scholarly journals Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries

2016 ◽  
Author(s):  
Daniela Medeiros Lobo de Andrade ◽  
Leonardo Luis Borges ◽  
Ieda Maria Sapateiro Torres ◽  
Edemilson Cardoso da Conceição ◽  
Matheus Lavorenti Rocha
Keyword(s):  
Isolated Arteries ◽  
Vasodilating Effect

Injection of dye into isolated arteries supplying the brain of the dog

1962 ◽  
Vol 1 (4) ◽  
pp. 303-IN12 ◽  
Author(s):  
Williamina A. Himwich ◽  
Ottilie R. Inman
Keyword(s):  
Isolated Arteries ◽  
The Brain

scholarly journals Endothelium-Dependent Contractions of Isolated Arteries to Thymoquinone Require Biased Activity of Soluble Guanylyl Cyclase with Subsequent Cyclic IMP Production

2016 ◽  
Vol 358 (3) ◽  
pp. 558-568 ◽  
Author(s):  
C. M. Detremmerie ◽  
Z. Chen ◽  
Z. Li ◽  
K. M. Alkharfy ◽  
S. W. S. Leung ◽  
...  
Keyword(s):  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Isolated Arteries

scholarly journals Comparison of the Acute Pulmonary Vasodilating Effect of Beraprost Sodium and Nitric Oxide in Congenital Heart Disease

2005 ◽  
Vol 69 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Kritvikrom Durongpisitkul ◽  
Duangmanee Laoprasitiporn ◽  
Thanarat Layangool ◽  
Rekwan Sittiwankul ◽  
Mannat Panamonta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Beraprost Sodium ◽  
Vasodilating Effect

scholarly journals The Role of Perivascular Adipose Tissue in Early Changes in Arterial Function during High-Fat Diet and Its Combination with High-Fructose Intake in Rats

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1552
Author(s):  
Jozef Torok ◽  
Anna Zemancikova ◽  
Zuzana Valaskova ◽  
Peter Balis
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Control Diet ◽  
Sympathetic Nerves ◽  
High Fat ◽  
Perivascular Adipose Tissue ◽  
Fructose Intake ◽  
High Fructose ◽  
Wistar Kyoto ◽  
Isolated Arteries

The aim of the current study was to evaluate the influence of a high-fat diet and its combination with high-fructose intake on young normotensive rats, with focus on the modulatory effect of perivascular adipose tissue (PVAT) on the reactivity of isolated arteries. Six-week-old Wistar–Kyoto rats were treated for 8 weeks with a control diet (10% fat), a high-fat diet (HFD; 45% fat), or a combination of the HFD with a 10% solution of fructose. Contractile and relaxant responses of isolated rat arteries, with preserved and removed PVAT for selected vasoactive stimuli, were recorded isometrically by a force displacement transducer. The results demonstrated that, in young rats, eight weeks of the HFD might lead to body fat accumulation and early excitation of the cardiovascular sympathetic nervous system, as shown by increased heart rate and enhanced arterial contractile responses induced by endogenous noradrenaline released from perivascular sympathetic nerves. The addition of high-fructose intake deteriorated this state by impairment of arterial relaxation and resulted in mild elevation of systolic blood pressure; however, the increase in arterial neurogenic contractions was not detected. The diet-induced alterations in isolated arteries were observed only in the presence of PVAT, indicating that this structure is important in initiation of early vascular changes during the development of metabolic syndrome.

scholarly journals Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ERα knockout mice: role of aromatase

2007 ◽  
Vol 293 (3) ◽  
pp. R1239-R1246 ◽  
Author(s):  
Dong Sun ◽  
Changdong Yan ◽  
Azita Jacobson ◽  
Houli Jiang ◽  
Mairead A. Carroll ◽  
...  
Keyword(s):  
Gas Chromatography Mass Spectrometry ◽  
Epoxyeicosatrienoic Acids ◽  
Epoxyeicosatrienoic Acid ◽  
Wild Type ◽  
Electrophysiological Technique ◽  
Isolated Arteries ◽  
Oxide Synthase ◽  
Interfering Rna ◽  
Endothelial Nitric Oxide

We studied the roles of estrogen receptors (ER) and aromatase in the mediation of flow-induced dilation (FID) in isolated arteries of male ERα-knockout (ERα-KO) and wild-type (WT) mice. FID was comparable between gracilis arteries of WT and ERα-KO mice. In WT arteries, inhibition of NO and prostaglandins eliminated FID. In ERα-KO arteries, Nω-nitro-l-arginine methyl ester (l-NAME) inhibited FID by ∼26%, whereas indomethacin inhibited dilations by ∼50%. The remaining portion of the dilation was abolished by additional administration of 6-(2-proparglyoxyphenyl)hexanoic acid (PPOH) or iberiotoxin, inhibitors of epoxyeicosatrienoic acid (EET) synthesis and large-conductance potassium channels, respectively. By using an electrophysiological technique, we found that, in the presence of 10 dyne/cm2 shear stress, perfusate passing through donor vessels isolated from gracilis muscle of ERα-KO mice subjected to l-NAME and indomethacin elicited smooth muscle hyperpolarization and a dilator response of endothelium-denuded detector vessels. These responses were prevented by the presence of iberiotoxin in detector or PPOH in donor vessels. Gas chromatography-mass spectrometry (GC-MS) analysis indicated a significant increase in arterial production of EETs in ERα-KO compared with WT mice. Western blot analysis showed a significantly reduced endothelial nitric oxide synthase expression but enhanced expressions of aromatase and ERβ in ERα-KO arteries. Treatment of ERα-KO arteries with specific aromatase short-interfering RNA for 72 h, knocked down the aromatase mRNA and protein associated with elimination of EET-mediation of FID. Thus, FID in male ERα-KO arteries is maintained via an endothelium-derived hyperpolarizing factor/EET-mediated mechanism compensating for reduced NO mediation due, at least in part, to estrogen aromatized from testosterone.

THE INTERACTION OF HYDROGEN SULFIDE WITH NO-SYNTHASE AND NO DONORS TRIGGERS SPECIFIC VASOACTIVE EFFECTS IN ISOLATED ARTERIES OF RATS AND PATIENTS WITH ARTERIAL HYPERTENSION

2018 ◽  
Vol 25 (3) ◽  
pp. 181
Author(s):  
Sona Cacanyiova ◽  
Andrea Berenyiova ◽  
Marian Grman ◽  
Karol Ondrias ◽  
Jan Breza ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Arterial Hypertension ◽  
No Synthase ◽  
No Donors ◽  
Isolated Arteries

Aglycone-rich extracts from citrus by-products induced endothelium-independent relaxation in isolated arteries

2020 ◽  
Vol 23 ◽  
pp. 101481
Author(s):  
Amanda Roggia Ruviaro ◽  
Paula de Paula Menezes Barbosa ◽  
Eduardo Costa Alexandre ◽  
Alberto Fernando Oliveira Justo ◽  
Edson Antunes ◽  
...  
Keyword(s):  
Isolated Arteries ◽  
By Products

scholarly journals Vasorelaxing responses of isolated arteries from spontaneously hypertensive rats to bepridil and methylbepridil

1988 ◽  
Vol 46 ◽  
pp. 94
Author(s):  
Seigo Fujitmoto ◽  
Yasuaki Dohi ◽  
Kyuzo Aoki ◽  
Tomohiro Matsuda
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Isolated Arteries
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