimester ◽

Menstrual Period ◽

Last Menstrual Period ◽

Igg Antibody ◽

True Rate ◽

Igm Antibody ◽

Prenatal Infection ◽

Fetal Infection ◽

First Trimester Of Pregnancy ◽

Specific Igg

SUMMARYWe have tried to measure the incidence of prenatal infection in 304 infants whose mothers had had rubella at various times after the first 12 weeks of pregnancy. Two methods of assessment were used: first, serum obtained soon after birth was tested for specific IgM antibody; secondly, serum obtained after the age of eight months was tested for specific IgG. When maternal rubella occurred 12–16 weeks after the last menstrual period specific IgM antibody was detected in 28 out of 50 infants (56%). The proportion fell progressively to 12% after maternal rubella at 24–28 weeks, rose to 19% after rubella at 28–36 weeks and then to 58% when the illness occurred during the last month of pregnancy. In all, IgM antibody was detected in 77 out of 260 infants (29%). The fetus can thus be infected at any time during the second and third trimesters of pregnancy, but the risk varies at different stages.The figures for the prevalence of IgG antibody were greater throughout, because some infants had IgG who had previously lacked specific IgM. After maternal rubella at 12–16 weeks IgG antibody persisted in 22 out of 31 infants (71%). The proportion fell to 28% after rubella at 24–28 weeks and then increased progressively to 94% after rubella during the last month. In all, IgG antibody persisted in 94 out of 190 infants (49%). The true rate of fetal infection probably lies between the rates estimated from the presence of IgM antibody and the subsequent prevalence of IgG.Infants whose mothers had rubella at any time during pregnancy should be examined regularly for possible evidence of damage.

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Validity of pre and post-term birth rates based on the date of last menstrual period compared to early obstetric ultrasonography

Cadernos de Saúde Pública ◽

10.1590/0102-311x00121514 ◽

2015 ◽

Vol 31 (4) ◽

pp. 885-890 ◽

Cited By ~ 2

Author(s):

Maria Nilza Lima Medeiros ◽

Nádia Carenina Nunes Cavalcante ◽

Fabrício José Alencar Mesquita ◽

Rosângela Lucena Fernandes Batista ◽

Vanda Maria Ferreira Simões ◽

...

Keyword(s):

Preterm Birth ◽

Positive Predictive Value ◽

Predictive Value ◽

Birth Rate ◽

Menstrual Period ◽

Last Menstrual Period ◽

Birth Rates ◽

Term Birth ◽

Preterm Birth Rate ◽

Obstetric Ultrasonography

The aim of this study was to assess the validity of the last menstrual period (LMP) estimate in determining pre and post-term birth rates, in a prenatal cohort from two Brazilian cities, São Luís and Ribeirão Preto. Pregnant women with a single fetus and less than 20 weeks' gestation by obstetric ultrasonography who received prenatal care in 2010 and 2011 were included. The LMP was obtained on two occasions (at 22-25 weeks gestation and after birth). The sensitivity of LMP obtained prenatally to estimate the preterm birth rate was 65.6% in São Luís and 78.7% in Ribeirão Preto and the positive predictive value was 57.3% in São Luís and 73.3% in Ribeirão Preto. LMP errors in identifying preterm birth were lower in the more developed city, Ribeirão Preto. The sensitivity and positive predictive value of LMP for the estimate of the post-term birth rate was very low and tended to overestimate it. LMP can be used with some errors to identify the preterm birth rate when obstetric ultrasonography is not available, but is not suitable for predicting post-term birth.

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