scholarly journals Antidiabetic effect of aqueous extract of ripe Carica papaya Linnaeus seed in alloxan-induced diabetic albino rats

2019 ◽  
Vol 10 (2) ◽  
pp. 13-17 ◽  
Author(s):  
Abimbola Morolahun Ebenezer ◽  
Omobolanle Ajao Folasade ◽  
Kali Pemba Senga
Keyword(s):  
Aqueous Extract ◽  
Carica Papaya ◽  
Albino Rats ◽  
Antidiabetic Effect

scholarly journals Antidiabetic effect of aqueous extract of Basella alba leaves and metformin in alloxan-induced diabetic albino rats

2014 ◽  
Vol 13 (24) ◽  
pp. 2455-2458 ◽  
Author(s):  
O. Bamidele, ◽  
D. S. Arokoyo, ◽  
A. M. Akinnuga, ◽  
A. O. Oluwarole,
Keyword(s):  
Aqueous Extract ◽  
Albino Rats ◽  
Antidiabetic Effect ◽  
Basella Alba

scholarly journals PHYTOCHEMISTRY, TOXICITY AND EFFICACY OF CRUDE AQUEOUS EXTRACT OF CARICA PAPAYA LEAF AGAINST TRYPANOSOMA BRUCEI

2016 ◽  
Vol 14 (1) ◽  
pp. 99-102
Author(s):  
A. A. Biu ◽  
L. B. Buratai ◽  
A. A. Ahmed ◽  
I. U. Hambali ◽  
S. I. Ngulde ◽  
...  
Keyword(s):  
Body Weight ◽  
Trypanosoma Brucei ◽  
Aqueous Extract ◽  
Carica Papaya ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Albino Rats ◽  
Loss Of Appetite ◽  
Crude Aqueous Extract

The aqueous extract of Carica papaya leaf was evaluated for its phytochemistry, acute toxicity and in vitro antitrypanosomal efficacy in this study. A total of 15 albino rats grouped into 5(A-E) of 3 rats each were intraperitoneally treated with graded doses of 100, 200, 400, 800mg/kg body weight of the aqueous extract and observed for 24 hours for clinical signs and death. The calculated median lethal dose (LD50) was 600mg/kg body weight, with clinical signs of sluggishness, awkward pasture, loss of appetite, starry hair coat and terminal death within 24 hours. Severity of clinical signs varied with increasing doses. The in vitro antitrypanosomal efficacy of the aqueous extract showed 100% inhibition of Trypanosoma brucei at concentrations of 40mg/ml, 20mg/ml, 10mg/ml, 5mg/ml and 2.5mg/ml respectively. In conclusion the aqueous extract of C. papaya leaf has bioactive components that are moderately toxic and has trypanosomal inhibitory activity.

scholarly journals STUDIES ON BIOCHEMICAL EFFECTS OF AQUEOUS EXTRACT OF CARICA PAPAYA LEAF ON ALLOXAN-INDUCED DIABETIC ALBINO RATS

Food Biology ◽  
1970 ◽  
pp. 28-35
Author(s):  
EZEKWE AHAMEFULA ◽  
NWADIKE CONSTANCE ◽  
EBOAGWU IJEOMA ◽  
ODIKA PRINCE, NJOKU SAMUEL
Keyword(s):  
Renal Function ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Pharmacological Property ◽  
Carica Papaya ◽  
Diabetic Control ◽  
Albino Rats ◽  
Control Test ◽  
Biochemical Effects ◽  
Wistar Strain

Studies on biochemical effects of aqueous extract of Carica papaya leaf on alloxan-induced diabetic albino rats were undertaken. One hundred albino rats of Wistar strain were obtained and divided into five groups of twenty rats each and properly treated with the aqueous extract after four out of the five groups were induced with diabetes. The diabetic induced groups were diabetic control, test groups I (treated with 200 mg/kg) and II (treated with 50 mg/kg), and reference (treated with the standard glibenclamide). The diabetic free group was designated as normal control. Results obtained revealed that oral administration of aqueous extract of C. papaya leaf on alloxan-induced diabetic albino rats significantly reversed the damage associated with alloxan-induced diabetes revealing its hypoglycemic, liver and renal function integrity effects. The presence of phytochemicals and phytonutrients found in C. papaya could explain the observed pharmacological property of the studied extract. This study has revealed the biochemical effects of aqueous extract of C. papaya leaf on alloxan-induced diabetic albino rats.

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