The Antidiabetic Effect of Cinnanomum zeylenicum (Girfa) Aqueous Extract on Induced Diabetic Albino Rats

Context. Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes. Objective. To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect. Methods. 5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage. Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation. Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks. Metabolic parameters were measured on sera. A horizontal electrophoresis of plasmatic lipoprotein was conducted. Glycogen, total lipids, and triglycerides were measured in the liver. TBARS were evaluated on adipose tissue, liver, and pancreas. Results. AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver. In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c. Results on the liver indicated a decrease in lipids and a possible glycogenogenesis. Conclusion. AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.

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EFFECT OF AQUEOUS EXTRACT OF CARICA PAPAYA DRY ROOT POWDER ON LACTATION OF ALBINO RATS

Acta Horticulturae ◽

10.17660/actahortic.2005.678.10 ◽

2005 ◽

pp. 85-90 ◽

Cited By ~ 3

Author(s):

G. Tossawanchuntra ◽

S. Aritajat

Keyword(s):

Aqueous Extract ◽

Carica Papaya ◽

Albino Rats

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Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

IMC Journal of Medical Science ◽

10.3329/imcjms.v12i1.35171 ◽

2018 ◽

Vol 12 (1) ◽

pp. 11-14

Author(s):

Sharmin Rahman ◽

Mohammad Rezaul Quader ◽

Md Ismail Khan

Keyword(s):

Body Weight ◽

Peptic Ulcer ◽

Gastric Ulcer ◽

Aqueous Extract ◽

Protective Efficacy ◽

Albino Rats ◽

Ulcer Formation ◽

Aegle Marmelos ◽

Rat Stomach ◽

Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

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A STUDY OF THE EFFECT OF THE PHYTOCHEMICAL CONTENT OF P. AMERICANALEAF ON HEMATOLOGICAL SYSTEM OF ALBINO RATS

International Journal of Advanced Research ◽

10.21474/ijar01/12711 ◽

2021 ◽

Vol 9 (04) ◽

pp. 464-467

Author(s):

Ngozi a ◽

◽

N. Omeke ◽

Haruna M. Ndahi ◽

◽

...

Keyword(s):

Adverse Effect ◽

Experimental Study ◽

Aqueous Extract ◽

Leaf Extract ◽

Control Group ◽

Albino Rats ◽

Phytochemical Content ◽

Other Substances ◽

And Control ◽

Experimental Group

Given the medicinal importance of the avocado plant in alternative medicine,the present study aimed to study the effect of the phytochemical content of P. americana leaf extract on the hematological system of albino rats. Albino rats were obtained andclustered into sixgroups,with five rats per groupsimultaneously were assigned experimental and control. The rats in the experimental group were administered with varying doses of the prepared aqueous extract of P. americanawithin the period of the study. The rats in the control group were administered with other substances such as water and feed for the study period.The hematological system of the experimental animal was assessed after the administration of the extract, and it was observed that the aqueous extract of P. americana leaf recorded no significant adverse effect on the hematology system of the experimental study animal.

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IFLUENCE OF AQUEOUS EXTRACT FROM FEIJOA LEAVES ON THYROID FUNCTION IN RATS WITH EXPERIMENTAL HYPOTHYROIDISM

EUREKA Life Sciences ◽

10.21303/2504-5695.2019.00889 ◽

2019 ◽

Vol 3 ◽

pp. 9-14

Author(s):

Alevtyna Kononenko ◽

Vera Kravchenko

Keyword(s):

Body Weight ◽

Thyroid Function ◽

Aqueous Extract ◽

Rectal Temperature ◽

Albino Rats ◽

Reference Drug ◽

Functional Changes ◽

Thyroid Mass ◽

Serum Thyroid Hormone ◽

Thyroid Hormone Levels

The present work studied the effect of aqueous extract from Feijoa leaves on thyroid function of rats with experimental hypothyroidism. Healthy albino rats weighing between 120 gand 150 gwere used. The animals were randomly allotted into four groups, each containing eight rats respectively. Three of the groups (II, III and IV), induced with hypothyroidism, were treated by 0.05 % solution of thiamazole with drinking water for 30 days. Control (vehicle) rats were given normal saline. After 13 days hypothyroid groups (III and IV) of rats were treated with aqueous extract from Feijoa leaves at a dose 1.0 ml/100 g of body weight and with Iodomarin 200 (reference drug) at a dose 12 µg/kg daily orally for 21 days. Results obtained from the study showed that the introduction of thiamazole leads to functional changes in the thyroid gland in rats, accompanied by decreasing sings of rectal temperature and level of thyroid hormones. It was found, that treatment with AEFL normalizes serum thyroid hormone levels, increases rectal temperature and reduces the thyroid mass. The investigated extract can be attributed to the regulators of the thyroid hypofunction and is promising for further study of its effectiveness as a thyroid-stimulating agent.

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